Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss

Jeong, Sol; Seong, Ji Hye; Kang, Ju‐Hee; Lee, Dong‐Seok; Yim, Mijung

doi:10.1002/1873-3468.13963

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…Vitamin D receptor (VDR) alleles are associated with postmenopausal osteoporosis susceptibility and bone mineral density (Zhang et al, 2018). Dynamin 1 like (DNM1L) belongs to a superfamily of GTPases, which are related to osteoclast differentia- tion and bone loss (Jeong et al, 2021). Tyrosyl-TRNA synthetase 2 (YARS2) is coupled with the impaired ability of the bone marrow to produce normal red blood cells (Riley et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Parentage testing and looking for single nucleotide markers associated with antler quality in deer (Cervus elaphus)

Elblinger

Bokor²,

Bokor³

et al. 2022

Arch. Anim. Breed.

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Abstract. To provide a cost-efficient parentage testing kit for red deer (Cervus elaphus), a 63 SNP set has been developed from a high-density Illumina BovineHD BeadChip containing 777 962 SNPs after filtering of genotypes of 50 stags. The successful genotyping rate was 38.6 % on the chip. The ratio of polymorphic loci among effectively genotyped loci was 6.5 %. The selected 63 SNPs have been applied to 960 animals to perform parentage control. Thirty SNPs out of the 63 had worked on the OpenArray platform. Their combined value of the probability of identity and exclusion probability was 4.9×10-11 and 0.99803, respectively. A search for loci linked with antler quality was also performed on the genotypes of the above-mentioned stags. Association studies revealed 14 SNPs associated with antler quality, where low-quality antlers with short and thin main beam antlers had values from 1 to 2, while high-quality antlers with long and strong main beams had values between 4 and 5. The chance for a stag to be correctly identified as having high-value antlers is expected to be over 88 %.

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Section: Discussionmentioning

confidence: 99%

Parentage testing and looking for single nucleotide markers associated with antler quality in deer (Cervus elaphus)

Elblinger

Bokor²,

Bokor³

et al. 2022

Arch. Anim. Breed.

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show abstract

“… 92 Additionally, a study has demonstrated that mitochondrial rupture triggered by the NF-κB ligand (RANKL)/GSK-3β/Drp1 axis contributes significantly to osteoblast differentiation. 94 Downregulation of Drp1 leads to impaired osteoclast differentiation and attenuates the condition in a mouse model of postmenopausal osteoporosis. 94 Based on these findings, it appears that abnormal mitochondrial dynamics may assist to the development of postmenopausal osteoporosis.…”

Section: Mitochondrial Dynamics and Cellular Functionmentioning

confidence: 99%

Mitochondrial dynamics in health and disease: mechanisms and potential targets

Chen,

Zhao,

2023

Sig Transduct Target Ther

227

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Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity and dynamic nature. These abilities allow them to effectively coordinate various cellular functions. Mitochondrial dynamics refers to the changing process of fission, fusion, mitophagy and transport, which is crucial for optimal function in signal transduction and metabolism. An imbalance in mitochondrial dynamics can disrupt mitochondrial function, leading to abnormal cellular fate, and a range of diseases, including neurodegenerative disorders, metabolic diseases, cardiovascular diseases and cancers. Herein, we review the mechanism of mitochondrial dynamics, and its impacts on cellular function. We also delve into the changes that occur in mitochondrial dynamics during health and disease, and offer novel perspectives on how to target the modulation of mitochondrial dynamics.

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“…These results suggest the RANKL/GSK-3β/DRP1 axis can promote osteoclast differentiation. DRP1 has been shown to increase osteoclast differentiation by promoting the c-fos/NFATc1 axis, while downregulation of DRP1 significantly reduced expression of c-fos and nuclear factor 1 of activated T-cells (NFATc1), inhibited osteoclast differentiation, prevented bone loss, and played a protective role in a postmenopausal OP mouse model ( 13 ). This suggests that mitochondrial dysfunction may be the underlying pathophysiological mechanism of OP in postmenopausal women ( 14 ).…”

Section: The Pathological Role Of Mitochondria In Osteoporosismentioning

confidence: 99%

Mitochondrial quality control and its role in osteoporosis

et al. 2023

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Mitochondria are important organelles that provide cellular energy and play a vital role in cell differentiation and apoptosis. Osteoporosis is a chronic metabolic bone disease mainly caused by an imbalance in osteoblast and osteoclast activity. Under physiological conditions, mitochondria regulate the balance between osteogenesis and osteoclast activity and maintain bone homeostasis. Under pathological conditions, mitochondrial dysfunction alters this balance; this disruption is important in the pathogenesis of osteoporosis. Because of the role of mitochondrial dysfunction in osteoporosis, mitochondrial function can be targeted therapeutically in osteoporosis-related diseases. This article reviews different aspects of the pathological mechanism of mitochondrial dysfunction in osteoporosis, including mitochondrial fusion and fission, mitochondrial biogenesis, and mitophagy, and highlights targeted therapy of mitochondria in osteoporosis (diabetes induced osteoporosis and postmenopausal osteoporosis) to provide novel targets and prevention strategies for the prevention and treatment of osteoporosis and other chronic bone diseases.

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Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss

Cited by 13 publications

References 28 publications

Parentage testing and looking for single nucleotide markers associated with antler quality in deer (Cervus elaphus)

Parentage testing and looking for single nucleotide markers associated with antler quality in deer (Cervus elaphus)

Mitochondrial dynamics in health and disease: mechanisms and potential targets

Mitochondrial quality control and its role in osteoporosis

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