“…All studies included patients with apical periodontitis which were documented via CBCT. They reported the measured volume of periapical lesions: two studies combined the volumetric measurements of periapical lesions, as well as those of the maxillary sinus mucosa [ 3 , 20 ], whereas eleven studies used CBCT to measure the apical lesion volume solely to distinguish healing outcomes and/or compare it with other dental imaging techniques [ 10 , 11 , 12 , 15 , 16 , 17 , 21 , 53 , 54 , 55 , 56 ], two studies used the measured volume to evaluate the accuracy of periapical indices [ 13 , 18 ], and one study compared CBCTPAVI index to the sphericity of the lesions [ 19 ]. The key point investigated was the volumetric determination of apical lesions and their alteration in size and dimension after successful endodontic treatment in different follow-up time spans, alongside the comparison of accuracy between 3D and 2D radiographic measurements in dentistry.…”