Dynamics of bone tissue formation in tooth extraction sites

Cardaropoli, Giuseppe; Araújo, Maurício G.; Lindhe, Jan

doi:10.1034/j.1600-051x.2003.00366.x

Cited by 666 publications

(761 citation statements)

References 11 publications

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“…The percentages of the points hitting vascularised tissue, provisional matrix (e.g. connective tissue), osteoid and mineralised bone, as well as residual tissue were calculated as previously described [12].…”

Section: Morphometric Analysismentioning

confidence: 99%

Healing of osteotomy sites applying either piezosurgery or two conventional saw blades: a pilot study in rabbits

Stübinger

Liu

et al. 2013

International Orthopaedics (SICOT)

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Purpose The purpose of this study was to compare bone healing of experimental osteotomies applying either piezosurgery or two different oscillating saw blades in a rabbit model. Methods The 16 rabbits were randomly assigned into four groups to comply with observation periods of one, two, three and five weeks. In all animals, four osteotomy lines were performed on the left and right nasal bone using a conventional saw blade, a novel saw blade and piezosurgery. Results All three osteotomy techniques revealed an advanced gap healing starting after one week. The most pronounced new bone formation took place between two and three weeks, whereby piezoelectric surgery revealed a tendency to faster bone formation and remodelling. Yet, there were no significant differences between the three modalities. Conclusions The use of a novel as well as the piezoelectric bone-cutting instrument revealed advanced bone healing with a favourable surgical performance compared to a traditional saw.

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Section: Morphometric Analysismentioning

confidence: 99%

Healing of osteotomy sites applying either piezosurgery or two conventional saw blades: a pilot study in rabbits

Stübinger

Liu

et al. 2013

International Orthopaedics (SICOT)

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“…[1][2][3][4][5] The temporary scaffold of the fibrin-rich matrix staunches bleeding and provides support for immigrating cells that form the granulation tissue. 6,7 Among these cells are mesenchymal progenitors that can be attracted by signaling molecules released from activated platelets.…”

mentioning

confidence: 99%

“…[11][12][13] Endothelial cells and mesenchymal cells are both key elements of the granulation tissue; however, the influence of platelets on mesenchymal progenitors has not been examined so far. 2,3 Mesenchymal progenitors are present in a broad spectrum of tissues, such as bone marrow, periosteum, synovial membrane, and the vasculature where they are supposed to contribute to bone remodeling and regeneration. [14][15][16][17] Bone marrow stromal cells (BMSC) are commonly used to elucidate the response of mesenchymal progenitors to signaling molecules.…”

mentioning

confidence: 99%

Activated platelets increase fibrinolysis of mesenchymal progenitor cells

Agis

Kandler

Fischer

et al. 2008

Journal Orthopaedic Research

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Bone regeneration is initiated by the formation of a blood clot. Activated platelets within this fibrin-rich matrix release signaling molecules that can attract mesenchymal progenitor cells. To gain insight into the cellular mechanism by which activated platelets can support the immigration of mesenchymal progenitors, we have tested the hypothesis that platelet-released signaling molecules increase the capacity of bone marrow stromal cells (BMSC) to activate plasminogen. We report herein that platelet-released supernatants (PRS) elevate total urokinase-type plasminogen activator (uPA) and total plasminogen activator inhibitor-1 (PAI-1) levels in BMSC, as assessed by immunoassay. Quantitative polymerase chain reaction showed an upregulation of uPA, uPA receptor, and PAI-1. Zymography and kinetic analysis based on casein hydrolysis revealed enhanced activity of cell-associated uPA upon exposure of BMSC to PRS. Inhibiting c-Jun Nterminal kinase (JNK) and phosphatidylinositol 3-kinase (PI3K) signaling reduced uPA production and decreased plasminogen activation. Corresponding Western blot analysis showed increased phosphorylation of JNK and AKT in BMSC treated with PRS. These results suggest that activated platelets can enhance the plasminogen activation capacity of mesenchymal progenitors through the stimulation of uPA production, requiring JNK and PI3K/AKT signaling. By this mechanism platelets may contribute to the organization of the blood clot during bone regeneration. ß

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“…After tooth extraction, changes in the alveolar bone and the healing process result in the formation of trabecular and medullary structures and significant bone loss is observed in the socket 1 . The goal of implant rehabilitation therapy is to preserve soft and hard supporting tissues, preventing continuous bone loss.…”

Section: Introductionmentioning

confidence: 99%

In-vivo bone response to titanium screw implants anodized in sodium sulfate

Pinheiro

Mourão

Diniz³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the early bone response to a nanotextured dental implant treated with sodium sulfate (Na 2 SO 4 ), using a rabbit model. METHODS:Twelve animals were randomly divided into group 1 (Control) -machined implants and group 2 (Test) -nanotextured implants. Extra-oral incision was performed to provide access to intended surgical site where the dental implant was inserted immediately after the extraction of the mandibular first premolar. Implant surface characterization was performed by scanning electron microscopy attached to energy dispersive spectroscopy and interferometry. Three weeks after surgery, the animals were induced to death and undecalcified sections of the samples were prepared for histological and histomorphometrical analysis. RESULTS:Surface characterization of the implant demonstrated enhanced surface area of anodized group compared to Control group with 19.2% ± 6.2 versus 1.6 ± 0.7, respectively. Histological evaluation demonstrated new bone formation starting from the buccal and lingual cortical walls on both groups. After three weeks, significant higher bone contact of 27% (p<0.05) was observed to nanotextured compared to machined implants (Control group). CONCLUSION:The anodization with sodium sulfate nanostructures to the implant surface that resulted in faster osseointegration.

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Dynamics of bone tissue formation in tooth extraction sites

Cited by 666 publications

References 11 publications

Healing of osteotomy sites applying either piezosurgery or two conventional saw blades: a pilot study in rabbits

Healing of osteotomy sites applying either piezosurgery or two conventional saw blades: a pilot study in rabbits

Activated platelets increase fibrinolysis of mesenchymal progenitor cells

In-vivo bone response to titanium screw implants anodized in sodium sulfate

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