Dynamics of changes in lipid metabolism indices in organs and tissues of experimental animals under adrenaline stress

Shkurashivska, S. V.; Ersteniuk, H. M.

doi:10.11603/mcch.2410-681x.2015.v17.i4.5681

Cited by 2 publications

(3 citation statements)

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“…On the other hand, the utilization of excessive amounts of adrenaline leads to the formation of adrenochrome (a product of the oxidation of adrenaline by free radicals) and free radicals (semiquinone, etc.) with the further intensification of oxidative damage to molecules (Gupta et al, 2014;Shkurashivska & Erstenyuk, 2015;Rabasa & Dickson, 2016). Our experiments have shown that free radical processes on the one hand, and antioxidant protective mechanisms in the body of animals on the other, under normal conditions and, especially under stress, have tissue specificity.…”

Section: Discussionmentioning

confidence: 63%

“…On the other hand, the role of stress as one of the causes of atherosclerosis, ulcerous lesions of the mucous membrane of the stomach and duodenum, heart and liver function impairment, immunodeficiency and cancer diseases is discussed in numerous studies (Gupta et al, 2012;Cai & Yan, 2013;Gupta et al, 2014;Rabasa & Dickson, 2016). In this regard, the problems of chemical regulation of stress and the search for biologically active substances which have antioxidant activity (AOA) will always be relevant and are the subject of ongoing research by scientists around the world (Khavrona, 2015;Shkurashivska & Erstenyuk, 2015). Despite the large amount of work on the subject, there is a need for additional experimental data to expand our knowledge about the mechanisms of action of antioxidants, especially products of natural origin.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic processes in the organism of animals under the action of plant extract

Buchko

Havryliak

Yaremkevych

et al. 2019

Regul. Mech. Biosyst.

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The possibility of increasing metabolism and resistance in an organism of animals under the influence of biologically active substances of natural origin is considered in the paper. In the current study, we investigated the effect of 40% ethanolic extract of common nettle (Urtica dioica L.) on hematologic indexes (hemoglobin concentration, erythrocytes and leukocytes content), protein metabolism (total protein, aspartate aminotransferase (AST), alanine aminotransferase activities (ALT)), glutathione metabolism (peroxidase (GP), glutathione reductase (GR) and reduced glutathione content (GSH)), antioxidant defense systems (superoxide dismutase (SOD), catalase (CAT)), and indicators of free radical processes (lipid hydroperoxidation products (LHP), TBA-active products and carbonyl groups of protein (CP)) in the blood and tissues of normal and adrenalin-stressed rats. White Wistar rats (male) with body weight 180–200 g were used in the experiments. The animals were divided into 4 groups (control and 3 experimental), each containing 7 animals. The animals of experimental groups D2 and D3 received 40% ethanolic extract of common nettle in a dose of 5 mL/kg of body weight during 4 weeks. After 29 days of the experiment, the animals of D1 and D3 groups were intramuscularly administered 0.1% solution of adrenaline hydrochloride at a dose of 1 mg/kg of body weight. One day after the administration of adrenaline, the animals were decapitated under ether anesthesia. The objects of the study were blood and homogenates of liver, heart, and kidneys of the rats. Our results have shown that adrenaline stress causes a decrease in the concentration of hemoglobin, LHP, SOD activity and increase in activities of AST, GP, GR, and GSH content in the blood of rats. Stress induced by adrenaline was accompanied by decrease in CP content, activities of SOD, CAT, and increase in the glutathione chain of antioxidant defense system in the liver of the animals while in the heart and kidneys, there was an increase in oxidative stress parameters and decrease in antioxidant enzyme activities (SOD, CAT, GP, GR). The administration of ethanolic extract of nettle caused an increase within the physiological range in the erythrocytes and leucocytes content, hemoglobin concentration, and normalization of protein metabolism (decrease in the activity of AST and increase in protein concentration) in the blood of the stressed rats. The activation of the antioxidant defense system (increase in activities of SOD, GP, CAT, GR) and inhibition of free radical processes (decrease in concentration of LHP, TBA-active products and CP) was observed in the tissues of animals of D2 and D3 groups. Our results suggested that using a complex of biologically active substances of the common nettle ethanolic extract prevents metabolic disorders and stresses of different etiology through the activation of the antioxidant defense system, the normalization of protein metabolism and stimulation of hematopoiesis both in normal and stressed rats.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Metabolic processes in the organism of animals under the action of plant extract

Buchko

Havryliak

Yaremkevych

et al. 2019

Regul. Mech. Biosyst.

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“…One of the identified effects of chronic social stress is a significant change in the ratio of serum lipoproteins and blood lipid spectrum, choles-terol synthesis and receptor-mediated transport, fatty acid synthesis and oxidation and cholesterol and triglyceride content in liver cells and other lipid disorders (Chuang et al, 2010;Scott et al, 2012;Shkurashivska & Ersteniuk, 2015). The key reactions of cholesterol metabolism take place in the liver.…”

Section: Introductionmentioning

confidence: 99%

The effect of Corvitin on the content of bile acids in the liver of rats under conditions of chronic social stress

Liashevych

Lupaina

Davydovska

et al. 2021

Regul. Mech. Biosyst.

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The article looks at recent research dealing with changes in the bile acid composition of the bile of outbred male rats under chronic social stress (social defeat in daily male confrontations, 14 days) when administered Corvitin (1 mg/kg, intragastrically, 7 days). Chronic social stress was created by daily agonistic interactions between animals. The main fractions of conjugated bile acids – taurocholic, taurohenodeoxycholic and taurodeoxycholic, glycocholic, glycochenodeoxycholic and glycodeoxycholic and free ones – cholic, chenodeoxycholic and deoxycholic were determined by the method of thin layer chromatography of bile. The conjugation index (ratio of the sum of conjugated cholates to the sum of free ones) and hydroxylation (ratio of the sum of trihydroxycholanic bile acids to the sum of dihydroxycholanic ones) of bile acids were calculated. The research showed that in the conditions of experimental social stress, Corvitin enhances the conjugation of bile acids with taurine and glycine, i.e. stimulates detoxification processes in hepatocytes. In the conditions of chronic social stress in male rats, the processes that had provided the flow of glycoconjugates of bile acids from hepatocytes to the bile ducts were further suppressed. The concentrations of glycocholic acid and glycochenodeoxycholic and glycodeoxycholic acids in the bile of male intruders were lower than the control values. But, as seen in the experiment, the use of Corvitin normalized these indicators. The experiment showed that in the conditions of chronic social stress, the content of cholic acid in the bile of intruder rats decreased, and when correcting the pathological condition using Corvitin, it reached the control values. The use of Corvitin simultaneously with the simulation of experimental social stress normalized the biliary secretory function of the liver, indicating the high potential of using Corvitin as a corrective factor in chronic social stress. Correction of stress-induced pathologies of liver bile-secretory function by Corvitin requires further thorough experimental studies.

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Dynamics of changes in lipid metabolism indices in organs and tissues of experimental animals under adrenaline stress

Cited by 2 publications

References 1 publication

Metabolic processes in the organism of animals under the action of plant extract

Metabolic processes in the organism of animals under the action of plant extract

The effect of Corvitin on the content of bile acids in the liver of rats under conditions of chronic social stress

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