Dynein Light Chain DLC-1 Facilitates the Function of the Germline Cell Fate Regulator GLD-1 in <i>Caenorhabditis elegans</i>

Ellenbecker, Mary; Osterli, Emily; Wang, Xiaobo; Day, Nicholas; Baumgarten, Ella B; Hickey, Benjamin; Voronina, Ekaterina

doi:10.1534/genetics.118.301617

Cited by 12 publications

(6 citation statements)

References 48 publications

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“…In mouse models, the mutation or loss of HMMR/Hmmr expression also disrupts the correct development or homeostasis of gonadal tissues [7,50,51]. While the mechanisms responsible are yet to be determined, these phenotypes are likely reflective of the high expression of HMMR in gonadal tissues and the necessary role played by dynein, and its adaptor proteins, during the processes of gametogenesis and spermatogenesis [52][53][54].…”

Section: Hmmr Is Needed For Tissue Homeostasis and Neural Developmentmentioning

confidence: 99%

Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor

Mei

Connell

et al. 2020

Cells

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Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement. Consequently, CD44 demarks stem cells in normal tissues and tumor-initiating cells isolated from neoplastic tissues. Hyaluronan mediated motility receptor (HMMR, also known as RHAMM) is another one of few defined hyaluronan receptors. HMMR is also associated with neoplastic processes and its role in cancer progression is often attributed to hyaluronan-mediated signaling. But, HMMR is an intracellular, microtubule-associated, spindle assembly factor that localizes protein complexes to augment the activities of mitotic kinases, like polo-like kinase 1 and Aurora kinase A, and control dynein and kinesin motor activities. Expression of HMMR is elevated in cells prior to and during mitosis and tissues with detectable HMMR expression tend to be highly proliferative, including neoplastic tissues. Moreover, HMMR is a breast cancer susceptibility gene product. Here, we briefly review the associations between HMMR and tumorigenesis as well as the structure and evolution of HMMR, which identifies Hmmr-like gene products in several insect species that do not produce hyaluronan. This review supports the designation of HMMR as a homeostasis, mitosis, and meiosis regulator, and clarifies how its dysfunction may promote the tumorigenic process and cancer progression.

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Section: Hmmr Is Needed For Tissue Homeostasis and Neural Developmentmentioning

confidence: 99%

Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor

Mei

Connell

et al. 2020

Cells

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“…It was reported that DLC-1 of C. elegans and Plasmodium falciparum played an important role in growth and germ cell proliferation and gametogenesis in vivo (Daher et al, 2010;Ellenbecker et al, 2019). DLC-1 (Sjp_0057280), which is involved in microtubule-based process/microtubule-associated complex/microtubule cytoskeleton, was also identified as differentially expressed in female schistosomes from SCID mice when compared with those from BALB/c mice.…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptome Analyses of Schistosoma japonicum Derived From SCID Mice and BALB/c Mice: Clues to the Abnormality in Parasite Growth and Development

Liu¹,

Cheng²,

Ye³

et al. 2020

Front. Microbiol.

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Frontiers in Microbiology | www.frontiersin.org March 2020 | Volume 11 | Article 274 Liu et al.Transcriptome Analysis of S. japonicum From Mice expression profiles of schistosomes from SCID mice when compared with those from BALB/c mice, which were potentially involved in regulating the growth and development of schistosomes. These findings contributed to an understanding of parasite biology and provided a rich resource for the exploitation of antischistosomal intervention targets.

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“…In GSCs, transcription of the differentiation factor bam is repressed by the BMP signaling pathway FIGURE 5 | Schematic illustrating some components that regulate C. elegans germline development, including the Puf family members FBF-1 and FBF-2. Modeled after Ellenbecker et al (2019). (Chen and McKearin, 2003a,b;Song et al, 2004;Chen and McKearin, 2005).…”

Section: The Regulation Of Drosophila Germ Cell Differentiation By Mrna Translation Based Mechanismsmentioning

confidence: 99%

“… Schematic illustrating some components that regulate C. elegans germline development, including the Puf family members FBF-1 and FBF-2. Modeled after Ellenbecker et al (2019) . …”

Section: Rna Binding Proteins and The Regulated Translation Of Mrnas During Germ Cell Formationmentioning

confidence: 99%

The Dynamic Regulation of mRNA Translation and Ribosome Biogenesis During Germ Cell Development and Reproductive Aging

Mercer

Jang

et al. 2021

Front. Cell Dev. Biol.

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The regulation of mRNA translation, both globally and at the level of individual transcripts, plays a central role in the development and function of germ cells across species. Genetic studies using flies, worms, zebrafish and mice have highlighted the importance of specific RNA binding proteins in driving various aspects of germ cell formation and function. Many of these mRNA binding proteins, including Pumilio, Nanos, Vasa and Dazl have been conserved through evolution, specifically mark germ cells, and carry out similar functions across species. These proteins typically influence mRNA translation by binding to specific elements within the 3′ untranslated region (UTR) of target messages. Emerging evidence indicates that the global regulation of mRNA translation also plays an important role in germ cell development. For example, ribosome biogenesis is often regulated in a stage specific manner during gametogenesis. Moreover, oocytes need to produce and store a sufficient number of ribosomes to support the development of the early embryo until the initiation of zygotic transcription. Accumulating evidence indicates that disruption of mRNA translation regulatory mechanisms likely contributes to infertility and reproductive aging in humans. These findings highlight the importance of gaining further insights into the mechanisms that control mRNA translation within germ cells. Future work in this area will likely have important impacts beyond germ cell biology.

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Dynein Light Chain DLC-1 Facilitates the Function of the Germline Cell Fate Regulator GLD-1 in Caenorhabditis elegans

Cited by 12 publications

References 48 publications

Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor

Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor

Comparative Transcriptome Analyses of Schistosoma japonicum Derived From SCID Mice and BALB/c Mice: Clues to the Abnormality in Parasite Growth and Development

The Dynamic Regulation of mRNA Translation and Ribosome Biogenesis During Germ Cell Development and Reproductive Aging

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