Dysbiosis in salivary bacterial diversity of postpartum females and its association with oral health problems and APOs

Bibi, Khadija; Badshah, Lal; Siddiqa, Ayesha; Rehman, Bushra; Anjum, Samiaa; Saeed, Anum; Hussain, Shahzad; Faryal, Rani

doi:10.1016/j.crmicr.2021.100032

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…S. saprophyticus is a primary cause of community-acquired urinary tract infections mainly in sexually active women [ 32 ]. A study by Khadija et al (2021) reported the presence of S. saprophyticus in the oral cavity of 11.98% of women postpartum, although the clinical relevance in the oral cavity is still unclear [ 33 ]. The role of this bacteria in the oral ecosystem of the child is yet to be clarified as well.…”

Section: Discussionmentioning

confidence: 99%

Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

et al. 2023

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In early life, maternal factors are of the utmost relevance for oral microbiome acquisition and maturation. Therefore, our study explored the impact of maternal factors, such as saliva and breastmilk colonization, cardiovascular risk factors (CRF), type of delivery, oral health, and caregiving habits on the prevalence of potential pathogenic and opportunistic oral bacteria in early life. A total of 26 healthy mothers, 23 mothers with CRF, and their 50 children were included and samples (child’s oral swabs, mother’s saliva, and breastmilk) were collected 4 to 12 weeks after delivery and inoculated in selective and differential media for detection of non-fastidious Gram-negative and Gram-positive bacteria to isolate potential pathogenic and opportunistic bacteria identified by MALDI-TOF MS (414 isolates). Within mother–child dyads, the same species were identified in 86% of the pairs and potential pathogenic microorganisms from the Staphylococcaceae and Enterobacteriaceae families were found to be statistically significantly concordant between mother–child samples, particularly in the healthy group. Staphylococcus saprophyticus and Stenotrophomonas maltophilia oral colonization in mother–child pairs were associated with the presence of CRF. Breastfeeding was related to the early life oral colonization of Staphylococcus epidermidis in children from healthy mothers and C-section was associated with higher diversity of pathogens, independent of cardiovascular status (p = 0.05). This study reveals the presence of potential oral opportunistic and pathogenic bacteria in early life and highlights the importance of maternal factors in its acquisition.

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Section: Discussionmentioning

confidence: 99%

Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

et al. 2023

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“…However, it has been previously reported that the Shannon index is different in the depressed group than in healthy adults, although there was no significant difference in the mean values of the diversity (Wingfield et al, 2021). Several reports concluded that there was no significant difference in the alpha diversity of oral microbiome between pregnant and nonpregnant groups (Sparvoli et al, 2020), between patients with anxiety and depression and control subjects (Simpson et al, 2020), or between postpartum and nonpregnant females (Khadija et al, 2021). Further analysis is required to clarify whether changes in the alpha diversity of oral microbiome depend on the oral environment, disease, and/or mouth conditions.…”

Section: Discussionmentioning

confidence: 94%

Oral microbiome changes associated with the menstrual cycle in healthy young adult females

Yamazaki

Ogura

Minami

et al. 2023

Front. Cell. Infect. Microbiol.

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The relationship between the menstrual cycle and the oral microbiome has not been clarified. The purpose of this study was to assess potential changes in the oral microbiome of healthy young adults using 16S rRNA-based sequencing. Eleven females (aged 23–36 years) with stable menstrual cycles and without any oral problems were recruited. Saliva samples were collected before brushing every morning during the menstrual period. Based on basal body temperatures, menstrual cycles were divided into four phases, namely the menstrual, follicular, early luteal, and late luteal phases. Our results showed that the follicular phase had a significantly higher abundance ratio of the Streptococcus genus than the early and late luteal phases, whereas the abundance ratios of the Prevotella 7 and Prevotella 6 genera were significantly lower in the follicular phase than those in the early and late luteal phases and that in the early luteal phase, respectively. Alpha diversity by the Simpson index was significantly lower in the follicular phase than that in the early luteal phase, and beta diversity showed significant differences among the four phases. Using the relative abundance data and copy numbers of the 16S rRNA genes in the samples, the bacterial amounts in the four phases were compared, and we observed that the follicular phase had significantly lower amounts of the Prevotella 7 and Prevotella 6 genera than the menstrual and early luteal phase, respectively. These results indicate reciprocal changes with the Streptococcus genus and Prevotella genera, particularly in the follicular phase. In the present study, we showed that the oral microbiome profiles are affected by the menstrual cycles of healthy young adult females.

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“…In the last trimester of pregnancy, periodontal disease and dental caries-related oral microbiota predominate. Among women in the immediate postpartum period, especially those with poor oral hygiene, multidrug-resistant colonies are upregulated and a decrease in oral bacterial diversity is observed compared with that in nonpregnant women, suggesting the importance of oral management from pregnancy to postpartum ( 117 ). The examination of the gut microbiota of patients with IBD has revealed many oral microbiota, suggesting a direct recent migration.…”

Section: Association Between Oral Microbiota and Systemic Diseasesmentioning

confidence: 99%

Impact of oral microbiota on pathophysiology of GVHD

2023

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Allogeneic transplantation of hematopoietic cells is the only curative therapy for several hematopoietic disease in which patients receive cytotoxic conditioning regimens followed by infusion of hematopoietic stem cells. Although the outcomes have improved over the past decades, graft-versus-host-disease (GVHD), the most common life-threatening complication, remains a major cause of non-relapse morbidity and mortality. Pathophysiology of acute GVHD characterized by host antigen-presenting cells after tissue damage and donor T-cells is well studied, and additionally the importance of recipient microbiota in the intestine is elucidated in the GVHD setting. Oral microbiota is the second most abundant bacterial flora in the body after the intestinal tract, and it is related to chronic inflammation and carcinogenesis. Recently, composition of the oral microbiome in GVHD related to transplantation has been characterized and several common patterns, dysbiosis and enrichment of the specific bacterial groups, have been reported. This review focuses on the role of the oral microbiota in the context of GVHD.

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Dysbiosis in salivary bacterial diversity of postpartum females and its association with oral health problems and APOs

Cited by 4 publications

References 38 publications

Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

Oral microbiome changes associated with the menstrual cycle in healthy young adult females

Impact of oral microbiota on pathophysiology of GVHD

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