Dynapenic abdominal obesity is related to cardiovascular risk in older adults with Parkinson's disease: A cross sectional study

Introduction People with Parkinson’s disease may pre-sent muscle weakness. The handgrip test is used to identify upper limbs strength. There are different protocol descriptions of this assessment. Objective To carry out a systematic review on the assessment of handgrip strength in people with Parkinson’s. Methods The review was carried out according to the PRISMA guidelines, the PubMed, SciELO, LILACS and Scopus literary databases, and registered at PROSPERO (CRD420201 9018). Quantitative analysis was performed using the Newcastle-Ottawa Scale. Twenty-seven articles were analyzed. Results The most referenced protocol is that of the American Society of Hand Therapists. The most used instrument is the hydraulic dynamometer. Of the sixteen studies that compared handgrip strength be-tween people with Parkinson’s and healthy people, seven identified a statistically significant difference. No article was classified as unsatisfactory. Conclusion It is not possible to affirm that handgrip strength is reduced in Parkinson’s disease, when compared to healthy subjects. Protocol and instrument standardization can help com-parisons between results from different studies. There are few longitudinal studies, making it difficult to under-stand what happens to handgrip strength as the disease progresses.

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Obesity versus underweight: the prognostic impact of body mass phenotypes in hospitalized older patients

Pereira,

Pinho,

Santos

et al. 2024

Geriatr Gerontol Aging

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Objective: To compare the frequency of underweight and obesity among previously hospitalized older adults and analyze their association with malnutrition, sarcopenia, frailty, inflammatory markers, and adverse outcomes both during hospitalization and after discharge. Methods: This secondary analysis of a prospective study, conducted at Hospital das Clínicas da Universidade Federal de Pernambuco, Brazil, included hospitalized older patients (age ≥ 60 y). Nutritional status, body composition, sarcopenia, frailty, and outcomes were assessed. Cox regression was performed to evaluate the impact of the body mass phenotypes on clinical outcomes. Results: This secondary analysis included one hundred patients. The prevalence of obesity was 22.10%, while that of underweight was 34.60%. Individuals with underweight had a higher frequency of weaker immune response, worse inflammatory profile, higher nutritional risk, higher frequency of sarcopenia and malnutrition, longer hospital stay, and a higher incidence of mortality when compared to those with obesity. Being underweight was independently associated with higher mortality rates, even after adjustment for age, sex, muscle mass, malnutrition, and diagnosis of malignancy [adjusted HR = 2.82 (95% confidence interval 1.03 – 7.72), p = 0.044]. Conclusion: The underweight phenotype represented a worst-case scenario in hospitalized older patients.

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Dynapenic abdominal obesity is related to cardiovascular risk in older adults with Parkinson's disease: A cross sectional study

Cited by 3 publications

References 24 publications

Dynapenic Abdominal Obesity and Metabolic Health in Non-Geriatric Patients with Obesity

Dynapenic Abdominal Obesity and Metabolic Health in Non-Geriatric Patients with Obesity

Handgrip strength in Parkinson’s disease: A systematic review of observational studies

Obesity versus underweight: the prognostic impact of body mass phenotypes in hospitalized older patients

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