Dynamics of glomerular ultrafiltration: VI. Studies in the primate

Maddox, David A.; Deen, William M.; Brenner, Barry M.; Troy, Julia L.; Surface, Robert W.

doi:10.1038/ki.1974.36

Cited by 46 publications

(24 citation statements)

References 27 publications

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“…7 The central role of increased perfusion in the early functional adaptation in humans is supported by the observed increase in renal plasma flow (RPF) after nephrectomy, of a magnitude similar to or greater than the percentage change in GFR (Table 1). 2,3,5,8 To investigate the hemodynamic mechanisms whereby GFR increases after nephrectomy, renal functional reserve capacity (RFR), defined as percentage increase in GFR after infusion of lowdose dopamine or amino acids, was evaluated in 15 LDs before donation and at a mean 6 SEM of 1.360.3 months and 4.960.8 years after donation (Table 1).…”

Section: Physiologic Adaptations After Uninephrectomy In Healthy Donorsmentioning

confidence: 81%

The Natural History of Residual Renal Function in Transplant Donors

Mueller

Luyckx

2012

Journal of the American Society of Nephrology

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After uninephrectomy, GFR in the remaining kidney increases to 60%-70% of the predonation value, largely because of a substantial increase in renal blood flow. Donor kidney function is then generally maintained over many years. Hypertension and proteinuria are common among living donors but do not appear to negatively affect long-term renal function. Loss of reserve capacity regarding renal function in some subgroups after donation, particularly in obese and older donors, raises questions about limitations of the renal adaptive response and suggests caution in generalization of current outcome data to more marginal donors not well represented in older studies.

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Section: Physiologic Adaptations After Uninephrectomy In Healthy Donorsmentioning

confidence: 81%

The Natural History of Residual Renal Function in Transplant Donors

Mueller

Luyckx

2012

Journal of the American Society of Nephrology

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“…To obtain estimates of colloid osmotic pressure (7r) of plasma entering and leaving glomerular capillaries, protein concentrations (C) in femoral arterial and efferent arteriolar blood plasma were measured as described previously (1)(2)(3)(4)(5)(6). C measured in femoral arterial plasma was taken as representative of C for the afferent arteriole.…”

Section: Methodsmentioning

confidence: 99%

“…This restriction has been overcome, however, in that a unique strain of Wistar rats with surface glomeruli has recently been discovered, allowing direct assessment of the determinants of ultrafiltration (1)(2)(3)(4)(5). Accordingly, the present study was undertaken in an effort to examine, by using previously described micropuncture techniques (1)(2)(3)(4)(5)(6), the …”

mentioning

confidence: 99%

Determinants of glomerular filtration in experimental glomerulonephritis in the rat.

Maddox¹,

Bennett²,

Deen³

et al. 1975

J. Clin. Invest.

118

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“…A major step forward came from an alliance with Channing Robertson, a young faculty member in the Department of Chemical Engineering at nearby Stanford University, and his eager graduate students, William Deen, Ramsay Chang, and Michael Bohrer. We developed a mathematical model of glomerular ultrafiltration (5) and confirmed a series of functional predictions in followup studies (the so-called Glomerular Dynamics series) of autoregulatory mechanisms, quantification of the ultrafiltration coefficient, responses to ischemic and ablative renal injury, and extension of servo-null methodology to the kidney of the primate (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Mechanisms Of Normal Glomerular Functionmentioning

confidence: 99%

Remission of renal disease: recounting the challenge, acquiring the goal

Brenner¹

2002

J. Clin. Invest.

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Renal excretory function begins at the glomerular capillaries with the formation of a nearly ideal ultrafiltrate of plasma. The volume and composition of the ultrafiltrate undergo sequential change along the nephron, ultimately regulated to preserve near-constancy of mineral, electrolyte, and fluid balance. Modest derangement of these processes often escapes clinical or laboratory detection, because the myriad of unimpaired nephrons compensate more or less completely. Beyond a certain level of injury, however, compensatory adaptations no longer keep pace with nephron loss. As a result, glomerular filtration rate declines and organic nitrogenous wastes (e.g., creatinine, urea) accumulate in plasma and other body fluids. In acute renal failure, injury is usually transient, so that deterioration of function is short-lived and reversible. Not so, however, with the many forms of irreversible nephron damage, which typically progress over time, often eventuating in complete loss of renal function, systemic toxicity (uremia), and death unless the lost function is replaced by chronic dialysis and/or successful renal transplantation. Much of the effort in nephrology since the 1970s has been concerned with improving the effectiveness of these renal-replacement therapies. In the late 1960s, we fortuitously gained access to a unique strain of rats with many glomeruli that are situated on the renal cortical surface. For the first time, mammalian glomeruli were therefore accessible to direct study by new microtechniques developed in our laboratory. We therefore addressed the following questions: (a) What are the precise hemodynamic forces and biophysical properties that govern glomerular capillary function in health? (b) How are these elements modified during renal injury? (c) Do these modifications contribute to the relentless progression of renal disease? (d) If so, can they be reversed, so as to retard further deterioration of renal function and prevent end-stage renal disease (ESRD)?

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Dynamics of glomerular ultrafiltration: VI. Studies in the primate

Cited by 46 publications

References 27 publications

The Natural History of Residual Renal Function in Transplant Donors

The Natural History of Residual Renal Function in Transplant Donors

Determinants of glomerular filtration in experimental glomerulonephritis in the rat.

Remission of renal disease: recounting the challenge, acquiring the goal

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