Dynamics of Dual Infection with Campylobacter jejuni Strains in Chickens Reveals Distinct Strain-to-Strain Variation in Infection Ecology

Chaloner, Gemma; Wigley, Paul; Humphrey, Suzanne; Kemmett, Kirsty; Lacharme-Lora, Lizeth; Humphrey, Tom J.; Williams, Nicola

doi:10.1128/aem.01901-14

Cited by 55 publications

(36 citation statements)

References 38 publications

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“…Unlike poultry and livestock production, rabbits are usually reared in wire mesh flooring cages, which avoid the contact between animals and faeces, thus reducing the risk of oral-faecal transmission of pathogens (Piccirillo et al, 2011). In poultry, the high-level faecal shedding combined with the coprophagic behaviour of chickens means that once the first bird in a broiler flock becomes colonised, the bacterium then is able to rapidly infect the entire flock in just a few days (Chaloner et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Short communication: Absence of campylobacter spp. In intensive rabbit farming in eastern Spain, preliminary results

2016

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Campylobacteriosis and salmonellosis are the most frequently reported zoonoses and among the most common causes of diarrhoeal illness in the European Union and the United States, and their incidence appears to be increasing. Campylobacter species are routinely found in poultry, swine, cattle, dairy cows and sheep. So far, there are few descriptions of Campylobacter isolation from rabbits. Rabbit meat is a common item in the Mediterranean diet. In this context, the aim of the present study was to investigate the occurrence of Campylobacter spp. in healthy rabbits reared in intensive farms in the Alto Palancia region, eastern Spain. Caecal contents from 70 healthy does reared on 7 different farms were collected. Bacteriological culture was performed in accordance with ISO 10272-1:2006. All samples tested negative for Campylobacter spp. To our knowledge, this is the first study in which comprehensive monitoring was specifically carried out in order to provide data on the occurrence of thermophilic Campylobacter spp. in large intensive rabbit farms in Spain. However, further microbiological studies throughout the Spanish territory are needed to determine the prevalence and risk of other foodborne pathogens in rabbits at farm level.

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Section: Resultsmentioning

confidence: 99%

Short communication: Absence of campylobacter spp. In intensive rabbit farming in eastern Spain, preliminary results

2016

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“…This initial resistance to infection appears to be related to maternally derived immunity, although newly-hatched chicks can be colonized (Boyed, Herbert, Marston, Jones, & Barrow, 2005). There is some evidence for Campylobacter strain-associated differences in colonization potential in broilers (Chaloner et al, 2014). Little is known about transmission between various kinds of livestock (Table 1).…”

Section: Identification and Subtypingmentioning

confidence: 99%

Knowledge gaps in control ofCampylobacterfor prevention of campylobacteriosis

Hansson

Sandberg

Habib

et al. 2018

Transbound Emerg Dis

144

112

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Campylobacteriosis is an important, worldwide public health problem with numerous socio-economic impacts. Since 2015, approximately 230,000 cases have been reported annually in Europe. In the United States, Australia and New Zealand, campylobacteriosis is the most commonly reported disease. Poultry and poultry products are considered important sources of human infections. Poultry meat can become contaminated with Campylobacter during slaughter if live chickens are intestinal carriers. Campylobacter spp. can be transferred from animals to humans through consumption and handling of contaminated food products, with fresh chicken meat being the most commonly implicated food type. Regarding food-borne disease, the most important Campylobacter species are Campylobacter jejuni and Campylobacter coli. In humans, clinical signs of campylobacteriosis include diarrhoea, abdominal pain, fever, headache, nausea and vomiting. Most cases of campylobacteriosis are sporadic and self-limiting, but there are post-infection complications, for example, Guillain-Barrés syndrome. This review summarizes an analysis undertaken by the DISCONTOOLS group of experts on campylobacteriosis. Gaps were identified in: (i) knowledge of true number of infected humans; (ii) mechanisms of pathogenicity to induce infection in humans; (iii) training to prevent transfer of Campylobacter from raw to ready-to-eat food; (iv) development of effective vaccines; (v) understanding transmission routes to broiler flocks; (vi) knowledge of bacteriocins, bacteriophages and antimicrobial peptides as preventive therapies; (vii) ration formulation as an effective preventive measure at a farm level; (viii) development of kits for rapid detection and quantification of Campylobacter in animals and food products; and (ix) development of more effective antimicrobials for treatment of humans infected with Campylobacter. Some of these gaps are relevant worldwide, whereas others are more related to problems encountered with Campylobacter in industrialized countries.

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“…Often only one time point post C. jejuni inoculation was investigated not considering the dynamics of colonization [17, 24]. …”

Section: Introductionmentioning

confidence: 99%

Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken

Han¹,

Willer²,

Pielsticker³

et al. 2016

Gut Pathog

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BackgroundChickens are regarded as the main reservoir for human campylobacteriosis. Little is known about the interaction between Campylobacter jejuni (C. jejuni) and chickens. This interaction may be influenced by the stage of maturation of the immune system, developing gut microbiota composition and other factors including breed and diet. Our aim was to investigate the impact of breed, and diet on C. jejuni colonization and host immune responses in chickens. Birds were inoculated with 104 colony forming units (CFU) of C. jejuni or diluent at one (Exp. 1) or 22 (Exp. 2) days post hatch. We compared local immune cell subpopulations, cytokine expression levels, and gut microbiota composition between broiler-type (BT) and layer-type (LT) birds fed with either commercial broiler feed (bf) or layer feed (lf).ResultsLower colonization rates were observed in the older age group independent of breed and diet. Independent of breed, birds fed with bf showed higher CFU of C. jejuni compared to lf-fed groups. Campylobacter jejuni-inoculation had a significant effect on lymphocyte numbers and cytokine expression levels in BT birds independent of feeding strategy (p < 0.05). These effects were not detected in LT birds, only LT birds fed with bf showed a significant increase in IL-8-expression at 7 days post C. jejuni inoculation compared to LT-control birds (p < 0.05). Diet influenced gut microbiota composition in a comparable manner between BT and LT birds, but changes in microbiota composition associated with C. jejuni inoculation varied between breeds.ConclusionsDiet and breed influenced C. jejuni colonization, immune responses and microbiota composition to a different extent comparing between LT and BT birds. The mechanisms behind these differences have to be elucidated further. Our results suggest that selection for more resistant breeds in combination with adapted feeding strategies may help to reduce Campylobacter colonization levels in commercial poultry in the future.

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Dynamics of Dual Infection with Campylobacter jejuni Strains in Chickens Reveals Distinct Strain-to-Strain Variation in Infection Ecology

Cited by 55 publications

References 38 publications

Short communication: Absence of campylobacter spp. In intensive rabbit farming in eastern Spain, preliminary results

Short communication: Absence of campylobacter spp. In intensive rabbit farming in eastern Spain, preliminary results

Knowledge gaps in control ofCampylobacterfor prevention of campylobacteriosis

Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken

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