Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

Cao, Hailong; Liu, Xiang; An, Yingying; Zhou, Guoqiong; Liu, Yanrong; Xu, Mengque; Dong, Wenxiao; Wang, Sinan; Yan, Fang; Jiang, Kui; Wang, Bangmao

doi:10.1038/s41598-017-10835-8

Cited by 196 publications

(164 citation statements)

References 66 publications

Supporting

Mentioning

155

Contrasting

Unclassified

Order By: Relevance

“…Asian Americans have higher rates of type 2 diabetes and pathogenic infections than Caucasians (66), and two metagenomic functions enriched in control versus type 2 diabetes cases appear to be largely conferred by cluster-associated butyrate-producing and motility-inducing Verrucomicrobiaceae and Clostridia taxa reduced in abundance among AGP and HMP Asian-Pacific Islanders (11). Both induction of cell motility and butyrate promotion of mucin integrity can protect against pathogenic colonization and associate with microbial community changes (11, 58, 67). Levels of cell motility and butyrate are key factors suspected to underlie a range of health disparities including inflammatory bowel disease, arthritis, and type 2 diabetes (11, 68–70).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Diversity across Ethnicities in the United States

Brooks

Priya

Blekhman

et al. 2018

Preprint

View full text Add to dashboard Cite

32Composed of hundreds of microbial species, the composition of the human gut 33 microbiota can vary with chronic diseases underlying health disparities that 34 disproportionally affect ethnic minorities. However, the influence of ethnicity on the gut 35 microbiota remains largely unexplored and lacks reproducible generalizations across 36 studies. By distilling associations between ethnicity and differences in two United States 37 based 16S gut microbiota datasets including 1,673 individuals, we report 12 microbial 38 genera and families that reproducibly vary by ethnicity. Interestingly, a majority of these 39 microbial taxa, including the most heritable bacterial family, Christensenellaceae, overlap 40 with genetically-associated taxa and form co-occurring clusters linked by similar 41 fermentative and methanogenic metabolic processes. These results demonstrate recurrent 42 associations between specific taxa in the gut microbiota and ethnicity, providing hypotheses 43 for examining specific members of the gut microbiota as mediators of health disparities. 44Here, we comprehensively examine connections between self-declared ethnicity and 68 gut microbiota differences across more than a thousand individuals sampled by the 69 American Gut Project (AGP, N=1375) (24) and the Human Microbiome Project (HMP, N=298) 70 (6). Previous studies demonstrated that human genetic diversity in the HMP associates with 71 differences in microbiota composition (25), and genetic population structure within the HMP 72 generally delineates self-declared ethnicity (20). Ethnicity was not found to have a 73 significant association with microbiota composition in a Middle Eastern population, 74 however factors such as lifestyle and environment that influence microbiota variation across 75 participants was homogenous compared to the ethnic, sociocultural, economic, and dietary 76 diversity found within the United States (26). While ethnic diversity is generally 77 underrepresented in current microbiota studies, evidence supporting an ethnic influence on 78 microbiota composition among first generation immigrants has been recently demonstrated 79 in a Dutch population (27). The goal of this examination is to evaluate, for the first time, if 80 there are reproducible differences in gut microbiota across ethnicities within an overlapping 81 United States population, as ethnicity is one of the key defining factors for health disparity 82 incidence in the United States. Lifestyle, dietary, and genetic factors all vary to different 83 degrees across ethnic groups in the United States, and it will require more even sampling of 84 ethnic diversity and stricter phenotyping of study populations to disentangle which factors 85 underlie ethnic microbiota variation in the AGP and HMP. 86 6 Results: 87 Microbiota are subtly demarcated by ethnicity 88We first evaluate gut microbiota distinguishability between AGP ethnicities (Fig 1A, 89 family taxonomic level, Asians-Pacific Islanders (N=88), Caucasians (N=1237), Hispanics 90 (N=37), and African Americ...

show abstract

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Diversity across Ethnicities in the United States

Brooks

Priya

Blekhman

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…However, as the balance can be disrupted by various factors including host genetics, diet, antibiotics and stress, altered microorganisms potentially initiate and perpetuate different disorders. 5 Various studies have shown that microbial alternations, characterized by a marked increase in the numbers of pathogens and a relative decrease in levels of beneficial bacteria, are connected with the development of gastrointestinal and extra-gastrointestinal cancers. [6][7][8][9][10][11][12][13] Altering the gut microbiota is expected as a novel method to deal with diseases associated with intestinal dysbiosis.…”

Section: Introductionmentioning

confidence: 99%

Fecal microbiota transplantation in cancer management: Current status and perspectives

Chen

Jin

et al. 2018

Intl Journal of Cancer

Self Cite

236

161

View full text Add to dashboard Cite

The human gut is home to a large and diverse microbial community, comprising about 1,000 bacterial species. The gut microbiota exists in a symbiotic relationship with its host, playing a decisive role in the host's nutrition, immunity and metabolism. Accumulating studies have revealed the associations between gut dysbiosis or some special bacteria and various cancers. Emerging data suggest that gut microbiota can modulate the effectiveness of cancer therapies, especially immunotherapy. Manipulating the microbial populations with therapeutic intent has become a hot topic of cancer research, and the most dramatic manipulation of gut microbiota refers to fecal microbiota transplantation (FMT) from healthy individuals to patients. FMT has demonstrated remarkable clinical efficacy against Clostridium difficile infection (CDI) and it is highly recommended for the treatment of recurrent or refractory CDI. Lately, interest is growing in the therapeutic potential of FMT for other diseases, including cancers. We briefly reviewed the current researches about gut microbiota and its link to cancer, and then summarized the recent preclinical and clinical evidence to indicate the potential of FMT in cancer management as well as cancer‐treatment associated complications. We also presented the rationale of FMT for cancer management such as reconstruction of intestinal microbiota, amelioration of bile acid metabolism, and modulation of immunotherapy efficacy. This article would help to better understand this new therapeutic approach for cancer patients by targeting gut microbiota.

show abstract

“…Genus level analyses further showed decreased relative abundance of Clostridium , Lactobacillus , Desulfovibrio and Methylobacterium and increased relative abundance of Bacteroides and Akkermansia . The findings suggest a potential role for gut microbiota in the pathogenesis of chronic constipation via increased expression of 5-HT transporter 158 . Interestingly, gut microbiota changes resulting from constipation can further impact GI motility, suggesting a more complex interaction with feedforward regulation rather than a simple cause-effect relationship 53 .…”

Section: Functional Gi Disordersmentioning

confidence: 83%

“…Investigation of the causal relationship between alterations in gut microbial communities and constipation has been described in a recent study 158 reporting upregulation of 5-HT transporter and decreased 5-HT content in the colonic tissue of germ-free mice that received fecal microbiota from constipated patients. 5-HT was negatively correlated with transit time and changes were accompanied by decreased relative abundance of the phylum Firmicutes and increased Bacteroidetes in mice receiving fecal microbiota from constipated patients.…”

Section: Functional Gi Disordersmentioning

confidence: 99%

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Shin

Preidis

Shulman

et al. 2019

Clinical Gastroenterology and Hepatology

133

View full text Add to dashboard Cite

The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota-host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain-gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.

show abstract

Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

Cited by 196 publications

References 66 publications

Gut Microbiota Diversity across Ethnicities in the United States

Gut Microbiota Diversity across Ethnicities in the United States

Fecal microbiota transplantation in cancer management: Current status and perspectives

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Contact Info

Product

Resources

About