Dynamics of Oxidative Stress Evoked by Myocardial Ischemia Reperfusion After Off-Pump Coronary Artery Bypass Grafting Elucidated by Bilirubin Oxidation

Yamamoto, Masaki; Nishimori, Hideaki; Fukutomi, Takashi; Yamaguchi, Tokio; Orihashi, Kazumasa

doi:10.1253/circj.cj-16-1116

Cited by 14 publications

(14 citation statements)

References 34 publications

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“…This finding suggests that patients with chronic schizophrenia are under a certain kind of oxidative stress, and our results also suggest that the UBP level is more associated with school stress than the 8OHdG level. 8OHdG is produced through reactions between nuclear DNA and ROS [31], whereas UBP is produced through reactions between bilirubin and ROS [12]. This difference in their production processes might underlie the greater promise of UBP as a mental stress marker [32].…”

Section: Discussionmentioning

confidence: 99%

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Reference urinary biopyrrin level and physiological variation in healthy young adults: relation of stress by learning

Tada

Shiota

Hayashi³

et al. 2020

Heliyon

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Background: Biopyrrins are end products of oxidation reactions of bilirubin with reactive oxygen, and urinary biopyrrin (UBP) levels might increase under oxidative stress. The authors examined the reference UBP level for healthy adults and its physiological variation in 40 healthy volunteers recruited from among students of our university (20 students each from third-year and fourth-year), and compared the results with data on 8-hydroxy-2deoxyguanosine (8OHdG). Methods: UBP and 8OHdG levels could be considered as oxidative stress markers. The UBP levels were measured with a competitive ELISA kit using biopyrrin antibody 24G7, according to the manufacturer's protocol. 8OHdG levels were measured with a Highly Sensitive 8-OHdG Check kit. UBP and 8OHdG measurements were performed in triplicate and means values calculated. For both parameters, creatinine (Cr) correction was performed using urinary creatinine levels measured by an enzymatic method. Results: A comparison of the UBP levels between different grades revealed that the third-year students under high stress from clinical training and other course work tended to have a higher UBP level than fourth-year students. Therefore, we compared the current UBP levels in fourth-year students (samples collected in 2018) with their UBP level when they were in the third-year (samples collected in 2017) to examine the annual change. We found that the UBP level in 2017 samples was significantly higher than that in 2018 samples (P < 0.05). No difference in the 8OHdG level. Additionally, no effect of menstrual stress on the UBP level was observed. Conclusions: These results suggest that the UBP levels may be related to school-related stress and menstruation has no effects on urinalysis results.

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Section: Discussionmentioning

confidence: 99%

“…Biopyrrins are end products of the oxidation reaction of the suicide antioxidant bilirubin with reactive oxygen species (ROS) ( Figure 1) [12]. An increase in bilirubin consumption owing to oxidative stress is reflected through an increased level of urinary biopyrrins (UBP).…”

Section: Introductionmentioning

confidence: 99%

Reference urinary biopyrrin level and physiological variation in healthy young adults: relation of stress by learning

Tada

Shiota

Hayashi³

et al. 2020

Heliyon

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“…Finally, the reported antioxidant activities of M. longifolia (Murad et al, 2016) could be one of the possible ways by which it alleviates experimentally induced angina. The oxidative stress plays a very important role in the cardiac injury after ischemia-reperfusion (Yamamoto, Nishimori, Fukutomi, Yamaguchi, & Orihashi, 2017).…”

Section: Discussionmentioning

confidence: 99%

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

2018

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Angina occurs due to imbalance between heart oxygen demand and supply and is associated with serious morbidity and mortality. Here, the possible antianginal effect of Mentha longifolia extract was studied in experimental model of angina. Aerial parts of M. longifolia were extracted, standardized, and given to rats three days before angina. Heart hemodynamics and conductivity were recorded by microtip catheter and surface electrodes. M. longifolia extract significantly alleviated the sustained decline in cardiac contractility after vasopressin exposure. However, M. longifolia did not affect the impaired cardiac dilation after vasopressin. Heart rate was significantly decreased after vasopressin exposure in rats treated with M. longifolia compared with untreated animals. In addition, M. longifolia produced more increase in systolic and diastolic durations after vasopressin exposure compared with untreated animals. Moreover, the plant extract alleviated the ST height changes during vasopressin injection. M. longifolia extract alleviates impaired cardiac function associated with angina through decreasing heart work. Practical applications The present study is the first to study the effect of M. longifolia in an experimental model of angina. M. longifolia alleviated the impaired cardiac contractility associated with angina exposure. The antianginal effect of M. longifolia could be through reducing cardiac load. This can be concluded from the decrease in heart rate and the systolic and diastolic cycles elongation after exposure to vasopressin in animals pretreated with M. longifolia. This helps in reducing the associated cardiac ischemia upon exposure to vasopressin as indicated by ST change. This could provide new directions in the management of the serious angina disease.

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“…The explanation for these findings is likely to be the increased consumption of bilirubin. The oxidized metabolites of bilirubin in urine were designated as biopyrrins and reported to be increased in pathological oxidative stress-related conditions [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Relationship between serum bilirubin levels, urinary biopyrrin levels, and retinopathy in patients with diabetes

et al. 2021

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Objective Previous reports have indicated that serum bilirubin levels may be associated with diabetic retinopathy. However, the detailed mechanism is not fully understood. In this study, we evaluated the relationship between the severity of diabetic retinopathy and various factors including bilirubin levels and factors influencing bilirubin metabolism. Methods The study participants consisted of 94 consecutive patients with diabetes mellitus admitted to Kyushu University Hospital from April 2011 to July 2012. The patients were classified into three groups: no retinopathy (NDR), simple retinopathy (SDR), and pre-proliferative or proliferative retinopathy (PDR). The relationship between the severity of retinopathy and various factors was evaluated using univariate and logistic regression analyses. In addition, multivariate regression analysis was performed to evaluate the significant determinants for bilirubin levels. Results In univariate analysis, a significant difference was found among NDR, SDR and PDR in bilirubin levels, duration of diabetes, systolic blood pressure, and macroalbuminuria. Logistic regression analysis showed that PDR was significantly associated with bilirubin levels, duration of diabetes, and systolic blood pressure (OR 0.737, 95% CI 0.570–0.952, P = 0.012; OR 1.085, 95% CI 1.024–1.149, P = 0.006; OR 1.036, 95% CI 1.011–1.062, P = 0.005, respectively). In turn, multivariate regression analysis showed that bilirubin levels were negatively associated with high-sensitivity C-reactive protein levels and PDR, but positively correlated with urinary biopyrrin levels, oxidized metabolites of bilirubin. Conclusion PDR was negatively associated with bilirubin levels. This negative association may be due to a decreased production of bilirubin rather than its increased consumption considering the positive association between bilirubin and biopyrrin levels.

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Dynamics of Oxidative Stress Evoked by Myocardial Ischemia Reperfusion After Off-Pump Coronary Artery Bypass Grafting Elucidated by Bilirubin Oxidation

Cited by 14 publications

References 34 publications

Reference urinary biopyrrin level and physiological variation in healthy young adults: relation of stress by learning

Reference urinary biopyrrin level and physiological variation in healthy young adults: relation of stress by learning

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

Relationship between serum bilirubin levels, urinary biopyrrin levels, and retinopathy in patients with diabetes

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