Dynamics of the cognitive sphere indicators and neurotrophic factors in the course of balneotherapy of dyscirculatory encephalopathy

Rationale: considering the high frequency of occurrence of mental disorders in the general medical network, as well as due to the not always sufficient success of biological therapy of mental diseases and not uncommon poor tolerability, it is of interest to consider non-drug methods of spa treatment of these conditions. The analysis of the literature has shown that until recently, regarding non-drug methods of correction of mental disorders, as a rule, only studies on individual methods are given without considering the entire range of possible procedures that can potentially be used for therapy, or the information provided is very formal.The purpose of this work was to consider non-drug methods of treatment of mental disorders used in the conditions of the sanatorium-resort industry and, according to modern principles of evidence-based medicine, to assess the available evidence of their effectiveness and safety; as well as new prospects for the use of well-known techniques. Materials and methods: to search for possible non-drug methods of mental disorders correction and their mechanism of action, modern guidelines for balneology treatment and medical rehabilitation, electronic databases of the RSCI and MedLine were studied, the latter also searched for publications of studies confirming the effectiveness of the studied methods, which was carried out by keywords (names of relevant methods and mental dysfunctions, such as anxiety, depression, cognitive disorders, adaptation disorders, stress states, psychosomatics); the levels of evidence of effectiveness and safety were evaluated according to the National Standard of the Russian Federation GOST R 56034-2014.As a result of the work carried out, the vast majority of methods of correction of mental disorders used in the sanatorium-resort area are covered. The information presented concerns not only stress-related disorders traditionally related to borderline psychiatry, but also diseases of a more severe register and cognitive impairments; depending on the etiology and clinic of mental illness, the described techniques may be applicable as the main or additional treatment methods; some of them have a high evidence-based level of effectiveness, the other seems promising for further study in terms of therapy of individual mental disorders.Conclusion: the information provided may be of interest both for the scientific and practical fields of psychiatry, when solving problems aimed at improving the effectiveness of treatment and improving the quality of life of patients with mental illnesses.

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Non-Medicamentous Spa Treatment of Mental Disorders

Kuzyukova

Rachin

Кончугова

2022

Psychiatry

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The study of relationships between clinical syndromes and gene polymorphisms of ACE and AT2R1 genes in patients with chronic vascular encephalopathy

Duve

2023

UVP

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This article presents the results of the study of relationships between clinical presentation and polymorphism of the ACE and AT2R1 genes in patients with chronic vascular encephalopathy (CVE). The 145 patients with chronic vascular encephalopathy (CVE) were examined in order to analyze the clinical presentation of the disease. The molecular genetic research was performed in 18 patients. After the complete clinical and neurological examination, such frequency of the syndromes was found: cephalalgic (70.34 %), extrapyramidal (60.00 %), vestibular (61.38 %), asthenic (53.79 %) syndromes, and syndrome of cognitive disorders (66.21 %). When assessing the dependence of the clinical syndromes most often found in patients with CVE on the I/D polymorphism of the ACE gene, it was established that 90.91 % of patients with cephalalgic syndrome, 81.82 % of patients with asthenic syndrome, and 90.91 % of patients with extrapyramidal syndrome are carriers of the D/D genotype. In contrast, all patients with the absence of cephalalgic, extrapyramidal, and asthenic syndromes had the I/I ACE gene genotype. No significant correlations were found between the presence/absence of clinical syndromes and the frequency distribution of genotypes and alleles of the A1166C polymorphic variant of the AT2R1 gene in patients with CVE. Key words: encephalopathy, ACE gene polymorphism, AT2R1 gene polymorphism, vascular encephalopathy, chronic brain ischemia

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Dynamics of the cognitive sphere indicators and neurotrophic factors in the course of balneotherapy of dyscirculatory encephalopathy

Cited by 2 publications

References 10 publications

Non-Medicamentous Spa Treatment of Mental Disorders

Non-Medicamentous Spa Treatment of Mental Disorders

The study of relationships between clinical syndromes and gene polymorphisms of ACE and AT2R1 genes in patients with chronic vascular encephalopathy

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