Dysanapsis is differentially related to lung function trajectories with distinct structural and functional patterns in COPD and variable risk for adverse outcomes

Ross, James C.; San José Estépar, Raul; Ash, Sam; Pistenmaa, Carrie; Han, MeiLan; Bhatt, Surya P.; Bodduluri, Sandeep; Sparrow, David; Charbonnier, Jean-Paul; Washko, George R.; Diaz, Alejandro A.

doi:10.1016/j.eclinm.2023.102408

Cited by 3 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to updated guidelines, this condition signifies a convergence of dysanaptic growth and mild obstruction. Nonetheless, some researchers point out the resemblance between dysanapsis and pre-obstruction, suggesting potential interchangeability [60,61].…”

Section: Dysanaptic Patternmentioning

confidence: 99%

Pulmonary Function Tests: Easy Interpretation in Three Steps

Ora,

Giorgino,

Bettin

et al. 2024

JCM

View full text Add to dashboard Cite

Pulmonary function tests (PFTs) are pivotal in diagnosing and managing a broad spectrum of respiratory disorders. These tests provide critical insights into lung health, guiding diagnoses, assessing disease severity, and shaping patient management strategies. This review addresses the complexities and nuances inherent in interpreting PFT data, particularly in light of recent updates from the European Respiratory Society (ERS) and American Thoracic Society (ATS). These updates have refined interpretive strategies, moving away from definitive diagnostic uses of spirometry to a more probabilistic approach that better accounts for individual variability through the use of Z-scores and lower limits of normal (LLNs). Significantly, this narrative review delves into the philosophical shift in spirometry interpretation, highlighting the transition from direct clinical diagnostics to a more nuanced evaluation geared towards determining the likelihood of disease. It critiques the reliance on fixed ratios and emphasizes the need for reference values that consider demographic variables such as age, sex, height, and ethnicity, in line with the latest Global Lung Function Initiative (GLI) equations. Despite these advances, challenges remain in ensuring uniformity across different predictive models and reference equations, which can affect the accuracy and consistency of interpretations. This paper proposes a streamlined three-step framework for interpreting PFTs, aiming to unify and simplify the process to enhance clarity and reliability across various medical specialties. This approach not only aids in accurate patient assessments but also mitigates the potential for misdiagnosis and ensures more effective patient management. By synthesizing contemporary guidelines and integrating robust physiological principles, this review fosters a standardized yet flexible approach to PFT interpretation that is both scientifically sound and practically feasible.

show abstract

Section: Dysanaptic Patternmentioning

confidence: 99%

Pulmonary Function Tests: Easy Interpretation in Three Steps

Ora,

Giorgino,

Bettin

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

Advances in COPD imaging using CT and MRI: linkage with lung physiology and clinical outcomes

Elbehairy,

Marshall,

Naish

et al. 2024

Eur Respir J

View full text Add to dashboard Cite

Recent years have witnessed major advances in lung imaging in patients with chronic obstructive pulmonary disease (COPD). These include significant refinements in images obtained by computed tomography (CT) scans together with the introduction of new techniques and software that aim for obtaining the best image while using the lowest possible radiation dose. Magnetic resonance imaging (MRI) has also emerged as a useful radiation-free tool in assessing structural and more importantly functional derangements in patients with well-established COPD and smokers without COPD, even before the existence of overt changes in resting physiological lung function tests.Together, CT and MRI now allow objective quantification and assessment of structural changes within the airways, lung parenchyma, and pulmonary vessels. Furthermore, CT and MRI can now provide objective assessments of regional lung ventilation and perfusion and multi-nuclear MRI provides further insight into gas exchange; this can help in structured decisions regarding treatment plans. These advances in chest imaging techniques have brought new insights into understanding disease pathophysiology and characterizing different disease phenotypes. The present review discusses, in detail, the advances in lung imaging in patients with COPD and how structural and functional imaging are linked with common resting physiological tests and important clinical outcomes.

show abstract

Patterns of Development of Clinical and Functional Disorders of the Bronchopulmonary System in the Post-Accident Period in Persons Exposed to Ionizing Radiation

Shvaiko,

Bazyka,

Shilenko

et al. 2024

Probl Radiac Med Radiobiol

View full text Add to dashboard Cite

The objective of the study was to establish the relationship between functional status of bronchopulmonary system and obstructive sleep apnea in clean-up workers of Chornobyl NPP accident in a remote post-accident period. Materials and methods. A retrospective analysis of 824 cases of COPD in male patients who underwent inpatient treatment in the radiation pulmonology department from 2014 to 2024 was conducted. The observation groups included 579 (70.3%) of urban residents (main group) and 245 (29.7%) of COPD patients (nosological control) who were irradiated within the natural background. For prospective observation, 100 COPD patients from urban residents and 30 COPD patients from the NC group were selected. A complex of clinical and functional tests was provided. Results. In clean-up workers of Chornobyl NPP accident with COPD The regularities of damage to the bronchopulmonary system under the influence of ionizing radiation should be considered a change in the minimal clinical symptoms of the early period, the rapid development of fibrotic changes in the lungs and bronchial mucosa, which is accompanied by a deepening of violations of functional pulmonary tests, structural and morphological changes according to the results of radiological research methods. Conclusions The analysis of various patterns and phenotypes of COPD requires further study in order to improve early diagnosis and treatment of the disease, in particular in people who have suffered as a result of exposure to ionizing radiation. Key words: clean-up workers of Chornobyl NPP accident, pulmonary function tests.

show abstract

Dysanapsis is differentially related to lung function trajectories with distinct structural and functional patterns in COPD and variable risk for adverse outcomes

Cited by 3 publications

References 24 publications

Pulmonary Function Tests: Easy Interpretation in Three Steps

Pulmonary Function Tests: Easy Interpretation in Three Steps

Advances in COPD imaging using CT and MRI: linkage with lung physiology and clinical outcomes

Patterns of Development of Clinical and Functional Disorders of the Bronchopulmonary System in the Post-Accident Period in Persons Exposed to Ionizing Radiation

Contact Info

Product

Resources

About