“…In many cancer cell lines, depletion of DYRK1B impairs cell survival and induces apoptosis, concomitant with increased intracellular levels of ROS and phosphorylation of histone 2AX on Ser139, which indicates DNA damage (Table 1). DYRK1B upregulates Increased ROS levels and increased DNA damage [12,53] EHT [68], Ro [53] Reduced growth and increased apoptosis of spheroid cells [39] EHT [68] Sensitization to mTOR inhibition [39] Ro [68], EHT [69], AZ [40] Reduced size of Panc1 and L3.6pl xenografts [39] EHT a [68], DYRKi b [39] Ovarian cancer SKOV3, TOV21G, OVCAR3, OVCAR5, OVCAR8, Hey, and primary cell lines…”