Dynorphin and its role in alcohol use disorder

Karkhanis, Anushree N.; Al‐Hasani, Ream

doi:10.1016/j.brainres.2020.146742

Cited by 37 publications

(23 citation statements)

References 182 publications

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“…However, our thesis here, based on its known dysphoric effects, its relationships to CRH and OT, and the neuroendocrine changes induced by pair bonding in prairie voles, is that the κ opioid system is also likely to be involved, particularly in the dysphoric aspects of partner loss. The KOR is a G-coupled receptor [ 53 ] with only one known ligand, dynorphin, which also has bioactive fragments [ 54 ]. As it is activated by CRH, and in turn modulates OT, we suggest that KOR is a ‘missing link’ in our understanding of the separation response.…”

Section: Neuroendocrine Systems Studied In Animal Modelsmentioning

confidence: 99%

Interactions between theκopioid system, corticotropin-releasing hormone and oxytocin in partner loss

Bales

Rogers

2022

Phil. Trans. R. Soc. B

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Selective adult social attachments, or ‘pair bonds’, represent central relationships for individuals in a number of social species, including humans. Loss of a pair mate has emotional consequences that may or may not diminish over time, and that often translate into impaired psychological and physical health. In this paper, we review the literature on the neuroendocrine mechanisms for the emotional consequences of partner loss, with a special focus on hypothesized interactions between oxytocin, corticotropin-releasing hormone and the κ opioid system. This article is part of the theme issue ‘Interplays between oxytocin and other neuromodulators in shaping complex social behaviours’.

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Section: Neuroendocrine Systems Studied In Animal Modelsmentioning

confidence: 99%

Interactions between theκopioid system, corticotropin-releasing hormone and oxytocin in partner loss

Bales

Rogers

2022

Phil. Trans. R. Soc. B

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“…Indeed, several reports have indicated a specific role of the Dyn/KORs in the intersection of stress and addiction (Beardsley, Howard, Shelton, & Carroll, 2005;McLaughlin, Land, Li, Pintar, & Chavkin, 2006;Nygard, Hourguettes, Sobczak, Carlezon, & Bruchas, 2016;Redila & Chavkin, 2008;Schindler et al, 2012). In the specific case of alcohol, several reports pointed to the Dyn/KORs as a key modulator of different alcohol addiction-related behaviors (see Karkhanis & Al-Hasani, 2020) (Table 1). The pharmacological activation of the KOR seems to induce an increase in alcohol intake in both dependent and nondependent mice (Anderson & Becker, 2017), and to potentiate ethanol-induced place preference (Sperling et al, 2010).…”

Section: Alcohol Use Disorder Is Also a Stress-related Condition: Involvement Of The Dyn/kors In The Mclsmentioning

confidence: 99%

“…Dyn/KORs is an important component of the regulation of negative affect, stress, and addiction through the modulation of the dopamine release in the NAc. Both Dynorphin (dyn) and KORs are expressed in mesocorticolimbical areas that are interconnected, such as CeA and BLA, NAc, and VTA as depicted in this scheme (Kang-Park, Kieffer, Roberts, Siggins, & Moore, 2013;Karkhanis & Al-Hasani, 2020;Przybysz, Werner, & Diaz, 2017;Stamatakis et al, 2014). In the NAc, Dyn/KORs modulates the neurotransmission of serotonin, glutamate, and dopamine(Karkhanis & Al- Hasani, 2020;Massaly et al, 2019;Tejeda et al, 2017).…”

mentioning

confidence: 99%

“…Both Dynorphin (dyn) and KORs are expressed in mesocorticolimbical areas that are interconnected, such as CeA and BLA, NAc, and VTA as depicted in this scheme (Kang-Park, Kieffer, Roberts, Siggins, & Moore, 2013;Karkhanis & Al-Hasani, 2020;Przybysz, Werner, & Diaz, 2017;Stamatakis et al, 2014). In the NAc, Dyn/KORs modulates the neurotransmission of serotonin, glutamate, and dopamine(Karkhanis & Al- Hasani, 2020;Massaly et al, 2019;Tejeda et al, 2017). This figure represents the most important areas and connections in MCLS where the Dyn/KORs might play a pivotal role in connecting pain, stress, and addiction.…”

mentioning

confidence: 99%

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Pain‐induced alterations in the dynorphinergic system within the mesocorticolimbic pathway: Implication for alcohol addiction

Lorente

Cuitavi

Hipólito

2020

J of Neuroscience Research

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The International Association for the Study of Pain (IASP) defines pain "as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage" (IASP Task Force on Taxonomy, 1994). As an emotional experience, pain usually negatively impacts patients' daily lives, not only because of physical impairment but also because of the appearance of neuropsychiatric comorbidities such as depression, anxiety, or even addiction. Because of this complex situation, treating pain and its associated neuropsychiatric pathologies becomes a difficult task for the health-care personnel.Pain and reward are opposed responses processed by interconnected brain areas that keep an adequate cognitive and emotional function (i.e., anterior cingulate cortex, dorsal striatum, and amygdala). Furthermore, pain can modify reward processing by decreasing dopamine (DA) release in nucleus accumbens (NAc), which leads to anhedonia or a negative affect state (Elman, Borsook, & Volkow, 2013;Massaly et al., 2019). Thereby, pain can be an important factor affecting addiction, especially in people with a previous history of drug abuse. In fact, inflammatory pain produces mu opioid receptor (MOR) desensitization and/or a reduction in its levels in the mesocorticolimbic system (MCLS;Ozaki et al., 2002;Zubieta et al., 2001). Interestingly, rats presenting inflammatory pain needed higher doses of heroin to

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“…Bu nöropeptid, öncelikle ödül arama, motivasyon işleme, stres tepkisi ve ağrı duyarlılığını düzenleyen ve böylece madde ve alkol kullanım bozukluğunun gelişimini etkileyen nöronal yolakları modüle eder(29). Dinorfin beyinde birçok bölgede yoğun olarak bulunmasının yanı sıra amigdala, entorinal korteks, dentat girus, hipotalamus, orta beyin, striatum, hipokampus ve medulla-ponsta (29) serebellum ve kortekse oranla daha yüksek seviyelerde bulunur(29). Kronik ağrı, amigdaladaki κ opioid reseptörü üzerinde stresi uyaran endojen dinorfin aracılı etkilerle ilişkilidir.…”

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