Dynamics of the Response to Variations in Dietary Choline Content in Rats

Guseva, M. V.; Kamenskiy, A. A.; Gusev, Vladislav

doi:10.1007/s10517-012-1861-y

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Second, dietary choline may offset the drop in systemic choline after surgery ( Ulus et al, 1998 ). Third, dietary choline supplementation may be acting via increases in the number of anatomically localized receptors and agonists that are difficult to detect systemically or via whole-brain assessment ( Morley et al, 1977 ; Coutcher et al, 1992 ; Guseva et al, 2012 ). Future work is required to pinpoint the specific mechanistic action, or combination of actions, of dietary choline supplementation.…”

Section: Discussionmentioning

confidence: 99%

Dietary Choline Protects Against Cognitive Decline After Surgery in Mice

Maurer

Kong

Terrando

et al. 2021

Front. Cell. Neurosci.

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Perioperative neurocognitive disorders (PNDs) are a common complication following procedures such as orthopedic surgery. Using a mouse model of tibial fracture and repair surgery, we have previously shown an increase in neuroinflammation and hippocampal-dependent cognitive deficits. These changes were ameliorated with the addition of a cholinergic agonist. Here, we sought to examine the effects of a high-choline diet for 3 weeks prior to tibial fracture surgery. We evaluated memory using novel object recognition (NOR) as well as young neurons and glial cell morphology at 1 day and 2 weeks post-surgery. At both time points, tibial fracture impaired NOR performance, and dietary choline rescued these impairments. Astrocytic density and hilar granule cells increased 1 day after tibial fracture, and these increases were partially blunted by dietary choline. An increase in young neurons in the subgranular zone of the dentate gyrus was found 2 weeks after tibial fracture. This increase was partially blunted by choline supplementation. This suggests that shortly after tibial fracture, hippocampal reorganization is a possible mechanism for acute impaired memory. These findings together suggest that non-pharmaceutical approaches, such as pre-surgical dietary intervention with choline, may be able to prevent PNDs.

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Section: Discussionmentioning

confidence: 99%

Dietary Choline Protects Against Cognitive Decline After Surgery in Mice

Maurer

Kong

Terrando

et al. 2021

Front. Cell. Neurosci.

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Optimization of Choline Administration Regimen for Correction of Cognitive Functions in Rats after Brain Injury

2013

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Choline diet promotes improvement of the brain cognitive functions in rats with moderate-to-severe traumatic brain injury. In previous studies, the rats received choline being standard (0.2%) or choline-supplemented (2%) diet for 2 weeks prior to and 2 weeks after experimental brain injury. To the end of the experiments (in 4 weeks), the post-traumatic disturbances in the cognitive functions were observed in both groups, although they were less pronounced than in the rats kept on the choline-supplemented diet. Based on original mathematical model, this paper proposes a method to calculate the most efficient use of choline to correct the brain cognitive functions. In addition to evaluating the cognitive functions, the study assessed expression of α7 nicotinic acetylcholine receptors, the amount of consumed food and water, and the dynamics of body weight.

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Dynamics of the Response to Variations in Dietary Choline Content in Rats

Cited by 2 publications

References 9 publications

Dietary Choline Protects Against Cognitive Decline After Surgery in Mice

Dietary Choline Protects Against Cognitive Decline After Surgery in Mice

Optimization of Choline Administration Regimen for Correction of Cognitive Functions in Rats after Brain Injury

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