Dynamik des normalen und pathologischen Haarwachstums

A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

“…Based on basic histological and ultrastructural studies on human and rodent CIA (Braun-Falco, 1966;Herzberg, 1966), we have summarized basic as well as more advanced auxiliary criteria to define the distinct stages of the dystrophic anagen and the dystrophic catagen pathway (Figs 3 and 4) which are widely applicable to different mouse strains and mutants. In essence, this classification guide can also be utilized for staging the hair follicles of other hair-bearing animals, even though species-specific anatomic differences must be taken into account.…”

Chemotherapy-Induced Anagen Effluvium: Diffuse or Patterned?

“…Braun-Falco [3] demonstrated, after X-ray administration, an occurrence of an early, severe and transitory dystrophic anagen effluvium while a longer-lasting telogen effluvium developed late. Rebora [4] pointed out that, when an arrest of mitotic activity occurs, obviously numerous and interacting factors influence the choice of the shedding pattern.…”

Patients with profuse hair shedding may reveal anagen hair dystrophy: a diagnostic clue of alopecia areata incognita

“…However, a possible evidence that the same antimitotic insult, which is classically considered cause of anagen dystrophy, may also cause a profuse telogen shedding is provided by an old experimental observation. Braun Falco showed that the typical dystrophic hair shedding after X‐ray irradiation is followed, in the same animal, by a telogen hair shedding lasting many weeks, well beyond the cessation of dystrophy 8 . This suggests that a prevalently telogenic form of alopecia areata exists (AAI).…”

“…Anagen dystrophic hairs are well known in alopecia areata, and in sideropenic, hypocaloric and postchemotherapy alopecias. They appear at the fourth day following an antimitotic treatment (experimental irradiation with 1200–1500 r) and disappear after the fourth week 8 . In alopecia areata, they are usually detected using pull test or trichogram.…”

“…In alopecia areata, they are usually detected using pull test or trichogram. They can be observed also in histopathology 8 and are usually interpreted as corresponding to the phase of activity of the disease.…”