Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome

Alexandrova, Margarita L.; Bochev, Petyo G.; Markova, Vanya I.; Bechev, Blagovest; Попова, Марина Алексеевна; Danovska, Maya P.; Simeonova, Virginia K.

doi:10.1016/j.jocn.2003.10.015

Cited by 56 publications

(30 citation statements)

References 25 publications

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“…In human total blood catalase and GPx activities did not reflect the severity of neurological deficit (Alexandrova et al, 2004). However, the ischemic patients' blood showed significantly higher catalase and GPx activity in comparison to the control group.…”

Section: Catalase Activitymentioning

confidence: 77%

“…Strand and Marklund (1992) reported good correlation between the increased Cu,Zn-SOD activity in CSF with the size of the infarct and functional impairment. Besides, the SOD activity has been monitored in human erythrocytes at IS, and the decrease (Demirkaya et al, 2001) or no modification (Alexandrova et al, 2004) has been observed.…”

Section: A S T O E N D O G E N O U S S O D L E V E L O R a C T I V I mentioning

confidence: 99%

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Plasma Antioxidant Activity as a Marker for a Favourable Outcome in Acute Ischemic Stroke

Sapojnikova¹,

Asatiani²,

Kartvelishvili³

et al. 2012

Antioxidant Enzyme

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Section: Catalase Activitymentioning

confidence: 77%

Section: A S T O E N D O G E N O U S S O D L E V E L O R a C T I V I mentioning

confidence: 99%

Plasma Antioxidant Activity as a Marker for a Favourable Outcome in Acute Ischemic Stroke

Sapojnikova¹,

Asatiani²,

Kartvelishvili³

et al. 2012

Antioxidant Enzyme

View full text Add to dashboard Cite

“…This increase in glutamate could be allied to increasing release from neurons, resulting from energy failure, or to reducing clearance of glutamate by glial transporters. An increased production of free radicals and other reactive species in stroke leads to oxidative stress [6]. Stroke (ischemia) causes a cascade of events that can induce glutamate release and increased free radical production via several different pathways [7].…”

Section: Strokementioning

confidence: 99%

Protective functions of AEURA in Cell Based Model of Stroke and Alzheimer disease

Jang-Yen¹

2017

J Neurosci Neurol Disord

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Stroke and neurodegenerative diseases including Alzheimer's disease (AD) are responsible for a major proportion of mortalities in the elderly. We have previously investigated novel mechanism-based therapies of AEURA in cell culture models against viral infection and in glutamate excitotoxity. In our new studies, we propose that the homeopathic formula AEURA could serve as a potential therapeutic agent for stroke & for AD. In examining AEURA treatment of PC12 cells exposed to glutamate excitotoxicity, hypoxia /re-oxygenation injury and A-Beta toxicity. We demonstrated an increased survival rate in AEURA treated cells by comparison to control cells. In examining the therapeutic potential of AEURA in PC12 cells this homeopathic agent was found to be neuroprotective against either glutamate induced toxicity, hypoxia /re-oxygenation stress or cell stress resulting from viral infection (with either HSV-1 or rhinovirus). Our ongoing studies involve examining the neuroprotective potential AEURA in vivo using rodent models of stroke & AD.

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“…In the patients that have suffered stroke, neuronal death is caused by the free radicals arising from various sources, such as xanthine oxidase, cyclooxygenase, inflammatory cells and mitochondria [86]. The mitochondrial electron transport chain is altered during ischemia and reperfusion and is also a likely source of free radicals.…”

Section: Strokementioning

confidence: 99%

Review Article: Oxidative Stress Versus Antioxidants

Al-Dalaen¹

2014

BIO

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Abstract:Oxidative stress is a phenomenon that reflects an imbalance between the production of reactive oxygen species and so-called oxidants, and their elimination by protective mechanisms. These are referred to as antioxidative systems which can detoxify the reactive intermediates, or repair the resulting damage causing toxic effects through the production of peroxides and free radicals that damage all cell components. Further, some reactive oxidative species act as cellular messengers in redox signaling that can cause disruptions in normal cellular signaling mechanisms. In humans, oxidative stress is thought to be involved in the development of atherosclerosis, neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, cancer, diabetes mellitus, inflammatory diseases, as well as psychological diseases or aging processes. It is presently accepted that the reactive oxygen species can be beneficial. Depending on the type of oxidants, intensity and time of redox imbalance, as well as on the type of cells, oxidative stress can play a role in the regulation of other important processes. This is achieved through modulation of signal pathways, influencing synthesis of antioxidant enzymes, repair processes, inflammation, or via the immune system, as a way to attack and kill pathogens. This limits the potential for apoptosis and cell proliferation, and thus affects malignant processes. Imprudent administration of antioxidants may therefore have a negative impact on the organism.

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Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome

Cited by 56 publications

References 25 publications

Plasma Antioxidant Activity as a Marker for a Favourable Outcome in Acute Ischemic Stroke

Plasma Antioxidant Activity as a Marker for a Favourable Outcome in Acute Ischemic Stroke

Protective functions of AEURA in Cell Based Model of Stroke and Alzheimer disease

Review Article: Oxidative Stress Versus Antioxidants

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