Dynamics of Peripheral Blood Lymphocyte Subpopulations in the Acute and Subacute Phase of Legionnaires’ Disease

Jager, Cornelis P.C. de; Gemen, Eugenie F.A.; Leuvenink, J.; Hilbink, Mirrian; Laheij, R.J.F.; Poll, Tom van der; Wever, Peter C.

doi:10.1371/journal.pone.0062265

Cited by 11 publications

(9 citation statements)

References 42 publications

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“…21 De Jager and colleagues in the years 2006-2007 in the Netherlands in a case -control study of patients with severe community-acquired pneumonia found 8 patients with L. pneumophila٫4 patients (50%) were smoking. 19 Smoking rates in these studies were higher than our study. This may be due to: (1) lower consumption of cigarettes by our patients (2) we have not defined smoking alike.…”

Section: Discussioncontrasting

confidence: 72%

“…18 In other studies age was high and the majority was men. 19,20 In the present study our patients were younger than patients in other studies, one of the reasons could be the difference in life expectancy in different countries on the other hand may be at a lower incidence of pneumonia in our region that these cases need to be investigated further. In our study a little percentage of patients (3.6%) had positive urinary antigen.…”

Section: Discussionmentioning

confidence: 50%

“…De Jager and colleagues in the Netherlands in 2006-2007 in reviewing the case-control study on patients who had been hospitalized community-acquired Legionella, an average of lymphocytes in initial hospitalization was low (less than 800) and introduced as a L. pneumophila prognostic factor. 19 In this regard, more studies did not compare.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of detecting Legionella Pneumophilla with urinary antigen test in teaching hospitals

Fazeli

Mohammadi

Mousavian

et al. 2020

Clinical Epidemiology and Global Health

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Introduction: Pneumonia is one of the most common causes of mortality among respiratory diseases, Legionella pneumophila (L.pneumophila) is an important cause of pneumonia in the world. Despite the evidences of favorable epidemiological conditions and the presence of the pathogen in Ahvaz, this disease has not been investigated properly. Objective: The aim of this research project was to determine the frequency of L.pneumophila with urinary antigen test in hospitalized patients with Community-Acquired Pneumonia (CAP) in need and non-need intensive care in Ahvaz. Materials and methods: In this case-control study, two groups of 70 patients with CAP need Intensive-Care Unit (ICU) as cases, and non-need ICU as controls who were hospitalized in teaching hospitals of Ahvaz were selected and tested for urinary antigen by a commercial kit (Legionella Kit, 2016٫ Belgium). Data were analyzed using SPSS 15 software by descriptive statistics. Results: According to the data analysis, 140 patients, 5 patients (3.6%) were positive for the Legionella urinary antigen٫ 3 (4.3%) were in case and 2 (2.9%) in control group. Although cases in compare with controls were more likely to be smokers, having serum sodium less than 130(meq/lit) and less than 1500(cell/ml) lymphocytes in cell blood count, but statistically were not significant. In the region of study, L.pneumophila can cause respiratory infection but is an uncommon cause of pneumonia in hospitalized patients. Conclusion: This disease primarily involves smokers and people with immunodeficiency; especially those with low lymphocyte early in admission. Therefore, in patients with a history of smoking and severe pneumonia requiring hospitalization in ICU, Legionella should be kept in mind.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 50%

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Comparison of detecting Legionella Pneumophilla with urinary antigen test in teaching hospitals

Fazeli

Mohammadi

Mousavian

et al. 2020

Clinical Epidemiology and Global Health

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“…Indeed, 82.6% of the patients in our study cohort suffered from chronic comorbidity. In addition, another partial explanation for the shorter telomeres upon PICU admission could be the acute rise in the fraction of neutrophils within the white blood cell population of critically ill patients, as neutrophils have shorter telomeres than lymphocytes [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition

Verstraete¹,

Vanhorebeek²,

Puffelen

et al. 2018

Crit Care

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BackgroundChildren who have suffered from critical illnesses that required treatment in a paediatric intensive care unit (PICU) have long-term physical and neurodevelopmental impairments. The mechanisms underlying this legacy remain largely unknown. In patients suffering from chronic diseases hallmarked by inflammation and oxidative stress, poor long-term outcome has been associated with shorter telomeres. Shortened telomeres have also been reported to result from excessive food consumption and/or unhealthy nutrition. We investigated whether critically ill children admitted to the PICU have shorter-than-normal telomeres, and whether early parenteral nutrition (PN) independently affects telomere length when adjusting for known determinants of telomere length.MethodsTelomere length was quantified in leukocyte DNA from 342 healthy children and from 1148 patients who had been enrolled in the multicenter, randomised controlled trial (RCT), PEPaNIC. These patients were randomly allocated to initiation of PN within 24 h (early PN) or to withholding PN for one week in PICU (late PN). The impact of early PN versus late PN on the change in telomere length from the first to last PICU-day was investigated with multivariable linear regression analyses.ResultsLeukocyte telomeres were 6% shorter than normal upon PICU admission (median 1.625 (IQR 1.446–1.825) telomere/single-copy-gene ratio (T/S) units vs. 1.727 (1.547–1.915) T/S-units in healthy children (P < 0.0001)). Adjusted for potential baseline determinants and leukocyte composition, early PN was associated with telomere shortening during PICU stay as compared with late PN (estimate early versus late PN –0.021 T/S-units, 95% CI −0.038; 0.004, P = 0.01). Other independent determinants of telomere length identified in this model were age, gender, baseline telomere length and fraction of neutrophils in the sample from which the DNA was extracted. Telomere shortening with early PN was independent of post-randomisation factors affected by early PN, including longer length of PICU stay, larger amounts of insulin and higher risk of infection.ConclusionsShorter than normal leukocyte telomeres are present in critically ill children admitted to the PICU. Early initiation of PN further shortened telomeres, an effect that was independent of other determinants. Whether such telomere-shortening predisposes to long-term consequences of paediatric critical illness should be further investigated in a prospective follow-up study.Trial registrationClinicalTrials.gov, NCT01536275. Registered on 16 February 2012.Electronic supplementary materialThe online version of this article (10.1186/s13054-018-1972-6) contains supplementary material, which is available to authorized users.

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“…has concluded that absolute lymphocytopenia is associated with patients having severe Legionnaires' disease. [ 10 ] In addition, Fox et al . used lymphocytopenia as an early marker in patients with H1N1 flu infections.…”

Section: Discussionmentioning

confidence: 99%

Lymphocytopenia may be a new indicator for infected obstructed kidneys secondary to urinary stone disease

2015

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Objective:Infected obstructed kidney (IOK) is a urological emergency. We wanted to look at the role of serum inflammatory markers in these patients.Materials and Methods:Patients with IOK requiring percutaneous nephrostomy (PCN) at our university hospital were identified, and data were collected on lymphocyte count, C-reactive protein (CRP) and microbiology results.Results:Thirty-nine patients had PCN for IOK. Lymphocytopenia was seen in two-thirds of these patients. Severe lymphocytopenia was associated with a significant rise in CRP in all cases and following PCN, lymphocytopenia improved in the majority of cases.Conclusions:Lymphocytopenia seems to be associated with the severity of infection and could be a surrogate marker on its own or in conjunction with CRP for initial diagnosis and monitoring response to treatment in patients with IOKs.

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Dynamics of Peripheral Blood Lymphocyte Subpopulations in the Acute and Subacute Phase of Legionnaires’ Disease

Cited by 11 publications

References 42 publications

Comparison of detecting Legionella Pneumophilla with urinary antigen test in teaching hospitals

Comparison of detecting Legionella Pneumophilla with urinary antigen test in teaching hospitals

Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition

Lymphocytopenia may be a new indicator for infected obstructed kidneys secondary to urinary stone disease

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