Dynamics of bone graft healing around implants

Background: Critically sized surgical bony defects after enucleation of cystic bony lesions will not spontaneously heal.Purpose: This clinical study aimed to assess the osteoinductive potential of bioactive bone glass in the form of sticky bone in critical-sized surgical bony defects.Patients and methods: the present study is a randomized clinical controlled trial including 24 patients divided into two equal groups. Cystic lesions exceeding 2 x 2 cm were enucleated, and the defect was obliterated with bioactive bone glass particles in group 1 and bioactive glass sticky bone in group 2. Bone density was measured in grayscale units from digital panoramic radiographs immediately, at three and six months postoperatively. Results:The healing went uneventful, except for the exfoliation of graft particles through the incision line in groups 1. In group 1, the percentage of decrease in the bone density during the first three months is higher in group 1 than group 2 that was then increased by nearly the same percentage at the six months interval although statisticaly there is no significant difference between the two groups through out the study period. Conclusion:The bioactive glass prepared as the sticky bone has better intraoperative handling and workability, better soft tissue reaction during the healing period and higher bone density values of the grafted defects than when used solely although it hasn't any radiographic statistical significant results regarding the studied parameters.

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“…This is facilitated by the precipitated layer of calcium and ohosphate over the silicon rich layer. 39 (1906)…”

Section: Discussionmentioning

confidence: 99%

Assessment Of The Sticky Bone Preparation Of BioActive bone Glass in Grafting Critical-Sized Surgical Bony Defects.

El-Hawary

Shawky

2021

Egyptian Dental Journal

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“…Considering that bones are composed of miscellaneous components such as hydroxyapatite (HA) mineral, organic components (type I collagen, lipids, and non-collagenous proteins), and water [56,57], this combination of materials likely allows the biological activity of scaffolds and their bio-architecture to be accomplished [54]. The bioactivity of tissue engineering scaffolds can also be improved by integrating compounds that correlate organs and cells at the cellular organizational level [58] and, therefore, lead to osteoconduction (bone cell ingrowth), osseointegration (steady attachment to the tissue defect), osteoinduction (stimulation of immature cells into osteogenic ones), and vascularization [59]. Due to the versatile roles of natural bone in the body, bone tissue engineering scaffolds should present several different characteristics to effectively function as a bone scaffold [60].…”

Section: Scaffold Properties For Bone Tissue Engineeringmentioning

confidence: 99%

“…The main structural characteristics (such as high porosity, high mechanical properties, and tunable architecture), common compositions (polymers, ceramics, and composites), biological requirements (including nontoxicity, biocompatibility, low immunogenic response, and bioactivity), as well as conventional and advanced manufacturing methods (including freeze-drying, electrospinning, and solvent casting) for bone tissue engineering scaffolds are listed in Figure 3. and, therefore, lead to osteoconduction (bone cell ingrowth), osseointegration (steady attachment to the tissue defect), osteoinduction (stimulation of immature cells into osteogenic ones), and vascularization [59]. Due to the versatile roles of natural bone in the body, bone tissue engineering scaffolds should present several different characteristics to effectively function as a bone scaffold [60].…”

Section: Scaffold Properties For Bone Tissue Engineeringmentioning

confidence: 99%

Advances in Growth Factor Delivery for Bone Tissue Engineering

Oliveira

Nie

Podstawczyk

et al. 2021

IJMS

136

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Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues. Although recent studies on developing novel growth factor delivery systems for bone repair have attracted great attention, taking into account the complexity of the extracellular matrix, scaffolding and growth factors should not be explored independently. Consequently, systems that combine both concepts have great potential to promote the effectiveness of bone regeneration methods. In this review, recent developments in bone regeneration that simultaneously consider scaffolding and growth factors are covered in detail. The main emphasis in this overview is on delivery strategies that employ polymer-based scaffolds for spatiotemporal-controlled delivery of both single and multiple growth factors in bone-regeneration approaches. From clinical applications to creating alternative structural materials, bone tissue engineering has been advancing constantly, and it is relevant to regularly update related topics.

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“…5,6 Osteoblasts fill resorption pits created by the osteoclasts with osteoid, which eventually becomes mineralized and subsequently remodeled. 5,10 Complete resorption and replacement of the autograft with new bone typically occurs within 6–12 months but may take years if the graft is derived from dense cortical bone. 6,11 A subset of autograft tissue includes bone marrow aspirate (BMA).…”

Section: Introductionmentioning

confidence: 99%

Effect of increasing mineralization on pre-osteoblast response to native collagen fibril scaffolds for bone tissue repair and regeneration

Grue

Veres

2022

Journal of Applied Biomaterials & Functional Materials

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With limited availability of auto- and allografts, there is increasing demand for alternative bone repair and regeneration materials. Inspired by a mimetic approach, the utility of producing engineered native protein scaffolds is being increasingly realized, demonstrating the need for continued research in this field. In previous work, we detailed a process for producing mineralized collagen scaffolds using tendon to create collagen templates of highly aligned, natively crosslinked collagen fibrils. The process produced mineral phase closely matching that of native bone, and integration of mineral with the collagen template was demonstrated to be easily controlled, allowing scaffolds to be mechanically tuned. In the current study, we have extended this work to investigate how variation in the mineralization level of these scaffolds affects the osteogenic response of pre-osteoblastic cells. Scaffolds were produced under three treatment groups, where collagen templates underwent 0, 5, or 20 mineralization cycles. Scaffolds in each treatment group were cultured with MC3T3-E1 cells for 1, 7, or 14 days. Morphologic assessment under SEM indicated decreased attachment to the mineralized scaffolds, supported by DNA results showing a significant drop between culture days 1 and 7 for mineralized scaffolds only. For adherent cells, increasing scaffold mineralization also delayed cell spreading. While mineralization presented a barrier to cell coverage of scaffolds, it increased osteogenic activity, with cells on the mineralized scaffolds showing significantly greater alkaline phosphatase activity and osteocalcin production. Understanding how increasing collagen mineralization effects pre-osteoblast function may enable design of more advanced mineralized collagen scaffolds for bone repair and regeneration.

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Dynamics of bone graft healing around implants

Cited by 17 publications

References 2 publications

Assessment Of The Sticky Bone Preparation Of BioActive bone Glass in Grafting Critical-Sized Surgical Bony Defects.

Assessment Of The Sticky Bone Preparation Of BioActive bone Glass in Grafting Critical-Sized Surgical Bony Defects.

Advances in Growth Factor Delivery for Bone Tissue Engineering

Effect of increasing mineralization on pre-osteoblast response to native collagen fibril scaffolds for bone tissue repair and regeneration

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