Dynamics of Hippocampal Neurogenesis in Adult Humans

Spalding, Kirsty L.; Bergmann, Olaf; Alkass, Kanar; Bernard, Samuel; Salehpour, Mehran; Huttner, Hagen B.; Boström, Emil Viñas; Westerlund, Isabelle; Vial, Céline; Buchholz, Bruce A.; Possnert, Göran; Mash, Deborah C.; Druid, Henrik; Frisén, Jonas

doi:10.1016/j.cell.2013.05.002

Cited by 1,607 publications

(1,345 citation statements)

References 51 publications

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“…However, given the low number of new neurogenic cells produced in adulthood (Spalding et al, 2013), dendritic remodeling, synapse turnover, increased glial cell, and capillary density rather than neuronal replacement may account for ECT-induced volumetric changes (Bessa et al, 2009). Accordingly, Nordgren et al (2013) hypothesized that ECT causes transient downregulation of the key molecules needed to stabilize synaptic structures and to prevent calcium influx, and a simultaneous increase in neurotrophic factors, thus providing a short window of increased structural synaptic plasticity.…”

Section: Time Course Of Ect-induced Hippocampal Volume Changesmentioning

confidence: 99%

Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Bouckaert

Dols

Emsell

et al. 2016

Neuropsychopharmacol

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Recent structural imaging studies have described hippocampal volume changes following electroconvulsive therapy (ECT). It has been proposed that serum brain-derived neurotrophic factor (sBDNF)-mediated neuroplasticity contributes critically to brain changes following antidepressant treatment. To date no studies have investigated the relationship between changes in hippocampal volume, mood, and sBDNF following ECT. Here, we combine these measurements in a longitudinal study of severe late-life unipolar depression (LLD). We treated 88 elderly patients with severe LLD twice weekly until remission (Montgomery-Åsberg Depression Rating Scale (MADRS) o10). sBDNF and MADRS were obtained before ECT (T0), after the sixth ECT (T1), 1 week after the last ECT (T2), 4 weeks after the last ECT (T3), and 6 months after the last ECT (T4). Hippocampal volumes were quantified by manual segmentation of 3T structural magnetic resonance images in 66 patients at T0 and T2 and in 23 patients at T0, T2, and T4. Linear mixed models (LMM) were used to examine the evolution of MADRS, sBDNF, and hippocampal volume over time. Following ECT, there was a significant decrease in MADRS scores and a significant increase in hippocampal volume. Hippocampal volume decreased back to baseline values at T4. Compared with T0, sBDNF levels remained unchanged at T1, T2, and T3. There was no coevolution between changes in MADRS scores, hippocampal volume, and sBDNF. Hippocampal volume increase following ECT is an independent neurobiological effect unrelated to sBDNF and depressive symptomatology, suggesting a complex mechanism of action of ECT in LLD.

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Section: Time Course Of Ect-induced Hippocampal Volume Changesmentioning

confidence: 99%

Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Bouckaert

Dols

Emsell

et al. 2016

Neuropsychopharmacol

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“…In the mouse neocortex, inheritance of the mother centriole maintains stemness; interfering with this process causes premature depletion of progenitors from the proliferative zone [79]. Why is this so?…”

Section: (Iii) Centrosome Asymmetry and Ciliogenesismentioning

confidence: 99%

Small organelle, big responsibility: the role of centrosomes in development and disease

Chavali

Pütz

Gergely

2014

Phil. Trans. R. Soc. B

140

111

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The centrosome, a key microtubule organizing centre, is composed of centrioles, embedded in a protein-rich matrix. Centrosomes control the internal spatial organization of somatic cells, and as such contribute to cell division, cell polarity and migration. Upon exiting the cell cycle, most cell types in the human body convert their centrioles into basal bodies, which drive the assembly of primary cilia, involved in sensing and signal transduction at the cell surface. Centrosomal genes are targeted by mutations in numerous human developmental disorders, ranging from diseases exclusively affecting brain development, through global growth failure syndromes to diverse pathologies associated with ciliary malfunction. Despite our much-improved understanding of centrosome function in cellular processes, we know remarkably little of its role in the organismal context, especially in mammals. In this review, we examine how centrosome dysfunction impacts on complex physiological processes and speculate on the challenges we face when applying knowledge generated from in vitro and in vivo model systems to human development.

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“…However, in the most recent work of Spalding et al [22] neurogenesis throughout adulthood was found in the human hippocampus, adding to the plasticity of this important part of the brain (Fig. 7).…”

Section: Dating Human Dna With the 14 C Bomb Peakmentioning

confidence: 77%

Accelerator mass spectrometry – from DNA to astrophysics

Kutschera

2013

EPJ Web of Conferences

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Abstract.A brief review of accelerator mass spectrometry (AMS) is presented. The present work touches on a few technical aspects and recent developments of AMS, and describes two specific applications of AMS, the dating of human DNA with the 14 C bomb peak and the search for superheavy elements in nature. Since two extended general reviews on technical developments in AMS [1] and applications of AMS [2] will appear in 2013, frequent reference to these reviews is made.

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Dynamics of Hippocampal Neurogenesis in Adult Humans

Cited by 1,607 publications

References 51 publications

Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression

Small organelle, big responsibility: the role of centrosomes in development and disease

Accelerator mass spectrometry – from DNA to astrophysics

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