2011
DOI: 10.1083/jcb.201003027
|View full text |Cite
|
Sign up to set email alerts
|

Dynamin2- and endothelial nitric oxide synthase–regulated invasion of bladder epithelial cells by uropathogenic Escherichia coli

Abstract: eNOS-mediated S-nitrosylation of dynamin2 promotes infection of epithelial cells by E. coli.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
19
0
3

Year Published

2012
2012
2022
2022

Publication Types

Select...
5
3

Relationship

2
6

Authors

Journals

citations
Cited by 28 publications
(24 citation statements)
references
References 37 publications
2
19
0
3
Order By: Relevance
“…It has been reported before that some UPEC strains are able to invade host bladder cells and to reproduce inside the host cell forming IBCs and that T1P contribute directly to the process of internalization [5][8]. Thus, we assayed CFT073 Δ ecpA for invasion of HeLa and HTB-4 cells through the gentamycin-protection assay.…”
Section: Resultsmentioning
confidence: 99%
“…It has been reported before that some UPEC strains are able to invade host bladder cells and to reproduce inside the host cell forming IBCs and that T1P contribute directly to the process of internalization [5][8]. Thus, we assayed CFT073 Δ ecpA for invasion of HeLa and HTB-4 cells through the gentamycin-protection assay.…”
Section: Resultsmentioning
confidence: 99%
“…One of the final steps of the internalization process leading to the formation of nascent, UPEC-containing Rab27b-positive vesicles within the host cytosol is catalyzed by the large GTPase dynamin2 (82, 92, 93). The activity of dynamin2 is enhanced by S-nitrosylation of a single cysteine residue via reaction with nitric oxide (NO) that is generated by endothelial NO synthase (NOS3) (92, 93).…”
Section: Mechanisms Of Bladder Cell Invasion By Upecmentioning
confidence: 99%
“…The activity of dynamin2 is enhanced by S-nitrosylation of a single cysteine residue via reaction with nitric oxide (NO) that is generated by endothelial NO synthase (NOS3) (92, 93). Within the bladder, the levels of NO and other reactive nitrogen species rapidly increase in response to infection (94).…”
Section: Mechanisms Of Bladder Cell Invasion By Upecmentioning
confidence: 99%
“…Forced overexpression of dynamin1 C607A, for example, reduces rate of agonist-induced β2AR internalization [47]. Similarly, overexpression of dynamin2 C86/607A decreases the bacteria invasion of bladder epithelial cells [107]. Drp1 S-nitrosylation triggers mitochondrial fission, synaptic loss, and neuronal damage that are key mediators of Alzheimer’s disease [105].…”
Section: Dynamin S-nitrosylationmentioning
confidence: 99%