Dynamics of ultrastructural transformations of paired biological membranes in the nervous system

Os, Sotnikov; Paramonova, N. M.; Арчакова, Л. И.

doi:10.1134/s1990747810051046

Cited by 1 publication

(5 citation statements)

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“…A). As a result, the neuroglial border becomes perforated, as observed at the axon/axon or axon/glia borders (Peracchia, ; Sotnikov and Paramonova, ; Sotnikov et al, ). However, such perforations in the crayfish stretch receptor, which could form the syncytial interconnections, are sealed by the diffuse material (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Formation of tight junctions between paired membranes has been suggested to precede PM fusion, destabilization, formation of vesicles, and perforations (Samosudova et al, ; Sotnikov and Paramonova, ; Sotnikov et al, ). The presence of unsealed PM perforations between crayfish axons and glial cells (Peracchia, ; Sotnikov et al, ) and between neurons of crayfish, mollusks, and mammals (Sotnikov et al, ; Sotnikov and Paramonova, ) has been previously reported.…”

Section: Discussionmentioning

confidence: 99%

“…They can result from local and temporal membrane instabilities induced by local tension. Such a situation can emerge in places of strong PM curvature (PM invaginations) or near the pentalaminar regions of tightly contacting membranes (Sotnikov et al, ). In the last case, the failure in formation of true gap junctions between approaching membranes can lead to mixing of membrane lipids, followed by vesicle formation.…”

Section: Discussionmentioning

confidence: 99%

“…Such pores are unstable; smaller ones are closed and form a lipid bilayer, whereas larger pores disrupt the membrane. Fluctuations in acyl chain conformations in the membrane regulate the defects that nucleate rupture pores (Evans and Rawicz, ; Sotnikov et al, ). PM disorganization, including membrane fusion and formation of the diffuse area containing vesicles, is involved in formation of double‐membrane vesicles (DMV; Figs.…”

Section: Discussionmentioning

confidence: 99%

“…For these functions, neurons and glial cells exchange ions, metabolites, neurotransmitters, and neurotrophic factors (Verkhratsky, ; Verkhratsky and Butt, ). Adjacent neuronal and glial membranes are referred to as paired (Sotnikov and Paramonova, ; Sotnikov et al, ). They are separated by a narrow layer of the extracellular medium.…”

mentioning

confidence: 99%

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The paired neuroglial and interglial membranes in the crayfish stretch receptor and their local disorganization

Федоренко

Neginskaya

Fedorenko

et al. 2014

J of Neuroscience Research

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The paired neuronal and glial membranes, or interglial membranes, which are separated by the narrow layer of the extracellular medium, are involved in intercellular communications. In the crayfish stretch receptor, the paired neuroglial membranes contain thin protein bridges (septate junctions) that maintain the intermembrane gap. In some places the paired membranes are locally disorganized. In the altered regions, they comprise the diffuse material in which a few 10-15 nm vesicles are embedded. The development of these defects can lead to formation of 20-30 nm vesicles and perforations in the paired membranes. The presence of such holes can, in principle, disturb ionic gradients and neuronal activity. However, a free passage between contacting neurons and glia is prevented by the diffuse proteolipid material (the product of the membrane disorganization) that seals perforations. As a result, the neuroglial border does not lose its integrity and impermeability for ions so that the sensory neurons save the capability for prolonged regular firing. Unlike the neuroglial border, some perforations in the paired glia-glial membranes are not sealed. This can create the interglial syncytial connections providing the shortcut pathway for transport of ions and metabolites across the glial layers in the crayfish stretch receptor.

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Section: Resultsmentioning

confidence: 99%