Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis

Custódio, Jeniffer Michelline de Oliveira; Enokida, Iasmim Mayumi; Gonçalves, Daniel A.; Oliveira, Sandra Maria do Valle Leone de; Venturini, James; Carvalho, Lídia Raquel de; Mendes, Rinaldo Pôncio; Paniago, Anamaria Mello Miranda

doi:10.1371/journal.pone.0226609

Cited by 5 publications

(6 citation statements)

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“…Additionally, severe cases were associated with higher ferritin levels, probably because of the production of IL-6 caused by fungal infection. A previous study by our group reported similar results [14].…”

Section: Discussionsupporting

confidence: 86%

“…The host-parasite interaction and consequent inflammatory response lead to changes in iron metabolism dynamics. These changes can be observed in some patients with PCM [14], which is a chronic systemic inflammatory disease requiring long-term treatment. Understanding the frequency and intensity of iron metabolism disturbances in patients with chronic PCM will help improve therapeutic management.…”

Section: Introductionmentioning

confidence: 99%

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Iron metabolism disorders of patients with chronic paracoccidioidomycosis

Brito

Siqueira

Venturini

et al. 2023

Preprint

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Paracoccidioidomycosis (PCM) is caused by Paracoccidioides spp.; during infection, some host mechanisms limit the availability of iron, thereby reducing its reproduction. However, Paracoccidioides spp. can evade the immune defense and, even under limited iron conditions, use this mineral for growth and dissemination. This study evaluated the iron metabolism of 39 patients who were diagnosed with chronic PCM between 2013 and 2021. The forms of iron before treatment and at the time of clinical cure were evaluated based on the following: serum ferritin levels (storage iron); total iron-binding capacity (TIBC) and transferrin saturation (TSAT) level (transport iron); red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), and soluble transferrin receptor (sTfR) levels; and sTfR/log ferritin ratio (functional iron). The mean age of the patients was 54.5 years (±6.7 years). Most patients were men (97.4%), rural workers (92.1%), and smokers (84.6%); most had moderate disease severity (66.7%). Before treatment, the median values of all evaluated parameters were within or just slightly outside the normal range of values. However, it is possible to infer that PCM interferes with functional and storage iron because improvements in these parameters after treatment as well as associations with disease severity were observed. Furthermore, moderate correlations were observed between C-reactive protein and the Hb (r=-0.500; p=0.002), RBC (r=-0.461; p=0.005), HCT (r=-0.514; p=0.001), and iron levels (r=-0.491; p=0.002). PCM interferes with iron metabolism by transforming functional iron to storage iron, as revealed by anemia, low iron levels with normal TSAT levels, normal TIBC, normal sTfR levels, normal sTfR/log ferritin ratios, and normal or slightly increased ferritin levels. PCM can lead to anemia of inflammation, which can be differentiated from iron deficiency anemia by a careful investigation of the iron form parameters.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Iron metabolism disorders of patients with chronic paracoccidioidomycosis

Brito

Siqueira

Venturini

et al. 2023

Preprint

Self Cite

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“…These findings are more commonly reported in the acute/subacute form of the disease. Few studies on blood cells in chronic PCM have been described, showing changes in the number of erythrocytes and the concentration of hemoglobin [8], as well as in the subpopulations of monocytes and lymphocytes, in untreated patients [9][10][11]. The complete blood count is a simple test performed routinely in most clinics and is important in the clinical management of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Analysis and Interpretation of Automated Blood Count in the Treatment of Chronic Paracoccidioidomycosis

Brito,

França,

Siqueira

et al. 2024

Preprint

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The blood count is crucial for assessing bone marrow's cell production and differentiation during infections, gauging disease severity, and monitoring therapeutic responses. The profile of blood count in chronic form of paracoccidioidomycosis (PCM) has been insufficiently explored. To better understand the changes in hematological cells in different stages of the PCM chronic form, we evaluated the blood count, including immature blood cells in automated equipment, before and during the treatment follow-up of 62 chronic PCM patients. Predominantly male (96.8%) with an average age of 54.3 (SD 6.9) years, participants exhibited pre-treatment conditions such as anemia (45.2%), monocytosis (38.7%), and leukocytosis (17.7%) which became less frequent after clinical cure. Anemia was more prevalent in severe cases. Notably, hemoglobin and reticulocyte hemoglobin content increased, while leukocytes, monocytes, neutrophils, immature granulocytes, and platelets decreased. Chronic PCM induced manageable hematological abnormalities, mainly in the red blood series. Monocytosis, indicating monocytes' role in PCM's immune response, was frequent. Post-treatment, especially after achieving clinical cure, significant improvements were observed in various hematological indices, including immature granulocytes and reticulocyte hemoglobin content, underscoring the impact of infection on these parameters.

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“…Few studies on blood cells in chronic PCM have been described, showing changes in the number of erythrocytes and the concentration of hemoglobin [14], as well as in the subpopulations of monocytes and lymphocytes, in untreated patients [15][16][17]. The complete blood count is a simple test performed routinely in most clinics and is important in the clinical management of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Analysis and Interpretation of Automated Blood Count in the Treatment of Chronic Paracoccidioidomycosis

Brito,

França,

Siqueira

et al. 2024

JoF

Self Cite

View full text Add to dashboard Cite

Blood count is crucial for assessing bone marrow’s cell production and differentiation during infections, gaging disease severity, and monitoring therapeutic responses. The profile of blood count in chronic forms of paracoccidioidomycosis (PCM) has been insufficiently explored. To better understand the changes in hematological cells in different stages of the PCM chronic form, we evaluated the blood count, including immature blood cells in automated equipment, before and during the treatment follow-up of 62 chronic PCM patients. Predominantly male (96.8%) with an average age of 54.3 (standard deviation SD 6.9) years, participants exhibited pre-treatment conditions such as anemia (45.2%), monocytosis (38.7%), and leukocytosis (17.7%), which became less frequent after clinical cure. Anemia was more prevalent in severe cases. Notably, hemoglobin and reticulocyte hemoglobin content increased, while leukocytes, monocytes, neutrophils, immature granulocytes, and platelets decreased. Chronic PCM induced manageable hematological abnormalities, mainly in the red blood series. Monocytosis, indicating monocytes’ role in PCM’s immune response, was frequent. Post-treatment, especially after achieving clinical cure, significant improvements were observed in various hematological indices, including immature granulocytes and reticulocyte hemoglobin content, underscoring the impact of infection on these parameters.

show abstract

Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis

Cited by 5 publications

References 50 publications

Iron metabolism disorders of patients with chronic paracoccidioidomycosis

Iron metabolism disorders of patients with chronic paracoccidioidomycosis

Analysis and Interpretation of Automated Blood Count in the Treatment of Chronic Paracoccidioidomycosis

Analysis and Interpretation of Automated Blood Count in the Treatment of Chronic Paracoccidioidomycosis

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