Dysanaptic growth of lung and airway in children with post‐infectious bronchiolitis obliterans

Mosquera, Ricardo A.; Hashmi, S. Shahrukh; Pacheco, Susan E.; Reverdin, A.; Chevallier, Justyna; Colasurdo, Giuseppe N.

doi:10.1111/crj.12037

Cited by 24 publications

(25 citation statements)

References 25 publications

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“…Mosquera R. et al informed that over time, FVC (lung parenchyma) increased and FEV1 (airway) remained stable, suggesting a mismatch in the growth of the airway and lung parenchyma, dysanaptic growth. Afterwards, one larger study was performed, in which 46 patients were followed for an average of 12.5 years, confirming previous findings.…”

Section: Discussionmentioning

confidence: 99%

Post‐infectious bronchiolitis obliterans

Colom

Teper

2018

Pediatric Pulmonology

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Bronchiolitis obliterans is a rare and severe chronic lung disease resulting from a lower respiratory tract lesion. It may occur after a bone marrow or lung transplantation, infectious diseases, or less frequently after inhaling toxic substances or after connective tissue diseases. Pathology, pathogenesis, and molecular biology, as well as the best treatment of bronchiolitis obliterans, remain the subject of ongoing research. This review discusses our current knowledge of different areas of bronchiolitis obliterans associated with infectious lesions. K E Y W O R D S adenovirus, dysinaptic growth, lung development, Mycoplasma, respiratory function tests 212 |

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Section: Discussionmentioning

confidence: 99%

Post‐infectious bronchiolitis obliterans

Colom

Teper

2018

Pediatric Pulmonology

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“…The same process may occur after lobar resection due to compensatory growth of the remaining lung parenchyma. The mismatch in the growth of the airways and pulmonary parenchyma, called dysanaptic growth, has also be shown to be the cause of changes in pulmonary function tests in babies with post infectious lung diseases . The hypothesis that minor abnormalities affect also the macroscopically non‐affected lung is supported by the findings that also patients with extralobar BPS, where only sequestrectomy is performed, present respiratory sequelae.…”

Section: Discussionmentioning

confidence: 99%

Outcome of infants operated on for congenital pulmonary malformations

et al. 2016

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“…A recent follow-up study of lung function in children with PIBO over a period of 35 months (range, 24-82 months) reported increased FVC and stable FEV 1 over time, resulting in a decline in the FEV 1 /FVC ratio, which suggests dysanaptic growth 31) . In addition, the authors reported persistent neutrophilic inflammation several years after the onset of disease in the absence of overt infection, as assessed by microbiological analysis.…”

Section: The Duration Of Inflammation After the Insult In Children Wimentioning

confidence: 99%

“…In addition, it has been suggested that azithromycin, a macrolide antibiotic with anti-inflammatory properties, may be beneficial for the progression of BOS after LT or HSCT, however, the results are controversial 47 48 49 50) . In children with PIBO, azithromycin has been used clinically without supporting evidence 31) .…”

Section: Treatmentmentioning

confidence: 99%

Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation

2015

Korean J Pediatr

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Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images. However, lung function tests using spirometry are not feasible in young children, and most cases of PIBO develop during early childhood. Further studies focused on obtaining serial measurements of lung function in infants and toddlers with a risk of bronchiolitis obliterans (BO) after lower respiratory tract infection are therefore needed. Although an optimal treatment for PIBO has not been established, corticosteroids have been used to target the inflammatory component. Other treatment modalities for BO after lung transplantation or hematopoietic stem cell transplantation have been studied in clinical trials, and the results can be extrapolated for the treatment of PIBO. Lung transplantation remains the final option for children with PIBO who have progressed to end-stage lung disease.

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Dysanaptic growth of lung and airway in children with post‐infectious bronchiolitis obliterans

Cited by 24 publications

References 25 publications

Post‐infectious bronchiolitis obliterans

Post‐infectious bronchiolitis obliterans

Outcome of infants operated on for congenital pulmonary malformations

Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation

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