Dynamics of Hepatitis C Viral Load With Optimal Control Treatment Strategy

Adaptive Control Strategy for Treatment of Hepatitis C Infection

“…Although the simulation study shows the effectiveness of the proposed treatment strategy, it is desirable to test it on real patients. So far all suggested treatment strategies have been evaluated via simulation study − and to the best of authors’ knowledge no real application has been reported. We hope that, in the future, there will be a chance to apply the proposed control treatments in the literature to real patients.…”

“…To check the accuracy of Dahari model, Snoeck has compared the predicted values obtained from the model with the clinical data and showed that it has a good prediction capability. Also many references − have been proposed treatment strategies for hepatitis C infection based on the Neumann or Dahari model as a suitable representation of disease dynamics.…”

“…Control theories have been extensively utilized in biological systems, , for example for HIV − and HCV treatments. − Chakrabarty and Joshi presented a treatment strategy for combination therapy based on offline optimal control strategy. An objective function has been established in order to minimize the viral load and side effects of drugs.…”

Observer‐based controller for treatment of hepatitis C infection using fractional order model

“…Due to the dangers of the disease progress towards liver cancer and death, many researches have been carried out to propose effective treatment strategies for HCV infection by using different control strategies. [36][37][38][39][40][41][42][43] In previous works, [36][37][38][39][40] offline optimal control has been utilized to design effective methods for the HCV treatment. In these works, objective functions have been considered to minimize viral load, infected cells, and drug side effects.…”

Observer-Based Impulsive Controller Design for Treatment of Hepatitis C Disease

“…The Neumann model, as the most common mathematical model of HCV, as well as the PK/PD equations have been utilized to simulate the behaviors of the hepatitis-C-infected patients. The control objective is to reduce the viral load to a threshold that is called the cure boundary. , Different control strategies have been proposed for the treatment of hepatitis C infection. − Chakrabarty et al , presented the treatment methods for the monotherapy, as well as the combination therapy, by considering an objective function and minimizing the viral load, number of infected cells, and the drug side effects. Also, a control technique has been proposed for hepatitis C disease by considering the role of the immune system on the viral load decline.…”