Dynamics of spinal cord compression with different patterns of thoracolumbar burst fractures: Numerical simulations using finite element modelling

Diotalevi, Lucien; Bailly, Nicolas; Wagnac, Éric; Mac-Thiong, Jean-Marc; Goulet, Julien; Petit, Yvan

doi:10.1016/j.clinbiomech.2019.12.023

Cited by 22 publications

(14 citation statements)

References 36 publications

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“…A study published in 2020 proposed a thorough FEM of the spine to better reproduce SCI resulting from vertebral fractures [31]. In particular, FEM was used to examine the strain tolerated by the spinal cord through various parameters, as well as to analyze the potential involvement of the posterior vertebral body wall.…”

Section: Fracturementioning

confidence: 99%

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Finite Element Method for the Evaluation of the Human Spine: A Literature Overview

Naoum

Vasiliadis

Koutserimpas

et al. 2021

JFB

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The finite element method (FEM) represents a computer simulation method, originally used in civil engineering, which dates back to the early 1940s. Applications of FEM have also been used in numerous medical areas and in orthopedic surgery. Computing technology has improved over the years and as a result, more complex problems, such as those involving the spine, can be analyzed. The spine is a complex anatomical structure that maintains the erect posture and supports considerable loads. Applications of FEM in the spine have contributed to the understanding of bone biomechanics, both in healthy and abnormal conditions, such as scoliosis, fractures (trauma), degenerative disc disease and osteoporosis. However, since FEM is only a digital simulation of the real condition, it will never exactly simulate in vivo results. In particular, when it concerns biomechanics, there are many features that are difficult to represent in a FEM. More FEM studies and spine research are required in order to examine interpersonal spine stiffness, young spine biomechanics and model accuracy. In the future, patient-specific models will be used for better patient evaluations as well as for better pre- and inter-operative planning.

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Section: Fracturementioning

confidence: 99%

“…The features of ley fracture patterns associated with SCI were recognized. These can be used for the better comprehension of injuries from the biomechanical loading of the spinal cord during trauma [31].…”

Section: Fracturementioning

confidence: 99%

Finite Element Method for the Evaluation of the Human Spine: A Literature Overview

Naoum

Vasiliadis

Koutserimpas

et al. 2021

JFB

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“…The FE model also includes a spinal cord model previously described by Fradet et al (2014), Taso et al (2015 and Diotalevi et al (2020). It is composed of white and grey matter, denticulate ligaments, pia mater and dura mater (Fig.…”

Section: Finite Element Modelling Of the Cervical Spinementioning

confidence: 99%

Numerical investigation of the relative effect of disc bulging and ligamentum flavum hypertrophy on the mechanism of central cord syndrome

Bailly

Diotalevi

Beauséjour

et al. 2020

Clinical Biomechanics

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Background:The pathogenesis of the central cord syndrome is still unclear. While there is a consensus on hyperextension as the main traumatic mechanism leading to this condition, there is yet to be consensus in studies regarding the pathological features of the spine (intervertebral disc bulging or ligamentum flavum hypertrophy) that could contribute to clinical manifestations. Methods:A comprehensive finite element model of the cervical spine segment and spinal cord was used to simulate high-speed hyperextension. Four stenotic cases were modelled to study the effect of ligamentum flavum hypertrophy and intervertebral disc bulging on the von Mises stress and strain.Findings: During hyperextension, the downward displacement of the ligamentum flavum and a reduction of the spinal canal diameter (up to 17%) led to a dynamic compression of the cord.Ligamentum flavum hypertrophy was associated with stress and strain (peak of 0.011 Mpa and 0.24, respectively) in the lateral corticospinal tracts, which is consistent with the histologic pattern of the central cord syndrome. Linear intervertebral disc bulging alone led to a higher stress in the anterior and posterior funiculi (peak 0.029 Mpa). Combined with hypertrophic ligamentum flavum, it further increased the stress and strain in the corticospinal tracts and in the posterior horn (peak of 0.023 Mpa and 0.35, respectively). Interpretation:The stenotic typology and geometry greatly influence stress and strain distribution resulting from hyperextension. Ligamentum flavum hypertrophy is a main feature leading to central cord syndrome.

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“…Although some studies have proposed non-linear material models (Jannesar et al, 2020), the associated models typically involve very small mesh sizes (e.g., <0.5 mm) that are prohibitive for current state-of-the-art HBM (Schwartz et al, 2015;Kimpara et al, 2016;Östh et al, 2017). In contrast, models utilizing coarse meshes often incorporate simplified elastic material properties (Greaves et al, 2008) and have not been evaluated in terms of model biofidelity for impact scenarios (Kimpara et al, 2006;Henao et al, 2016, Henao et al, 2018Diotalevi et al, 2020). Importantly, the existing models also lack hierarchical assessment and robust validation that are needed prior to integration in HBM.…”

Section: Introductionmentioning

confidence: 99%

A Hyper-Viscoelastic Continuum-Level Finite Element Model of the Spinal Cord Assessed for Transverse Indentation and Impact Loading

Rycman

McLachlin

Cronin

2021

Front. Bioeng. Biotechnol.

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Finite Element (FE) modelling of spinal cord response to impact can provide unique insights into the neural tissue response and injury risk potential. Yet, contemporary human body models (HBMs) used to examine injury risk and prevention across a wide range of impact scenarios often lack detailed integration of the spinal cord and surrounding tissues. The integration of a spinal cord in contemporary HBMs has been limited by the need for a continuum-level model owing to the relatively large element size required to be compatible with HBM, and the requirement for model development based on published material properties and validation using relevant non-linear material data. The goals of this study were to develop and assess non-linear material model parameters for the spinal cord parenchyma and pia mater, and incorporate these models into a continuum-level model of the spinal cord with a mesh size conducive to integration in HBM. First, hyper-viscoelastic material properties based on tissue-level mechanical test data for the spinal cord and hyperelastic material properties for the pia mater were determined. Secondly, the constitutive models were integrated in a spinal cord segment FE model validated against independent experimental data representing transverse compression of the spinal cord-pia mater complex (SCP) under quasi-static indentation and dynamic impact loading. The constitutive model parameters were fit to a quasi-linear viscoelastic model with an Ogden hyperelastic function, and then verified using single element test cases corresponding to the experimental strain rates for the spinal cord (0.32–77.22 s−1) and pia mater (0.05 s−1). Validation of the spinal cord model was then performed by re-creating, in an explicit FE code, two independent ex-vivo experimental setups: 1) transverse indentation of a porcine spinal cord-pia mater complex and 2) dynamic transverse impact of a bovine SCP. The indentation model accurately matched the experimental results up to 60% compression of the SCP, while the impact model predicted the loading phase and the maximum deformation (within 7%) of the SCP experimental data. This study quantified the important biomechanical contribution of the pia mater tissue during spinal cord deformation. The validated material models established in this study can be implemented in computational HBM.

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Dynamics of spinal cord compression with different patterns of thoracolumbar burst fractures: Numerical simulations using finite element modelling

Cited by 22 publications

References 36 publications

Finite Element Method for the Evaluation of the Human Spine: A Literature Overview

Finite Element Method for the Evaluation of the Human Spine: A Literature Overview

Numerical investigation of the relative effect of disc bulging and ligamentum flavum hypertrophy on the mechanism of central cord syndrome

A Hyper-Viscoelastic Continuum-Level Finite Element Model of the Spinal Cord Assessed for Transverse Indentation and Impact Loading

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