From the last decade due to the immense development in the field of Nano-science, magnetic nanoparticles hyperthermia has been proved as one of the most reliable new tumor treatment therapy. Because of immature cells, low blood flow rate, high density and lack of oxygen environment inside the tumour, it is experimentally seen that, tumour cells at temperature between 42°C and 47°C the viability of the cancerous cells is reduced [5,14]). In order to achieve efficient and safe operational hyperthermia conditions, it is necessary to study or investigate detail about what heating model or magnetic loss processes dominant over the other in the ensemble of nanoparticles which are injected at the cancerous tumour sites. Because there are more than one heat loss process involved in generating heat by MNPs. There have numerous both theoretical and experimental work been done by different nanoparticles. Here, in this work we consider different MNPs and compare their theoretical results given by these particles. And taking into account cellular uptake mechanism since hyperthermia is intercellular process it is seen that Meghamite is the best magnetic particle to use for the hyperthermia. Using the data for meghamite we plot heat dissipation profile for different time interval inside the tumor. Comparing this result with normal tissue we have showed that hyperthermia has very low side effect on normal or healthy tissue. And at around 40 minutes it will raise the temperature of the tumor to 47 0 C, which is required for killing the tumour cell.