Dynapenia in digestive cancer outpatients: association with markers of functional and nutritional status (the FIGHTDIGO study)

Perrier, Marine; Ordan, Marie-Amélie; Barbe, Coralie; Mazza, Camille; Botsen, Damien; Moreau, Johanna; Renard, Yohann; Brasseur, Mathilde; Tailliere, Barbara; Regnault, P.; Bertin, Éric; Bouché, Olivier

doi:10.1007/s00520-021-06416-1

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…Indeed, patients with exploratory low HGS were significantly older and had a worse ECOG PS, mGPS score, and geriatric G8 score. Our results are in line with the known association of low HGS with markers of functional and nutritional status [ 18 , 25 ], age [ 26 ], and geriatric G8 score [ 27 ]. These findings support the usefulness of HGS measurement as an interesting additional tool to identify frailty in cancer patients.…”

Section: Discussionsupporting

confidence: 90%

“…The HGS measurement protocol was previously described by Ordan et al [ 18 ]. There were 5 possible handle positions, and position 2 is used in our daily practice.…”

Section: Methodsmentioning

confidence: 99%

“…In cancer patients, dynapenia has been associated with cancer-related fatigue [ 14 ], poor quality of life [ 15 ], postoperative complications [ 16 ], and mortality [ 17 ]. HGS could also be a reliable and effective tool to screen for malnutrition in digestive cancer patients [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

et al. 2022

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In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limiting toxicity (DLT) or all-grade toxicity in digestive cancer patients. HGS measurement was performed with a Jamar dynamometer. Dynapenia was defined according to EWGSOP2 criteria (<27 kg (men); <16 kg (women)). DLT was defined as any toxicity leading to dose reduction, treatment delay, or permanent discontinuation. We also performed an exploratory analysis in patients below the included population’s median HGS. A total of 244 patients were included. According to EWGSOP2 criteria, 23 patients had pre-therapeutic dynapenia (9.4%). With our exploratory median-based threshold (34 kg for men; 22 kg for women), 107 patients were dynapenic (43.8%). For each threshold, dynapenia was not an independent predictive factor of overall DLT and neurotoxicity. Dynapenic patients according to EWGSOP2 definition experienced more hand-foot syndrome (p = 0.007). Low HGS according to our exploratory threshold was associated with more all-grade asthenia (p = 0.014), anemia (p = 0.006), and asthenia with DLT (p = 0.029). Pre-therapeutic dynapenia was not a predictive factor for overall DLT and neurotoxicity in digestive cancer patients but could be a predictive factor of chemotherapy-induced anemia and asthenia. There is a need to better define the threshold of dynapenia in cancer patients.

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Section: Discussionsupporting

confidence: 90%

“…The HGS measurement protocol was previously described by Ordan et al [ 18 ]. There were 5 possible handle positions, and position 2 is used in our daily practice.…”

Section: Methodsmentioning

confidence: 99%

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Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

et al. 2022

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“…In addition, patients with low FPP before starting anticancer therapy had higher neurotoxicity induced by chemotherapy. In our study, we observed a low FPP of 7.4%; this lower prevalence may be related to the heterogeneity of our sample, since we did not de ne the primary tumor location for patient selection, as was performed in the study by Perrier et al (2022), which evaluated only patients with neoplasia in the digestive tract.…”

Section: Discussionmentioning

confidence: 74%

“…In a prospective study (Perrier et al, 2022), whose objective was to evaluate the association between muscle strength and nutritional markers in patients with digestive neoplasm receiving chemotherapy, patients showed loss of muscle strength in 20.1% of the evaluations as well as impairment of functional status. In addition, patients with low FPP before starting anticancer therapy had higher neurotoxicity induced by chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Physical and functional evaluations in oncological patients elective to medium and large operations

Vieira

Machado

Faria

et al. 2023

Support Care Cancer

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Purpose: To evaluate the physical and functional capacity and the risk of sarcopenia on the length of hospital stay and deaths in preoperative cancer patients. Methods: Preoperative patients admitted to the Cancer Hospital of Mato Grosso comprised the sample. Sociodemographic data, lifestyle data, and a questionnaire for sarcopenia screening were collected. Subsequently, total body mass, height, muscle strength, muscle mass, and physical performance were evaluated. The data were tabulated and analyzed using the statistical software SPSS (25.0). The signi cance level was 5%. Results: We observed 12 (7.4%) patients with low muscle strength, 20 (12.3%) patients with low muscle mass, 11 (6.8%) patients with low physical performance, and 18 (11.1%) patients with scores for possible sarcopenia. When the risk of sarcopenia was observed, 44 (27.2%) patients had at least one risk related to muscle disorder. When analyzing the prevalence and association of sarcopenia with sociodemographic variables, we observed that education level was associated with sarcopenia (p = 0.031). In addition, there was an association between preoperative sarcopenia and postoperative death (p = 0.006). Finally, there were important correlations between muscle strength and physical performance (p <0.05), between muscle strength and the sarcopenia questionnaire (p <0.001), and between physical performance and the sarcopenia questionnaire (p <0.05). Conclusion: The results suggest the need for counseling and the need to evaluate patients for risk of sarcopenia, since early intervention, such as dietary supplementation and physical exercise, may favor a better postoperative prognosis, possibly corresponding to shorter hospital stays and longer survival and quality of life for patients, especially those who will undergo surgical procedures.

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Routine assessment of nutritional, functional and inflammatory criteria in patients with cancer: A systematic review

Pumtako,

Dolan,

McGovern

et al. 2024

Clinical Nutrition ESPEN

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Dynapenia in digestive cancer outpatients: association with markers of functional and nutritional status (the FIGHTDIGO study)

Cited by 7 publications

References 44 publications

Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

Physical and functional evaluations in oncological patients elective to medium and large operations

Routine assessment of nutritional, functional and inflammatory criteria in patients with cancer: A systematic review

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