Dynapenia in all-cause mortality and its relationship with sedentary behavior in community-dwelling older adults

Silva, Rízia Rocha; Galvão, Lucas Lima; Meneguci, Joilson; Santos, Douglas de Assis Teles; Júnior, Jair Sindra Virtuoso; Tribess, Sheilla

doi:10.1016/j.smhs.2022.09.002

Cited by 10 publications

(5 citation statements)

References 47 publications

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“…• Dynapenia was defined as low muscle strength with HGS below 27 kg in male participants and below 16 kg in female participants (Dodds et al, 2014;Silva et al, 2022;Wilkinson et al, 2022). The HGS used was that of the dominant hand.…”

Section: Phenotype Definitionsmentioning

confidence: 99%

Precision MRI phenotyping of muscle volume and quality at a population scale

Thanaj,

Basty,

Whitcher

et al. 2024

Front. Physiol.

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Introduction: Magnetic resonance imaging (MRI) enables direct measurements of muscle volume and quality, allowing for an in-depth understanding of their associations with anthropometric traits, and health conditions. However, it is unclear which muscle volume measurements: total muscle volume, regional measurements, measurements of muscle quality: intermuscular adipose tissue (IMAT) or proton density fat fraction (PDFF), are most informative and associate with relevant health conditions such as dynapenia and frailty.Methods: We have measured image-derived phenotypes (IDPs) including total and regional muscle volumes and measures of muscle quality, derived from the neck-to-knee Dixon images in 44,520 UK Biobank participants. We further segmented paraspinal muscle from 2D quantitative MRI to quantify muscle PDFF and iron concentration. We defined dynapenia based on grip strength below sex-specific cut-off points and frailty based on five criteria (weight loss, exhaustion, grip strength, low physical activity and slow walking pace). We used logistic regression to investigate the association between muscle volume and quality measurements and dynapenia and frailty.Results: Muscle volumes were significantly higher in male compared with female participants, even after correcting for height while, IMAT (corrected for muscle volume) and paraspinal muscle PDFF were significantly higher in female compared with male participants. From the overall cohort, 7.6% (N = 3,261) were identified with dynapenia, and 1.1% (N = 455) with frailty. Dynapenia and frailty were positively associated with age and negatively associated with physical activity levels. Additionally, reduced muscle volume and quality measurements were associated with both dynapenia and frailty. In dynapenia, muscle volume IDPs were most informative, particularly total muscle exhibiting odds ratios (OR) of 0.392, while for frailty, muscle quality was found to be most informative, in particular thigh IMAT volume indexed to height squared (OR = 1.396), both with p-values below the Bonferroni-corrected threshold (p<8.8×10−5).Conclusion: Our fully automated method enables the quantification of muscle volumes and quality suitable for large population-based studies. For dynapenia, muscle volumes particularly those including greater body coverage such as total muscle are the most informative, whilst, for frailty, markers of muscle quality were the most informative IDPs. These results suggest that different measurements may have varying diagnostic values for different health conditions.

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Section: Phenotype Definitionsmentioning

confidence: 99%

Precision MRI phenotyping of muscle volume and quality at a population scale

Thanaj,

Basty,

Whitcher

et al. 2024

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…• Dynapenia was defined as low muscle strength with HGS below 27 kg in male participants and below 16 kg in female participants (Dodds et al, 2014(Dodds et al, , 2020Silva et al, 2022;Wilkinson et al, 2022). The HGS used was that of the dominant hand.…”

Section: Phenotype Definitionsmentioning

confidence: 99%

Precision MRI phenotyping of muscle volume and quality at a population scale

Thanaj

Basty

Whitcher

et al. 2023

Preprint

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BackgroundMagnetic resonance imaging (MRI) enables direct measurements of muscle volume and quality, allowing for an in-depth understanding of their associations with anthropometric traits, and health conditions. However, it is unclear which muscle measurements: total muscle volume, regional measurements or measurements of muscle quality, such as intermuscular adipose tissue (IMAT) or proton density fat fraction (PDFF), are most informative to detect changes and associations with relevant health outcomes such as sarcopenia and frailty.MethodsWe developed a pipeline to automatically segment and extract image-derived phenotypes (IDPs) including total and regional muscle volumes and measures of muscle quality, and applied it to the neck-to-knee Dixon images in 44,520 UK Biobank participants. We also segmented paraspinal muscle from 2D quantitative MRI to quantify muscle PDFF and iron concentration. We performed linear regression to assess associations with anthropometric and lifestyle factors. We further applied logistic regression to investigate the association between these IDPs and sarcopenia and frailty.ResultsAll muscle measurements were negatively associated with age, waist-to-hip ratio, and Townsend deprivation index while they were positively associated with body mass index, alcohol intake, hand grip strength, physical activity and were significantly higher in men. Additionally, IMAT, (corrected for muscle volume) and paraspinal muscle PDFF were significantly higher in female compared with male participants. Sarcopenia was associated with reduced muscle volume, while frailty was associated with increased IMAT and paraspinal PDFF.ConclusionsOur fully automated method enables the quantification of muscle volumes and quality suitable for large population-based studies. While the choice of muscle measurements is important particularly when investigating associations with health conditions, most provide consistent differences relating to the detection of age, sex, body composition and lifestyle changes on muscularity.

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“…Furthermore, older adults with dynapenia are at greater risks of functional disability 14 and mortality. 15,16 Handgrip strength (HGS) is a primary criterion for diagnosing muscle weakness. This is because this method is considered the gold standard, as it is a direct measure of functional performance and has a good correlation with global muscle strength.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, older adults with dynapenia are at greater risks of functional disability 14 and mortality. 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

Habitual physical activity and sedentary behavior as predictors of dynapenia in older adults: a cross-sectional study

Santos,

Almeida,

Valença Neto

et al. 2024

Sao Paulo Med. J.

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BACKGROUND: Dynapenia is a risk factor of mortality. Therefore, the development of low-cost and easyto-apply tools is essential to optimize the health surveillance actions of older people. OBJECTIVES: To compare the time spent on habitual physical activity (HPA) and sedentary behavior (SB) among dynapenic and non-dynapenic older adults and ascertain the predictive ability of these behaviors on outcome. DESIGN AND SETTING: A cross-sectional population epidemiological survey was conducted involving 208 older adults. METHODS: HPA and SB were quantified using the International Physical Activity Questionnaire, and dynapenia was identified by handgrip strength (women: 18.37 kgf; men: 26.75 kgf ). RESULTS: The prevalence was 24.50%. In both sexes, dynapenic individuals reported a HPA median time of 70.00 minutes/week (min/wk), while non-dynapenic women and men reported HPA median times of 240.00 and 280.00 min/wk, respectively (P < 0.05). For SB among dynapenic individuals, a median of 388.75 min/day was observed in women and 428.57 min/d in men. In contrast, non-dynapenic women and men had 291.42 and 274.28 min/day in SB (P < 0.05), respectively. The best cutoff HPA to discriminate the outcome was 150.00 min/wk in women (sensitivity: 73.30%; specificity: 60.67%) and 140.00 min/wk in men (sensitivity, 71.43%; specificity, 61.54%). The best cutoff SB was 381.43 min/day in women (sensitivity, 53.30%; specificity, 84.80%) and 351.43 min/day in men (sensitivity, 71.43%; specificity, 73.85%). CONCLUSION: Older individuals with dynapenia spent less time on HPA and more time in SB. Furthermore, HPA was found to be a better discriminator of dynapenic individuals, and SB better discriminated non-dynapenic individuals.

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Dynapenia in all-cause mortality and its relationship with sedentary behavior in community-dwelling older adults

Cited by 10 publications

References 47 publications

Precision MRI phenotyping of muscle volume and quality at a population scale

Precision MRI phenotyping of muscle volume and quality at a population scale

Precision MRI phenotyping of muscle volume and quality at a population scale

Habitual physical activity and sedentary behavior as predictors of dynapenia in older adults: a cross-sectional study

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