Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study

Wu, Min; Chi, Cheng; Yang, Yongjian; Guo, Shan; Li, Tianhe; Gu, Muqing; Zhang, Tingting; Gao, Huimin; Liu, Ruixia; Yin, Chenghong

doi:10.1186/s12884-022-04923-5

Cited by 7 publications

(6 citation statements)

References 48 publications

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“…In addition, phylum Actinobacteria and genus Lachnospiraceae UCG008, both protective in this study, are implicated in human sugar and protein metabolism. Phylum Actinobacteria participates in the biosynthesis of phenylalanine, tyrosine, and tryptophan, whereas Lachnospiraceae UCG008 is associated with alanine, aspartate, and glutamate metabolism (52)(53)(54). Our results also identified Ruminiclostridium5 as a risk for promoting hypothyroidism.…”

Section: Discussionmentioning

confidence: 50%

Complex relationship between gut microbiota and thyroid dysfunction: a bidirectional two-sample Mendelian randomization study

Liu,

Zhang

et al. 2023

Front. Endocrinol.

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BackgroundMany studies have reported the link between gut microbiota and thyroid dysfunction. However, the causal effect of gut microbiota on thyroid dysfunction and the changes in gut microbiota after the onset of thyroid dysfunction are not clear.MethodsA two-sample Mendelian randomization (MR) study was used to explore the complex relationship between gut microbiota and thyroid dysfunction. Data on 211 bacterial taxa were obtained from the MiBioGen consortium, and data on thyroid dysfunction, including hypothyroidism, thyroid-stimulating hormone alteration, thyroxine deficiency, and thyroid peroxidase antibodies positivity, were derived from several databases. Inverse variance weighting (IVW), weighted median, MR-Egger, weighted mode, and simple mode were applied to assess the causal effects of gut microbiota on thyroid dysfunction. Comprehensive sensitivity analyses were followed to validate the robustness of the results. Finally, a reverse MR study was conducted to explore the alteration of gut microbiota after hypothyroidism onset.ResultsOur bidirectional two-sample MR study revealed that the genera Intestinimonas, Eubacterium brachy group, Ruminiclostridium5, and Ruminococcaceae UCG004 were the risk factors for decreased thyroid function, whereas the genera Bifidobacterium and Lachnospiraceae UCG008 and phyla Actinobacteria and Verrucomicrobia were protective. The abundance of eight bacterial taxa varied after the onset of hypothyroidism. Sensitivity analysis showed that no heterogeneity or pleiotropy existed in the results of this study.ConclusionThis novel MR study systematically demonstrated the complex relationship between gut microbiota and thyroid dysfunction, which supports the selection of more targeted probiotics to maintain thyroid–gut axis homeostasis and thus to prevent, control, and reverse the development of thyroid dysfunction.

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Section: Discussionmentioning

confidence: 50%

Complex relationship between gut microbiota and thyroid dysfunction: a bidirectional two-sample Mendelian randomization study

Liu,

Zhang

et al. 2023

Front. Endocrinol.

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“…It is reported that members of the family Lachnospiraceae have a wide range of metabolic functions, including the synthesis of short chain fatty acids (including raw propionate, butyrate and other metabolites), the degradation of mucin, and the metabolism of sugar and aromatic amino acids. 35 , 36 , 37 They are negatively correlated with the concentration of pro‐inflammatory cytokines, and are related to the inflammatory remission of IBD. Members of the family Lachnospiraceae play an active role in intestinal homeostasis.…”

Section: Discussionmentioning

confidence: 99%

New insights into the interactions between the gut microbiota and the inflammatory response to ulcerative colitis in a mouse model of dextran sodium sulfate and possible mechanisms of action for treatment with PE&AFWE

Fu,

Ma,

et al. 2024

Anim Models and Exp Med

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BackgroundInflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation. Intestinal innate immunity, including innate immune cells, defends against pathogens and excessive entry of gut microbiota, while preserving immune tolerance to resident intestinal microbiota, and may be characterized by its capacity to produce a rapid and nonspecific reaction. The association between microbiota dysbiosis and the pathogenesis of IBD is complex and dynamic. When the intestinal ecosystem is in dysbiosis, the reduced abundance and diversity of intestinal gut microbiota make the host more vulnerable to the attack of exogenous and endogenous pathogenic gut microbiota. The aim of our study was to comprehensively assess the relationship between microbial populations within UC, the signaling pathways of pathogenic gut microbe therein and the inflammatory response, as well as to understand the effects of using PE&AFWE (poppy extract [Papaver nudicaule L.] and Artemisia frigida Willd. extract) on UC modulation.MethodsA UC mouse model was established by inducing SPF‐grade C57BL/6 mice using dextrose sodium sulfate (DSS). Based on metagenomic sequencing to characterize the gut microbiome, the relationship between gut microbiota dysbiosis and gut microbiota was further studied using random forest and Bayesian network analysis methods, as well as histopathological analysis.Results(1) We found that the 5 gut microbiota with the highest relative abundance of inflammatory bowel disease UC model gut microbiota were consistent with the top 5 ranked natural bacteria. There were three types of abundance changes in the model groups: increases (Chlamydiae/Proteobacteria and Deferribacteres), decreases (Firmicutes), and no significant changes (Bacteroidetes). The UC model group was significantly different from the control group, with 1308 differentially expressed species with abundance changes greater than or equal to 2‐fold. (2) The proportion of the fecal flora in the UC group decreased by 37.5% in the Firmicutes and increased by 14.29% in the proportion of Proteobacteria compared to the control group before treatment. (3) The significantly enriched and increased signaling pathways screened were the ‘arachidonic acid metabolic pathway’ and the ‘phagosomal pathway’, which both showed a decreasing trend after drug administration. (4) Based on the causal relationship between different OTUs and the UC model/PE&AFWE administration, screening for directly relevant OTU networks, the UC group was found to directly affect OTU69, followed by a cascade of effects on OTU12, OTU121, OTU93, and OTU7, which may be the pathway of action that initiated the pathological changes in normal mice. (5) We identified a causal relationship between common differentially expressed OTUs and PE&AFWE and UC in the pre‐ and post‐PE&AFWE‐treated groups. Thereby, we learned that PE&AFWE can directly affect OTU90, after which it inhibits UC, inhibiting the activity of arachidonic acid metabolic pathway by affecting OTU118, which in turn inhibits the colonization of gut microbiota by OTU93 and OTU7. (6) Histopathological observation and scoring (HS) of the colon showed that there was a significant difference between the model group and the control group (p < 0.001), and that there was a significant recovery in both the sulfasalazine (SASP)and the PE&AFWE groups after the administration of the drug (p < 0.0001).ConclusionWe demonstrated causal effects and inflammatory metabolic pathways in gut microbiota dysbiosis and IBD, with five opportunistic pathogens directly contributing to IBD. PE&AFWE reduced the abundance of proteobacteria in the gut microbiota, and histopathology showed significant improvement.

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“…In pregnant women, levothyroxine (LT4) treatment alters the abundance of various bacteria in thyroid peroxidase antibodies (TPOAb)‐positive subclinical hypothyroidism (SCH). This includes an enrichment of Blautia , Streptococcus salivarius , and Bifidobacterium longum in third trimester and a depletion of Bacteroidota, Bacteroidales, Bacteroidia, and Prevotella in second trimester, as well as Agathobacter in third trimester [ 63 ]. Xie et al, through Mendelian randomization analysis, determined that specific gut microbiota categories may play an etiological role in thyroid function at the genetic level and could potentially become effective biomarkers for the early diagnosis of thyroid‐related diseases.…”

Section: Interregulation Of Gut Microbiota and Pregnancy‐related Horm...mentioning

confidence: 99%

Intestinal flora and pregnancy complications: Current insights and future prospects

Tian,

Zhang,

Yao

et al. 2024

iMeta

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Numerous studies have demonstrated the pivotal roles of intestinal microbiota in many physiopathological processes through complex interactions with the host. As a unique period in a woman's lifespan, pregnancy is characterized by changes in hormones, immunity, and metabolism. The gut microbiota also changes during this period and plays a crucial role in maintaining a healthy pregnancy. Consequently, anomalies in the composition and function of the gut microbiota, namely, gut microbiota dysbiosis, can predispose individuals to various pregnancy complications, posing substantial risks to both maternal and neonatal health. However, there are still many controversies in this field, such as “sterile womb” versus “in utero colonization.” Therefore, a thorough understanding of the roles and mechanisms of gut microbiota in pregnancy and its complications is essential to safeguard the health of both mother and child. This review provides a comprehensive overview of the changes in gut microbiota during pregnancy, its abnormalities in common pregnancy complications, and potential etiological implications. It also explores the potential of gut microbiota in diagnosing and treating pregnancy complications and examines the possibility of gut‐derived bacteria residing in the uterus/placenta. Our aim is to expand knowledge in maternal and infant health from the gut microbiota perspective, aiding in developing new preventive and therapeutic strategies for pregnancy complications based on intestinal microecology.

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Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study

Cited by 7 publications

References 48 publications

Complex relationship between gut microbiota and thyroid dysfunction: a bidirectional two-sample Mendelian randomization study

Complex relationship between gut microbiota and thyroid dysfunction: a bidirectional two-sample Mendelian randomization study

New insights into the interactions between the gut microbiota and the inflammatory response to ulcerative colitis in a mouse model of dextran sodium sulfate and possible mechanisms of action for treatment with PE&AFWE

Intestinal flora and pregnancy complications: Current insights and future prospects

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