Dynamics of Morphological Characteristics of the Wound Process in Patients With Odontogenic Flegmons in Antioxidant Therapy

Abstract

Aim. This research was designed to conduct a morphological analysis of the purulent wound exudate in the complex treatment of patients with odontogenic phlegmon of maxillofacial area (MA) by the antioxidant “Rexod” and antihypoxant “Mafusol”.Materials and methods. The objects of the study were 62 patients (aged 18 to 50 years) with odontogenic phlegmon who were divided into 3 groups. Group I (n=20) – the traditional treatment was supplemented by the intravenous drip injection of the antioxidant "Rexod"; group II (n=21) – the traditional treatment was combined with the intravenous injection of the antioxidant "Rexod" and antihypoxicant "Mafusol"; Group III (n=21) had the traditional treatment. The debridement of the purulent wound included a treatment with 0.06% sodium hypochlorite solution in all groups of patients in the first phase of the wound process; in the second phase the patients in all main groups were treated with the "Soderm" ointment dressings; in the comparison group were used the bandages with methyluracil ointment. In the third phase the gel "Kontraktubeks" was used to prevent the formation of rough scar tissue. There was carried out a morphological examination of smearsimprints of the wound exudate.Results. The microscopic analysis of the cellular landscape of the exudate revealed a significant number of polynuclears which are probably the segmented neutrophilic leukocytes and typical eosinophils; the number of mononuclear cells represented by typical lymphocytes was 4 times less; a single presence of macrophages, plasmocytes, fibroblast-like and epithelioid cells. The signs of degeneration were identified in the cells of histiogenic origin.Conclusion. As a result, there was revealed a gradual increase of overall amount of cells in the wound exudate in all study groups during the treatment, however, this process was pronounced to a greater extent in the patients of group I and II. The obtained result indicates the direct dependence of the activation of reparative processes in the wound from the applied medicines.

Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia

“…Taking into account the above, for our study we chose the drugs mafusol and rexod. The first one contains fumaric acid, which is part of the Krebs cycle and ensures the maintenance of energy processes in tissues at the appropriate level (Strakhov 2016;Sukhomlin et al 2016;Maevsky and Grishina 2017;Sukhomlin et al 2017); the second one, which is a recombinant human superoxide dismutase (SOD), is the first line enzyme of defense against free radicals and also has a pronounced anti-inflammatory, anti-hypoxic, cytotropic and membrane tropic activities (Shakhmardanova et al 2016;Jiang et al 2017;Biosa et al 2018;Nguyen et al 2018;Saroyan et al 2018;Shafranova et al 2018;Srivastava et al 2018;Wang et al 2018;Yoon et al 2018;Shi et al 2019;Leontev et al 2020).…”

Effects of cytoflavin on biochemical indicators in patients with maxillofacial area phlegmons

“…Большое количество исследований и обзорных материалов посвящено применению антиоксидантов в комплексном лечении гнойновоспалительных заболеваний челюстно-лицевой области [8]. В частности, обсуждается эффективность применения таких лекарственных средств, как аевит, реамберин, мексидол, рексод и других [9]. Актуальным остается изучение потенциала препаратов, содержащих янтарную кислоту, некоторыми из наиболее современных таких препаратов являются цитофлавин [10] и ремаксол [11], содержащие субстраты и кофакторы энергетического обмена [12][13][14].…”