Dynorphin A (1–8) inhibits oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA receptor and κ-opioid receptor channels

Chen, Mengying; Zhang, Xiaodong; Fan, Jiaxin; Sun, Hong; Yao, Qingling; Shi, Jiachen; Qu, Huiyang; Du, Shuang; Cheng, Yuxuan; Ma, Shuyin; Zhang, Meijuan; Zhan, Shuqin

doi:10.1016/j.npep.2021.102182

Cited by 6 publications

(7 citation statements)

References 45 publications

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“…The therapeutic effect in rats with MCAO was provided by another synthetic dynorphin A(1-8) peptide [70] (Table 1). This peptide is a fragment of dynorphin A with strong opioid activity.…”

Section: Peptides That Mimic Natural Regulatory Peptides and Hormonesmentioning

confidence: 99%

“…This peptide is a fragment of dynorphin A with strong opioid activity. Dynorphin A(1-8) (YGGFLRRI) has been shown to inhibit oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA receptor and κ-opioid receptor channels [70]. In MCAO-treated rats, intranasal administration of dynorphin A(1-8) showed better behavioral improvement, a higher extent of Bcl-2 and activity of SOD, along with a much lower level of infarction volume, brain water content, number of cell apoptosis, extent of Bax, and Caspase-3 compared to the control [70].…”

Section: Peptides That Mimic Natural Regulatory Peptides and Hormonesmentioning

confidence: 99%

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Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries

Dergunova

Filippenkov

Limborska

et al. 2023

Genes

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Ischemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic targets and potential neuroprotectors. Today, in the development of neuroprotective drugs for the treatment of stroke, special attention is paid to peptides. Namely, peptide action is aimed at blocking the cascade of pathological processes caused by a decrease in blood flow to the brain tissues. Different groups of peptides have therapeutic potential in ischemia. Among them are small interfering peptides that block protein–protein interactions, cationic arginine-rich peptides with a combination of various neuroprotective properties, shuttle peptides that ensure the permeability of neuroprotectors through the blood–brain barrier, and synthetic peptides that mimic natural regulatory peptides and hormones. In this review, we consider the latest achievements and trends in the development of new biologically active peptides, as well as the role of transcriptomic analysis in identifying the molecular mechanisms of action of potential drugs aimed at the treatment of ischemic stroke.

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“…The therapeutic effect in rats with MCAO was provided by another synthetic dynorphin A(1-8) peptide [70] (Table 1). This peptide is a fragment of dynorphin A with strong opioid activity.…”

Section: Peptides That Mimic Natural Regulatory Peptides and Hormonesmentioning

confidence: 99%

Section: Peptides That Mimic Natural Regulatory Peptides and Hormonesmentioning

confidence: 99%

Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries

Dergunova

Filippenkov

Limborska

et al. 2023

Genes

View full text Add to dashboard Cite

show abstract

“…A representative of this family of peptides, the octapeptide dynorphin A (1)(2)(3)(4)(5)(6)(7)(8), is considered a natural ligand of KOP. However, it also activates MOP, DOP, and NMDA (N-methyl-D-aspartate) receptors [39,40]. Dynorphin A (1-8) has a role in the modulation of analgesia, stress, emotional states, and memory, to mention a few [24].…”

Section: Dynorphinsmentioning

confidence: 99%

“…Dynorphin A (1-8) has a role in the modulation of analgesia, stress, emotional states, and memory, to mention a few [24]. It also has a role in neuroprotection by inhibiting apoptosis and oxidative stress mechanisms [40].…”

Section: Dynorphinsmentioning

confidence: 99%

“…Recent research focuses on distribution and capacities related to their function and dysfunction in different path ogies, including cancer (see, for example, [42,[94][95][96][97][98][99]). When opioid ligands bind to the classical OR, conformational changes determine the recruitment of signaling transducers Gi/o heterotrimeric protein or β-arrestin [20,40,74,[100][101][102] (Figure 9). Upon G-protein activation, the heterotrimer dissociates.…”

Section: The Distribution Of Ormentioning

confidence: 99%

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Involvement of the Opioid Peptide Family in Cancer Progression

2023

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Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis. Tumor cells overexpress peptide receptors, crucial targets for developing specific treatments against cancer cells using peptide receptor antagonists and promoting apoptosis in tumor cells. Opioids exert an antitumoral effect, whereas others promote tumor growth and metastasis. This review updates the findings regarding the involvement of opioid peptides (enkephalins, endorphins, and dynorphins) in cancer development. Anticancer therapeutic strategies targeting the opioid peptidergic system and the main research lines to be developed regarding the topic reviewed are suggested. There is much to investigate about opioid peptides and cancer: basic information is scarce, incomplete, or absent in many tumors. This knowledge is crucial since promising anticancer strategies could be developed alone or in combination therapies with chemotherapy/radiotherapy.

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Dose-effect relationship between electroacupuncture with different parameters and the regulation of endogenous opioid peptide system

Chen

ZHANG

et al. 2023

World Journal of Acupuncture - Moxibustion

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Dynorphin A (1–8) inhibits oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA receptor and κ-opioid receptor channels

Cited by 6 publications

References 45 publications

Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries

Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries

Involvement of the Opioid Peptide Family in Cancer Progression

Dose-effect relationship between electroacupuncture with different parameters and the regulation of endogenous opioid peptide system

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