Dynamics of calcitonin gene-related peptide-like cells changes in the lungs of two-kidney, one-clip rats

Kasacka, Irena; Arciszewska, Ewa

doi:10.4081/ejh.2012.e10

Cited by 6 publications

(9 citation statements)

References 46 publications

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“…6 Besides the abovementioned studies, no information has been found on the subject of dynamics of changes in CART-IR cells in the urinary tract of hypertensive animals in relation to the duration of the illness. The connection between the duration of hypertension and the number of DNES cells has been documented only in studies of Kasacka and Arciszewska 3 who analyzed the dynamics of changes in the number of NE cells under the influence of 3-, 14-, 28-, 42-, and 91-day hypertension. The aim of their studies was to examine the distribution, morphology and dynamics of changes of calcitonin gene related peptide-containing cells in the lungs of rats in the two-kidney, one-clip (2K1C) renovascular hypertension model.…”

Section: Discussionmentioning

confidence: 99%

“…Analyzing the results, the greatest intensity of NE cells in the lungs of rats was noticed 14 days after the surgical procedure. 3 …”

Section: Discussionmentioning

confidence: 99%

“…However, they can simultaneously play roles as mediators in several circulatory disorders, including renovascular hypertension. 3 Among the active substances secreted by DNES cells, there is the cocaine and amphetamine regulated transcript (CART), produced and secreted in the hypothalamus and in other tissues in many vertebrates. 4-11 Despite considerable progress made in the area of structure and physiological description of this factor, its role in the pathogenesis of human hypertension is controversial.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

Janiuk¹,

Kasacka

2015

Eur J Histochem

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Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART) is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB) of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip) to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells.As this study provides novel findings, the question appears about the type of connection between hypertension and the functioning and activity of CART in the urinary tract (UT). The study gives rise to the assumption that high blood pressure can be a factor that intensifies CART secretion. In conclusion, the endocrine system of the urinary tract is modified by renovascular hypertension. This may affect the production of hormones and biologically active substances and contribute to the development of possible hypertension complications. In order to fully comprehend the role of the CART peptide in blood pressure regulation, further analyses are necessary.

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Section: Discussionmentioning

confidence: 99%

“…Analyzing the results, the greatest intensity of NE cells in the lungs of rats was noticed 14 days after the surgical procedure. 3 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

Janiuk¹,

Kasacka

2015

Eur J Histochem

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“…hypertension) cause disorders of enteroendocrine cell function, reflected in changes in the number, morphology, location, and activity of these cells in the gastrointestinal tract. This illustrates the important role played by these cells in maintaining whole body homeostasis [45,46,47].…”

Section: Systemic and Local Disor-ders And Neuroendocrine Cells Of Thmentioning

confidence: 91%

Gastrointestinal neuroendocrine cells in various types of hypertension – a review

Niezgoda

2017

Prog Health Sci

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Recent years have witnessed a progressive increase in the number of people suffering from hypertension, which is one of the most serious health problems in the world. Hypertension results in changes leading to function disorders, not only of the organs and tissues, but also changes leading to the activation of many defense mechanisms in the cells in order to prevent damage. One of them is the expression of neuroendocrine (NE) hormones and biologically active substances, which has been the focus of extensive research for a number of years. Active involvement of NE cells and the biological and therapeutic properties of various substances synthesized by them have been confirmed in clinical trials and in various experimental models. Results obtained in many research studies indicate intense activity of enteroendocrine cells in the gastrointestinal tract in various pathological conditions, including hypertension. In the present review, we discuss the morphological and functional changes of gastrointestinal neuroendocrine cells under conditions of different types of hypertension.

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“…The distribution of CGRP-IR endocrine cells was previously investigated in stomachs of rats (Kasacka 2009) and porcupines (Yaman et al 2007). However, there are no reports in the literature that describe CGRP-IR cells in the intestines of rodents with immunohistochemistry.…”

Section: Duodenummentioning

confidence: 99%

Distribution of neuroendocrine cells in the small and large intestines of the mole-rats (Spalax leucodon)

Bayrakdar

Yaman

Ilgün

2015

Animal Cells and Systems

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In this research, we aimed to determine the regional distribution and relative frequency of immunoreactive (IR) endocrine cells of ghrelin, glucagon, somatostatin-14 (SOM-14), neuropeptide Y (NPY), calcitonin-gene-related peptide (CGRP), insulin and galanin in small and large intestines of mole-rats (Spalax leucodon) by using immunohistochemical staining methods. For this purpose, small and large intestine regions of six adult mole-rats were used as material. In the small and large intestines of mole-rats (S. leucodon), ghrelin, glucagon, SOM-14, NPY and CGRP were identified at various frequencies, but insulin and galanin were not detected in this study. Ghrelin-IR cells were only observed in the small intestine. In addition, the existence of positive staining in the cells was decreased while passing from duodenum to ileum. Glucagon-IR cells were mainly detected in the small intestine regions and colon. SOM-14-IR cells were detected throughout the small intestines with a lesser frequency. NPY-IR cells were also detected in the small and large intestines at various frequencies but not in cecum and rectum. CGRP-IR cells were scarce in duodenum and jejunum, but their numbers increased from ileum to colon. In conclusion, the present study revealed the existence and distributions of neuropeptide-secreting endocrine cells in small and large intestines of mole-rats (S. leucodon).

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Dynamics of calcitonin gene-related peptide-like cells changes in the lungs of two-kidney, one-clip rats

Cited by 6 publications

References 46 publications

Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

Gastrointestinal neuroendocrine cells in various types of hypertension – a review

Distribution of neuroendocrine cells in the small and large intestines of the mole-rats (Spalax leucodon)

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