Dynamics of chromosomal aberrations level in residents of an industrial city in conditions of changing atmosphere pollution

Минина, В. И.; Дружинин, В. Г.; Головина, Т.А.; Tolochko, T. A.; Meyer, A. V.; Volkov, Alexey N.; Баканова, М. Л.; Savchenko, Yana Aleksandrovna; Ryzhkova, Anastasia V.; Titov, R. A.; Larin, Sergey Anatolyevich; Kulemin, Yuriy Yevgenyevich

doi:10.17816/ecogen12360-70

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Numerous studies of the frequency of chromosomal aberrations in blood lymphocytes of the population of territories with developed industry demonstrated an increase in genotoxic events in residents exposed to anthropogenic press [1,[7][8][9], showed the prospects of using the test for chromosomal aberrations in the population risk assessment of oncological pathologies [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Database of Frequencies of Chromosomal Aberrations in the Blood of Residents of the Industrial Region

Chshieva¹,

Chshiev²

2019

Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

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Cytogenetic biomarkers are an important characteristic of mutagenesis and, as practice has shown, carcinogenesis, they are often used in human populations biomonitoring. The uniqueness of genetic tests in the possibility of assessment before morphological, physiological and population changes, the relevance of prevention and early diagnosis of disease, reducing the risk of genotoxic effects, the likelihood of long-term medical and biological effects. The database contains the results of cytogenetic examination of more than 800 respondents from North Ossetia.In 10 years of research analyzed more than 100,000 metaphases. The frequency of aberrant metaphases in the basic control group was found to be 0.02494, statistically significantly different from the results obtained in the group with exposure-0.03238, p<0.001. For the entire database for the study period (from 2002 to 2011) in the study region (RSO-A) the frequency of cells with chromosomal aberrations is 0.02815. There were no statistically significant differences in cytogenetic parameters between the sexes, the study of the effect of smoking on the frequency of chromosomal aberrations demonstrated ambiguous effects. The dependence of the frequencies and types of chromosomal aberrations on age is shown. Throughout the database, the frequency of aberrant metaphases in adults and children-3,222 and 1,815, respectively, p<0,001.

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Section: Introductionmentioning

confidence: 99%

Analysis of the Database of Frequencies of Chromosomal Aberrations in the Blood of Residents of the Industrial Region

Chshieva¹,

Chshiev²

2019

Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

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Complex Approach to Evaluating Genotoxicity from Occupational Factors in Coal Mining Industry

et al. 2020

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Genomic Features of Detoxification System of Newly-Arrived and Indigenous Population of the Amur Region

Suprun¹,

Suprun²,

Кудряшова³

et al. 2018

Bulletin Physiology and Pathology of Respiration

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Taking into account new approaches in medicine of the 21st century (personalization, prediction, prevention and participation), biogeochemical features of the Amur region, and inhomogeneity of ethnic makeup, the purpose of the work was to determine the occurrence frequency of genes of detoxification system predisposition (glutathione S-transferases – GST) among the population of the Amur region. Ethnic and environmental components were taken into account. Risk groups of pregnant women were formed. Substantiation of a personalized approach to a set of preventive measures for the development of pathological conditions was made. Evaluation of gene polymorphism of phase II xenobiotic biotransformation (GSTT1, GSTM1) was carried out by polymerase chain reaction using diagnostic kits produced by the Center of Molecular Genetics (Moscow). 255 pregnant women of newly-arrived and indigenous population from urban areas (Khabarovsk city) and rural areas of the Amur region (Nanai district) were examined. All examined women were divided into 3 groups: 1 group – urban newcomers, representatives of the (European) Slavic race (n=128); 2 group – rural newcomers, representatives of the (European) Slavic race (n=67); 3 group – rural indigenous of the Mongoloid race (the Nanais), who represent small-numbered peoples of the North, Siberia and the Far East of the Russian Federation from places of traditional residence (n=60). A comparative analysis of the obtained results was carried out in the observed groups. The results were also compared with the data provided by the authors of other regions of the Russian Federation similar in climatic and geographical characteristics (Eastern, Western and Northern Siberia). An ethnic feature of the detoxification system (GSTT1 and GSTM1) of the Amur region indigenous women (nanaian women) was revealed, which is a high frequency of combined deletion polymorphism. The study not only contributes to the scientific and theoretical knowledge, but it is also the basis for the development of additional methods of prevention and correction of disorders associated with exo- and endogenous influence on women in preconception and gestational periods.

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Dynamics of chromosomal aberrations level in residents of an industrial city in conditions of changing atmosphere pollution

Cited by 4 publications

References 6 publications

Analysis of the Database of Frequencies of Chromosomal Aberrations in the Blood of Residents of the Industrial Region

Analysis of the Database of Frequencies of Chromosomal Aberrations in the Blood of Residents of the Industrial Region

Complex Approach to Evaluating Genotoxicity from Occupational Factors in Coal Mining Industry

Genomic Features of Detoxification System of Newly-Arrived and Indigenous Population of the Amur Region

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