Dynamics of in Vivo Metabolites Concentrations in Posttraumatic Period of Human Brain. 1H MRS Study

Semenova, N. A.; Menshchikov, Petr; Манжурцев, А. В.; Ublinskiy, M. V.; Ахадов, Т. А.; Varfolomeev, S. D.

doi:10.1134/s1607672919010071

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Second, although less often examined, other metabolites such as lactate, 31 , 50 , 78 , 92 , 100 , 104 , 114 , 121 , 140 , 143 , 153 γ-aminobutyric acid (GABA), 3 , 86 , 95 , 143 , 154 , 158 glutathione, 27 , 64 , 90 and aspartate 109 , 130 , 143 have been measured using 1 H MRS in brain injury. As many of these metabolites are present in low concentrations and some have complex signal patterns, reliable quantification requires advanced MRS methods, typically spectral editing.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta–Analysis

Joyce

Walker

et al. 2022

Journal of Neurotrauma

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Magnetic resonance spectroscopy (MRS) is a non-invasive technique used to study metabolites in the brain. MRS findings in traumatic brain injury (TBI) and subconcussive hit literature have been mixed. The most common observation is a decrease in N -acetyl-aspartate (NAA), traditionally considered a marker of neuronal integrity. Other metabolites, however, such as creatine (Cr), choline (Cho), glutamate+glutamine (Glx) and myo -inositol (mI) have shown inconsistent changes in these populations. The objective of this systematic review and meta-analysis was to synthesize MRS literature in brain injury and explore factors (biological factors such as brain region, injury severity, time since injury, demographics and technical methodological factors such as field strength, acquisition parameters, analysis approach) that may contribute to differential findings. One hundred and thirty-eight studies met inclusion criteria for the systematic review and of those, 62 NAA, 24 Cr, 49 Cho, 18 Glx, and 21 mI studies met inclusion criteria for meta-analysis. A random effects model was used for meta-analyses with brain region as a subgroup for each of the five metabolites studied. Meta-regression was used to examine the influence of potential moderators including injury severity, time since injury, age, sex, tissue composition, and methodological factors. In this analysis of 1428 unique brain-injured subjects and 1132 controls, the corpus callosum was identified as a brain region highly susceptible to metabolite alteration. NAA was consistently decreased in TBI of all severities, but not in subconcussive hits. Cho and mI were found to be increased in moderate-to-severe TBI but not in mild TBI. Glx and Cr were largely unaffected, but did show alterations in certain conditions.

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