Dynamics of minimal residual disease defines a novel risk-classification and the role of allo-HSCT in adult Ph-negative B-cell acute lymphoblastic leukemia

Cai, Zihong; Tang, Bingqing; Wu, Zhengwei; Wang, Zhixiang; Lin, Ren; Xu, Xiuli; Huang, Zicong; Ou, Jiawang; Li, Xiaofang; Liu, Xiaoli; Liu, Qifa; Zhou, Hongsheng

doi:10.1080/10428194.2022.2115841

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…29 A previous study by our group presented multiparameter flow cytometry (MFC)based dynamics of MRD for precision classification. 30 It is important to note that both pSTAT5 expression and postinduction MRD were significant factors for survival and the risk of relapse in multivariate analysis. The novel risk stratification combining pSTAT5 with MRD discriminated distinct prognostic groups, which is reliable and easy by flow cytometry.…”

Section: Discussionmentioning

confidence: 98%

STAT5 phosphorylation plus minimal residual disease defines a novel risk classification in adult B‐cell acute lymphoblastic leukaemia

Xu,

Huang,

Ding

et al. 2024

Br J Haematol

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SummaryThe dysregulation of the Janus family tyrosine kinase‐signal transducer and activator of transcription (JAK‐STAT) is closely related to acute lymphoblastic leukaemia (ALL), whereas the clinical value of phosphorylated STAT5 (pSTAT5) remains elusive. Herein we performed a prospective study on clinical significance of flow cytometry‐based pSTAT5 in adult B‐ALL patients. A total of 184 patients were enrolled in the Precision‐Classification‐Directed‐Target‐Total‐Therapy (PDT)‐ALL‐2016 cohort between January 2018 and December 2021, and STAT5 phosphorylation was detected by flow cytometry at diagnosis. Based on flow‐pSTAT5, the population was classified into pSTAT5low (113/184, 61.1%) and pSTAT5high (71/184, 38.9%). Overall survival (OS) and event‐free survival (EFS) were inferior in pSTAT5high patients than in those with pSTAT5low (OS, 44.8% vs. 65.2%, p = 0.004; EFS, 23.5% vs. 52.1%, p < 0.001), which was further confirmed in an external validation cohort. Furthermore, pSTAT5 plus flow‐based minimal residual disease (MRD) postinduction defines a novel risk classification as being high risk (HR, pSTAT5high + MRD+), standard risk (SR, pSTAT5low + MRD−) and others as moderate‐risk group. Three identified patient subgroups are distinguishable with disparate survival curves (3‐year OS rates, 36.5%, 56.7% and 76.3%, p < 0.001), which was confirmed on multivariate analysis (hazard ratio 3.53, p = 0.003). Collectively, our study proposed a novel, simple and flow‐based risk classification by integrating pSTAT5 and MRD in favour of risk‐guided treatment for B‐ALL.

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Section: Discussionmentioning

confidence: 98%

STAT5 phosphorylation plus minimal residual disease defines a novel risk classification in adult B‐cell acute lymphoblastic leukaemia

Xu,

Huang,

Ding

et al. 2024

Br J Haematol

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“…Patients received chemotherapy or targeted drugs (TKIs and ruxolitinib) along with chemotherapy as frontline treatment. The chemotherapy regimens included Precision‐Classification‐Directed‐Target‐Total‐Therapy (PDT)‐ALL‐2016 11 , 14 , 15 (for NFH) and the Chinese guideline for the treatment of adult ALL 5 (for the other four SCHC centers). Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) was recommended for patients who achieved complete remission (CR) if a donor was available.…”

Section: Methodsmentioning

confidence: 99%

An integrated classification of tumor suppressor IKZF1 inactivation and oncogenic activation in Philadelphia chromosome‐like acute lymphoblastic leukemia

Huang,

Zhang,

Gong

et al. 2024

HemaSphere

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Philadelphia chromosome (Ph)‐like acute lymphoblastic leukemia (ALL) is recognized for its genetic and clinical diversity. In this study, we identified a novel high‐risk subset of Ph‐like ALL, characterized by the activation of oncogenic signaling and the inactivation of the tumor suppressor gene IKZF1, resulting in a dismal outcome. The association between cytogenetic aberrations and clinical features was assessed on a cohort of 191 patients with Ph‐like ALL. Our findings revealed that patients with inactivation of IKZF1 combined with activation of oncogenic signaling (CRLF2/EPOR/JAK2 rearrangements or p‐CRKL/p‐STAT5 high expression) had the worst outcome (3‐year overall survival [OS] of 28.8% vs. 80.1% for others, p < 0.001; 2‐year event‐free survival [EFS] of 6.5% vs. 57.0% for others, p < 0.001). Multivariable analysis demonstrated that this high‐risk feature was an independent inferior prognostic factor (adjusted hazard ratio for OS = 4.55, 95% confidence interval [CI]: 2.35–8.81, p < 0.001; adjusted hazard ratio for EFS = 3.27, 95% CI: 1.99–5.39, p < 0.001). Allogeneic hematopoietic stem cell transplantation was associated with improved prognoses in patients within the high‐risk subgroup. In conclusion, this study identified a clinically distinct entity that possesses effective prognostic features and provides potential guidance for refining risk stratification in Ph‐like ALL.

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“…e study [21] addressed the issues of how to reduce storage costs, fully utilize computational power, improve throughput, and support distributed nonlinear selection algorithm optimization. e study [22] pointed out that data analysis tends to use fewer fields, so the column storage rate is high, and popular databases in the industry (Bigtable, HBase) are implemented based on column storage.…”

Section: Related Workmentioning

confidence: 99%

Optimal Management of Computer Network Security in the Era of Big Data

Min-feng

2022

Journal of Computer Networks and Communications

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As the “new oil of the future,” big data is becoming the leading industry of the new economy, the core asset of the country and enterprises, the “new blue ocean” to be pursued, and the national strategy to be developed by all countries. The development of big data and its related technology supports and promotes a new round of technological innovation, making a new generation of information security technology reform and innovation, bringing opportunities and challenges to optimize, and consolidating national information security. In the era of big data, what kind of challenges and impacts will information security face? and is it crucial to explore the response strategies? At present, China has risen to become the world’s largest number of Internet users and the largest number of people using smartphones, but because China’s information security is the initial stage, involving information security, especially national information security laws and regulations are not much, the national social supervision and monitoring mechanisms are not much, the application level of science and technology content is relatively backward, the core technology has a patent technology not much, resulting in the flood of network data nowadays. Therefore, the underground illegal “data industry chain” activities are rampant. Therefore, this paper proposes a security-aware model based on the combination of distributed data analysis technology and data features. The model uses data features to dynamically generate a library of situational anomalies, effectively solving the problem of analyzing and processing rapidly and dynamically generated data streams, increasing the detection rate to more than 98%, effectively reducing the possibility of false detection, and having good results on large-scale datasets.

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Dynamics of minimal residual disease defines a novel risk-classification and the role of allo-HSCT in adult Ph-negative B-cell acute lymphoblastic leukemia

Cited by 4 publications

References 38 publications

STAT5 phosphorylation plus minimal residual disease defines a novel risk classification in adult B‐cell acute lymphoblastic leukaemia

STAT5 phosphorylation plus minimal residual disease defines a novel risk classification in adult B‐cell acute lymphoblastic leukaemia

An integrated classification of tumor suppressor IKZF1 inactivation and oncogenic activation in Philadelphia chromosome‐like acute lymphoblastic leukemia

Optimal Management of Computer Network Security in the Era of Big Data

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