Dynamics of circadian fluctuations in serum concentration of cortisol and TNF-alpha soluble receptors in gastrointestinal cancer patients.

Zubelewicz-Szkodzińska, Barbara; Muc-Wierzgoń, Małgorzata; Wierzgoń, Janusz; Brodziak, Andrzej

doi:10.3892/or.8.1.207

Cited by 6 publications

(5 citation statements)

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“…Cancer itself, its treatments, and its complications can activate cytokine signaling pathways including those of nuclear factor kappa B (NF κ B) and p38 mitogen-activated protein kinase (MAPK) [ 23 ]. Circadian rhythms of cytokine release have been demonstrated in people with advanced neoplasms [ 24 ]. Third, D-dimer and CRP levels were elevated in 89% and 95%, respectively, of our patients, as occurs in cases of VTE and PE [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Venous Obstruction in Cancer Patients

Liaw

Chang

Yang

et al. 2015

Journal of Oncology

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Background. We study the clinical significance and management of pulmonary venous obstruction in cancer patients. Methods. We conducted a prospective cohort study to characterize the syndrome that we term “pulmonary vein obstruction syndrome” (PVOS) between January 2005 and March 2014. The criteria for inclusion were (1) episodes of shortness of breath; (2) chest X-ray showing abnormal pulmonary hilum shadow with or without presence of pulmonary edema and/or pleural effusion; (3) CT scan demonstrating pulmonary vein thrombosis/tumor with or without tumor around the vein. Results. Two hundred and twenty-two patients developed PVOS. Shortness of breath was the main symptom, which was aggravated by chemotherapy in 28 (13%), and medical/surgical procedures in 21 (9%) and showed diurnal change in intensity in 32 (14%). Chest X-rays all revealed abnormal pulmonary hilum shadows and presence of pulmonary edema in 194 (87%) and pleural effusion in 192 (86%). CT scans all showed pulmonary vein thrombosis/tumor (100%) and surrounding the pulmonary veins by tumor lesions in 140 patients (63%). PVOS was treated with low molecular weight heparin in combination with dexamethasone, and 66% of patients got clinical/image improvement. Conclusion. Physicians should be alert to PVOS when shortness of breath occurs and chest X-ray reveals abnormal pulmonary hilum shadows.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Venous Obstruction in Cancer Patients

Liaw

Chang

Yang

et al. 2015

Journal of Oncology

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“…23 The levels of cortisol and TNF-a displayed statistically significant circadian fluctuations in gastrointestinal cancer. 23,24 The presence of complex self-regulation mechanisms among the neuroendocrine system, the hypothalamic-pituitaryadrenal axis, and the cytokine network in advanced cancer patients also has been suggested. 25e27 The elevation of serum cytokines correlated with cortisol rhythm has been demonstrated in patients with metastatic colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Using Vital Sign Flow Sheets Can Help to Identify Neoplastic Fever and Other Possible Causes in Oncology Patients: A Retrospective Observational Study

Liaw

Huang

Chen

et al. 2010

Journal of Pain and Symptom Management

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“…75 Whether cancer cells of a specific tumor are intrinsically rhythmic or not, they are exposed to the usual daily rhythms of numerous hormones including melatonin at night and corticosteroids that reach a peak during the morning 137 and persist in cancer patients. 138,139 Daily serum corticosteroid rhythms likely induce the core clock gene Per1. 140 Dexamethasone is in fact often used to synchronize circadian clocks in tumor-derived and non-cancer cell cultures.…”

Section: Opportunities For Timed Optimal Curcuminoid Deliverymentioning

confidence: 99%

Anticancer Properties of Curcumin and Interactions With the Circadian Timing System

Beligala

Birkholz

et al. 2019

Integr Cancer Ther

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The phytochemical curcumin is a major component of turmeric. It has recognized activity against cancer cells and affects several intracellular signaling pathways. Many molecules targeted by curcumin also regulate the circadian timing system that has effects on carcinogenesis, tumor growth, and metastasis. Although the circadian clock within cells may be suppressed in tumors, cancer cells are subjected to daily hormonal and neural activity that should be considered when timing optimal curcumin treatments. Rapid curcumin degradation in blood and tissues provides a challenge to maintaining sustained levels suitable for inducing cancer cell death, increasing the need to identify when during the circadian cycle rhythmically expressed molecular targets are present. Curcumin is well tolerated by individuals ingesting it for possible cancer prevention or in combination with conventional cancer therapies, and it shows low toxicity toward noncancerous cells at low dosages. In contrast, curcumin is particularly effective against cancer stem cells, which are treatment-resistant, aggressive, and tumor-initiating. Although curcumin has poor bioavailability, more stable curcumin analogs retain the anti-inflammatory, antioxidant, antimitotic, and pro-apoptotic benefits of curcumin. Anticancer properties are also present in congeners of curcumin in turmeric and after curcumin reduction by intestinal microbes. Various commercial curcuminoid products are highly popular dietary supplements, but caution is warranted. Although antioxidant properties of curcumin may prevent carcinogenesis, studies suggest curcumin interferes with certain chemotherapeutic agents. This review delves into the complex network of curcuminoid effects to identify potential anticancer strategies that may work in concert with daily physiological cycles controlled by the circadian timing system.

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Dynamics of circadian fluctuations in serum concentration of cortisol and TNF-alpha soluble receptors in gastrointestinal cancer patients.

Cited by 6 publications

References 0 publications

Pulmonary Venous Obstruction in Cancer Patients

Pulmonary Venous Obstruction in Cancer Patients

Using Vital Sign Flow Sheets Can Help to Identify Neoplastic Fever and Other Possible Causes in Oncology Patients: A Retrospective Observational Study

Anticancer Properties of Curcumin and Interactions With the Circadian Timing System

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