Dynapenic-abdominal obesity as an independent risk factor for chronic kidney disease in postmenopausal women: a population-based cohort study

Choi, Youngju; Cho, Jinkyung; Kim, Jiyeon; Bae, Jun Hyun; Cho, Eun‐Jeong; Chang, Eunwook; Joa, Kyung-Lim; Kim, Jung-Hoon; Park, Dong‐Ho; Kang, Ju‐Hee; Kwak, Hyo‐Bum

doi:10.1097/gme.0000000000002032

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…However, this previous study excluded subjects with severe CKD symptoms, and the number of subjects was small, including only 123 patients with CKD. In another previous study, the incidence of CKD was 1.82 times higher in postmenopausal women than in healthy participants [40]. However, this previous study was disadvantaged in that there is a criterion for subjects who are postmenopausal women.…”

Section: Discussionmentioning

confidence: 83%

Association between Chronic Kidney Disease and Dynapenia in Elderly Koreans

Lee,

Shin

2023

Healthcare

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Chronic kidney disease (CKD) is caused by various factors such as chronic inflammation, oxidative stress, and obesity. Loss of muscle strength and mass is a negative prognostic factor for CKD. Therefore, in this study, we aimed to investigate the association between CKD and dynapenia in the Korean elderly. To this end, we analyzed 7029 participants from the 2014–2019 Korean National Health and Nutrition Examination Survey (KNHANES) aged ≥65 years. After adjusting for all of the covariates that could affect the results, such as physical examinations, lifestyle factors, and exercise, the association between CKD and dynapenia was found to be significant, at 1.207 (95% CI: 1.056–1.379) in CKD stage 2 and 1.790 (95% CI: 1.427–2.246) in CKD stage 3a–5. However, when sexes were analyzed separately, women were significant in both CKD stage 2 and stage 3–5 compared to normal, but only in stage 3–5 for men. Additionally, the prevalence of dynapenia increased significantly as the stage of CKD increased (normal, stage 2, and stage 3–5: 18.5%, 20.8%, and 32.3% in men and 27.5%, 34.4%, and 46.1% in women, respectively). Thus, CKD is significantly related to dynapenia, especially in women, when stratified by sex.

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Section: Discussionmentioning

confidence: 83%

Association between Chronic Kidney Disease and Dynapenia in Elderly Koreans

Lee,

Shin

2023

Healthcare

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“…8 Furthermore, hormonal changes during menopause can lead to obesity. Choi et al 9 reported that abdominal obesity in postmenopausal women was an independent risk factor for the development of CKD.…”

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confidence: 99%

Chronic kidney disease in postmenopausal women is associated with tooth loss

Kim,

Choi

et al. 2024

Menopause

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Objective Menopause is characterized by changes in reproductive hormone levels that can negatively affect bone. Chronic kidney disease (CKD) and tooth loss are also important and common health issues after menopause. This study aimed to evaluate the association between CKD and tooth loss in postmenopausal women. Methods The study evaluated 64,971 participants who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) from 2010-2018, including postmenopausal women, aged 40 to 79 years. Participants were divided into two groups based on the number of teeth in their dentition (≥20 and <20). Main Outcome Measures The association between CKD and tooth loss was analyzed using multivariate logistic regression. Age, income, education, smoking, alcohol intake, body mass index, hypertension, diabetes, annual oral examination, toothbrushing, and the use of oral care products were considered. Subgroup analyses were further conducted according to age (40-65 yr and 66-79 yr). Results After adjusting for covariates, CKD and estimated glomerular filtration rate were significantly associated with having ≥20 teeth (PT20; CKD: odds ratio [OR] 1.41, 95% confidence interval [CI] 1.04-1.90; estimated glomerular filtration rate (10 mL/min/1.73 m2): OR 0.90, 95% CI 0.86-0.94). Importantly, the association between CKD and PT20 was significant in postmenopausal women, aged 66 to 79 years (OR 1.45, 95% CI 1.05-2.01). Conclusions In postmenopausal women, CKD and tooth loss may be associated. The association is significant in postmenopausal women, aged 66 to 79 years.

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Association between dynapenic obesity phenotypes and physical performance in middle-age and older women living in community

Arteaga-Pazmiño,

Fonseca-Pérez,

Balladares Mazzini

et al. 2024

Front. Nutr.

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BackgroundDynapenic obesity (DO) is the coexistence of excess adipose tissue/body weight and low muscle strength. This condition is associated with an increased risk of suffering from various chronic diseases and physical deterioration in older people.AimTo analyze the association between DO phenotypes and physical performance in middle-aged women living in the community.MethodsThis cross-sectional study was conducted on middle-aged and older women (≥50 years) residing in Guayaquil, Ecuador. Dynapenia was diagnosticated by a handgrip strength (HGS) < 16 kg; obesity was determined based on body mass index (BMI) ≥ 30 kg/m2. Participants were categorized into four groups based on their dynapenia and obesity status: non-dynapenic/non-obesity (ND/NO), obesity/non-dynapenic (O/ND), dynapenic/non-obesity (D/NO) and dynapenic/obesity (D/O). Physical performance was assessed by the Short Physical Performance Battery (SPPB).ResultsA total of 171 women were assessed. The median (IQR) age of the sample was 72.0 (17.0) years. Obesity and dynapenia were 35% (n = 60) and 57.8% (n = 99) of the participants, respectively. The prevalence of ND/NO was 25.1% (n = 43), O/ND 17% (n = 29), D/NO 39.8% (n = 68) and DO 18.1% (n = 31). The mean SPPB total score was 6.5 ± 3.2. Participants of D/NO and DO groups presented significantly lower mean SPPB scores (p < 0.001) compared to those of NO/ND and O/ND groups.ConclusionWomen with DO and D/NO exhibited significantly lower SPPB scores, indicating poorer physical performance. These findings emphasize the importance of incorporating a comprehensive assessment of muscle strength and obesity in middle-aged and older women.

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Dynapenic-abdominal obesity as an independent risk factor for chronic kidney disease in postmenopausal women: a population-based cohort study

Cited by 3 publications

References 54 publications

Association between Chronic Kidney Disease and Dynapenia in Elderly Koreans

Association between Chronic Kidney Disease and Dynapenia in Elderly Koreans

Chronic kidney disease in postmenopausal women is associated with tooth loss

Association between dynapenic obesity phenotypes and physical performance in middle-age and older women living in community

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