Abstract.Observations suggest that during the last decades the Greenland Ice Sheet (GrIS) has experienced a gradually accelerating mass loss, in part due to the observed speedup of several of Greenland's marine-terminating glaciers. Recent studies directly attribute this to warming North Atlantic temperatures, which have triggered melting of the outlet glaciers of the GrIS, grounding-line retreat and enhanced ice discharge into the ocean, contributing to an acceleration of sea-level rise. Reconstructions suggest that the influence of the ocean has been of primary importance in the past as well. This was the case not only in interglacial periods, when warmer climates led to a rapid retreat of the GrIS to land above sea level, but also in glacial periods, when the GrIS expanded as far as the continental shelf break and was thus more directly exposed to oceanic changes. However, the GrIS response to palaeo-oceanic variations has yet to be investigated in detail from a mechanistic modelling perspective. In this work, the evolution of the GrIS over the past two glacial cycles is studied using a three-dimensional hybrid ice-sheetshelf model. We assess the effect of the variation of oceanic temperatures on the GrIS evolution on glacial-interglacial timescales through changes in submarine melting. The results show a very high sensitivity of the GrIS to changing oceanic conditions. Oceanic forcing is found to be a primary driver of GrIS expansion in glacial times and of retreat in interglacial periods. If switched off, palaeo-atmospheric variations alone are not able to yield a reliable glacial configuration of the GrIS. This work therefore suggests that considering the ocean as an active forcing should become standard practice in palaeo-ice-sheet modelling.