Dynamics of colonization in patients with health care-associated infections at step-down care units from a tertiary care hospital in Mexico

Cruz-López, Flora; Villarreal-Treviño, Licet; Morfín‐Otero, Rayo; Martínez-Meléndez, Adrián; Camacho-Ortíz, Adrián; Rodríguez-Noriega, Eduardo; Garza‐González, Elvira

doi:10.1016/j.ajic.2020.04.016

Cited by 9 publications

(22 citation statements)

References 26 publications

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“…[ 8 ] In our study, diverse associations between bacterial species and environmental samples were found. In addition, all monitored patients developed at least one HAI,[ 6 ] and the presence of some causative agents on the sampled surfaces (bedrail and table) was demonstrated in patients who subsequently developed an infection.…”

Section: Discussionmentioning

confidence: 99%

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Microbial diversity and colonization patterns of two step-down care units from a tertiary care hospital

Garza‐González

Cruz-López

Villarreal-Treviño

et al. 2021

Journal of Research in Medical Sciences

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Nosocomial surfaces are potential pathogen reservoirs. Our aim was to describe the microbial diversity and analyze microbial patterns of healthcare-associated pathogens in two step-down-care-units at a tertiary care hospital. We monitored infected patients over 45 days to describe microbial diversity and colonization patterns. A total of 2762 isolates were recovered from the sampled sites, coagulase-negative staphylococci represented 44.64% (1233/2762) of the isolates. The most frequently recovered ESKAPE species ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter cloacae ) were A. baumannii (7.53%; 208/2762 isolates) and E. faecium / Enterococcus faecalis (5.18%; 143/2762). We recovered a high diversity of species, including potential pathogens. A. baumannii was detected more frequently on diverse surfaces and persisted in patients’ nostrils during the hospital stay.

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Section: Discussionmentioning

confidence: 99%

“…Causative agents were present on environmental surfaces and medical devices before and after HAI onset. [ 6 ] Here, we describe an additional analysis concerning all isolates; our aim was to analyze the microbial diversity on surfaces, nurses, visitors, and infected patients over time in two SDCU.…”

Section: Introductionmentioning

confidence: 99%

Microbial diversity and colonization patterns of two step-down care units from a tertiary care hospital

Garza‐González

Cruz-López

Villarreal-Treviño

et al. 2021

Journal of Research in Medical Sciences

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“…Besides S. aureus , other pathogens, such as Pseudomonas aeruginosa , K. pneumoniae , A. baumannii , and S. epidermidis , are a main cause of nosocomial infection ( Magill et al., 2014 ; Magill et al., 2018 ; Cruz-Lopez et al., 2020 ). We therefore assessed antimicrobial activity of MoWa against these nosocomial pathogens.…”

Section: Resultsmentioning

confidence: 99%

“…Outbreaks of MRSA infection have been also reported in neonatal intensive care units ( Kim et al., 2019 ). Along the same lines, other Gram-positive and Gram-negative bacteria that cause a high burden of hospital acquired infections include Klebsiella pneumoniae , Staphylococcus epidermidis , and Acinetobacter baumannii ( Magill et al., 2014 ; Magill et al., 2018 ; Cruz-Lopez et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…It is widely recognized that the environment is a vector that facilitates the transmission of nosocomial pathogens. The environment become contaminated with bacteria shed by hospital staff, patients, and their relatives, and persist in the environment for months ( Kristinsdottir et al., 2019 ; Cruz-Lopez et al., 2020 ). Hospital staff and visitors are prone to touch these surfaces and, if contaminated, increase the risk of self-infection and transmission of pathogens to others ( Facciola et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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MoWa: A Disinfectant for Hospital Surfaces Contaminated With Methicillin-Resistant Staphylococcus aureus (MRSA) and Other Nosocomial Pathogens

Gregory

Ellis

Valeriani

et al. 2021

Front. Cell. Infect. Microbiol.

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IntroductionStaphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA), are a main cause of nosocomial infection in the world. The majority of nosocomial S. aureus-infection are traced back to a source of contaminated surfaces including surgery tables. We assessed the efficacy of a mixture of levulinic acid (LA) and sodium dodecyl sulfate (SDS), hereafter called MoWa, to eradicate nosocomial pathogens from contaminated surfaces.Methods and ResultsA dose response study demonstrated that MoWa killed 24 h planktonic cultures of S. aureus strains starting at a concentration of (LA) 8.2/(SDS) 0.3 mM while 24 h preformed biofilms were eradicated with 32/1.3 mM. A time course study further showed that attached MRSA bacteria were eradicated within 4 h of incubation with 65/2 mM MoWa. Staphylococci were killed as confirmed by bacterial counts, and fluorescence micrographs that were stained with the live/dead bacterial assay. We then simulated contamination of hospital surfaces by inoculating bacteria on a surface prone to contamination. Once dried, contaminated surfaces were sprayed with MoWa or mock-treated, and treated contaminated surfaces were swabbed and bacteria counted. While bacteria in the mock-treated samples grew at a density of ~104 cfu/cm2, those treated for ~1 min with MoWa (1.0/0.04 M) had been eradicated below limit of detection. A similar eradication efficacy was obtained when surfaces were contaminated with other nosocomial pathogens, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, or Staphylococcus epidermidis.ConclusionsMoWa kills planktonic and biofilms made by MRSA and MSSA strains and showed great efficacy to disinfect MRSA-, and MSSA-contaminated, surfaces and surfaces contaminated with other important nosocomial pathogens.

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Contamination of healthcare environment by carbapenem-resistant Acinetobacter baumannii

Cruz-López

Martínez-Meléndez²,

Villarreal-Treviño³

et al. 2022

The American Journal of the Medical Sciences

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Dynamics of colonization in patients with health care-associated infections at step-down care units from a tertiary care hospital in Mexico

Cited by 9 publications

References 26 publications

Microbial diversity and colonization patterns of two step-down care units from a tertiary care hospital

Microbial diversity and colonization patterns of two step-down care units from a tertiary care hospital

MoWa: A Disinfectant for Hospital Surfaces Contaminated With Methicillin-Resistant Staphylococcus aureus (MRSA) and Other Nosocomial Pathogens

Contamination of healthcare environment by carbapenem-resistant Acinetobacter baumannii

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