Dysbiosis of Oral Microbiota Associated with Palmoplantar Pustulosis

Kageyama, Yasunari; Shimokawa, Yutaka; Kawauchi, Kimihiko; Morimoto, Masafumi; Aida, Koichi; Akiyama, Tetsu; Nakamura, Tsutomu

doi:10.1159/000511622

Cited by 9 publications

(7 citation statements)

References 50 publications

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“…Second, the induction of pustule formation requires neutrophil recruitment into an intraepidermal vesicle, which was not reproduced in our mouse model. The release of IL-8 and IL-36, key cytokines that mediate neutrophil recruitment, in human tonsil epithelial cells and primary NHEKs exposed to cigarette smoke was also shown to contribute to the pathogenesis of PPP 34 , as was dysbiosis of the oral microbiota 35 – 37 . In a previous study, our group detected a microbiome in sterile pustules of PPP 38 .…”

Section: Discussionmentioning

confidence: 99%

A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis

Yatsuzuka,

Kawakami,

Niko

et al. 2024

Sci Rep

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Sweat is an essential protection system for the body, but its failure can result in pathologic conditions, including several skin diseases, such as palmoplantar pustulosis (PPP). As reduced intraepidermal E-cadherin expression in skin lesions was confirmed in PPP skin lesions, a role for interleukin (IL)-1-rich sweat in PPP has been proposed, and IL-1 has been implicated in the altered E-cadherin expression observed in both cultured keratinocytes and mice epidermis. For further investigation, live imaging of sweat perspiration on a mouse toe-pad under two-photon excitation microscopy was performed using a novel fluorescent dye cocktail (which we named JSAC). Finally, intraepidermal vesicle formation which is the main cause of PPP pathogenesis was successfully induced using our "LASER-snipe" technique with JSAC. "LASER-snipe" is a type of laser ablation technique that uses two-photon absorption of fluorescent material to destroy a few acrosyringium cells at a pinpoint location in three-dimensional space of living tissue to cause eccrine sweat leakage. These observatory techniques and this mouse model may be useful not only in live imaging for physiological phenomena in vivo such as PPP pathomechanism investigation, but also for the field of functional physiological morphology.

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Section: Discussionmentioning

confidence: 99%

A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis

Yatsuzuka,

Kawakami,

Niko

et al. 2024

Sci Rep

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“…However, whether reactions to dental metal are causal of PPP remains controversial (Masui et al, 2019). It is hypothesized that odontogenic diseases lead to increased immune activation, which contributes to PPP (Kikuchi and Yamamoto, 2013), and that changes in oral microbiota may be relevant to PPP (Kageyama et al, 2020).…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

SnapshotDx Quiz: May 2021

Raval

Dube

Musiek

2021

Journal of Investigative Dermatology

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“…All studies [18][19][20][21][22] were reported the PASI scores, because the heterogeneity among the studies was not significant (p = 0.001, I 2 = 78%), we chose a random-effect model. The results showed that PASI scores were significantly lower in the probiotic supplement group (SMD = −1.40, 95% Cl = −2.63 to −0.17, p < 0.00001) (Figure 3).…”

Section: Psoriasis Area and Severity Indexmentioning

confidence: 99%

Efficacy of probiotic supplementation in the treatment of psoriasis—A systematic review and meta‐analysis

Wei,

Liao,

Yang

et al. 2024

J of Cosmetic Dermatology

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ObjectiveMany studies have emphasized the possible role of probiotics in psoriasis, probiotic supplementation might be helpful to treat psoriasis. This study systematically evaluated the efficacy of probiotic supplementation for the treatment of psoriasis.MethodsWe searched some databases with keywords until November 10, 2023, including PubMed, Cochrane Library, Embase, and Web of Science. These keywords included probiotics, psoriasis RCT, and so on. After rigorous literature screening by two authors, five studies were identified. Eventually, the required data were independently extracted by another author.ResultsA total of five studies with 286 patients were included. The pooled results showed that the efficacy of probiotic supplementation was superior to placebo in the treatment of psoriasis. The Psoriasis Area and Severity Index (SMD = −1.40, 95% Cl = −2.63 to −0.17, p < 0.00001) and Dermatology Life Quality Index (SMD = −0.92, 95% Cl = −1.86 to 0.01, p < 0.00001). Score decreased after probiotic supplementation.ConclusionsThe meta‐analysis showed that probiotic supplementation could be a new treatment option for psoriasis.

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Dysbiosis of Oral Microbiota Associated with Palmoplantar Pustulosis

Cited by 9 publications

References 50 publications

A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis

A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis

SnapshotDx Quiz: May 2021

Efficacy of probiotic supplementation in the treatment of psoriasis—A systematic review and meta‐analysis

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