Dynamics of the seizure states caused by the action of ligands of the inhibitory transmitter system, as a consequence of evolution of stochastic neuronal populations

Seizure effects resulting from modification of GABAA-dependent inhibition: A computer simulation study

“…In general, the proposed computer model was similar to that we described earlier [3]. Our approach was based on the use of chamber models to study the kinetic proMechnikov State University, Odessa, Ukraine.…”

“…Thus, the dynamics of a BC-caused epileptic attack are practically identical to the dynamics described above and observed in the mathematical model of a neuronal network. This fact is indicative of the adequacy of such a model for further analysis of the processes underlying the functioning of the GABA TS under the influence of modulators of the given system (in particular, benzodiazepines and barbiturates), which are known to suppress paroxysmal states developing in the CNS [2,3].…”

“…Electrophysiological experiments were carried out on Wistar rats. The sequence of formation of status epilepticus under the influence of BC and BD is described earlier [3]. As an integral index characterizing the brain electrical activity, we consider integral deviation of the potential from an averaged interpulse interval value (W,), i.e., a standard deviation of the process [5].…”