Dysbiotic gut microbiota in patients with inflammatory rosacea: another clue towards the existence of a brain–gut–skin axis

Moreno‐Arrones, Óscar M.; ­Ortega‐Quijano, ­Daniel; Brocal, Vicente Pérez; Jiménez, Noé; Heras, Elena de las; Moya, Andrés; Pérez‐García, B.

doi:10.1111/bjd.20411

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…On the other hand, studies characterizing the gut microbiota of rosacea patients based on NGS are also scarce. In this regard, significant differences have been consistently identified at genera level between rosacea patients and rosacea-free individuals ( Nam et al, 2018 ; Chen et al, 2021 ; Moreno-Arrones et al, 2021 ). All these findings at skin and gut microbiota level reinforce the role of the skin-gut axis in the pathophysiology of rosacea.…”

Section: Discussionmentioning

confidence: 97%

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Rosacea, microbiome and probiotics: the gut-skin axis

Sánchez-Pellicer,

Eguren-Michelena,

García-Gavín

et al. 2024

Front. Microbiol.

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Rosacea is an inflammatory skin disease involving diverse symptoms with a variable clinical progress which can severely impact the patient’s quality of life as well as their mental health. The pathophysiological model of rosacea involves an unbalanced immune system predisposed to excessive inflammation, in addition to vascular and nervous alterations, being certain cutaneous microorganisms’ triggers of the symptoms onset. The gut-skin axis explains a bidirectional interaction between skin and gut microbiota in some inflammatory skin diseases such as atopic dermatitis, psoriasis, or rosacea. The introduction and consolidation of the next-generation sequencing in recent years has provided unprecedented information about the microbiome. However, the characterization of the gut and skin microbiota and the impact of the gut-skin axis in patients with rosacea has been little explored, in contrast to other inflammatory skin diseases such as atopic dermatitis or psoriasis. Furthermore, the clinical evolution of patients with rosacea is not always adequate and it is common for them to present a sustained symptomatology with frequent flare-ups. In this context, probiotic supplementation could improve the clinical evolution of these patients as happens in other pathologies. Through this review we aim to establish and compile the basics and directions of current knowledge to understand the mechanisms by which the microbiome influences the pathogenesis of rosacea, and how modulation of the skin and gut microbiota could benefit these patients.

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Section: Discussionmentioning

confidence: 97%

“…The most recently published study is that of Moreno-Arrones et al evaluating the gut microbiota of 15 PPR patients (mean age 36 years, 80% females) and 15 controls (mean age 39 years, 33% females) ( Moreno-Arrones et al, 2021 ). The CHAO1 richness index was increased in PPR patients.…”

Section: Analysis Of the Gut Microbiota In Rosacea Patientsmentioning

confidence: 99%

Rosacea, microbiome and probiotics: the gut-skin axis

Sánchez-Pellicer,

Eguren-Michelena,

García-Gavín

et al. 2024

Front. Microbiol.

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“…Our study showed the protective effects of the genus Prevotella7 against melanoma and rosacea and the likely protective effects of the genus Prevotella9 against psoriasis. An analysis of the gut microbiota of 15 rosacea patients and 15 healthy individuals showed that Prevotella was more enriched in the intestines of healthy individuals than in patients ( Moreno-Arrones et al., 2021 ). Given that Prevotella has been found to be more scarce in the gut of Parkinson’s disease patients and that rosacea and Parkinson’s disease are epidemiologically linked, further exploration of the role of this bacterium in the brain–gut–skin axis is warranted ( Egeberg et al., 2016 ; Gerhardt and Mohajeri, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and pan-dermatological diseases: a bidirectional Mendelian randomization research

Wang,

Yao,

Lin

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundGut microbiota has been associated with dermatological problems in earlier observational studies. However, it is unclear whether gut microbiota has a causal function in dermatological diseases.MethodsThirteen dermatological diseases were the subject of bidirectional Mendelian randomization (MR) research aimed at identifying potential causal links between gut microbiota and these diseases. Summary statistics for the Genome-Wide Association Study (GWAS) of gut microbiota and dermatological diseases were obtained from public datasets. With the goal of evaluating the causal estimates, five acknowledged MR approaches were utilized along with multiple testing corrections, with inverse variance weighted (IVW) regression serving as the main methodology. Regarding the taxa that were causally linked with dermatological diseases in the forward MR analysis, reverse MR was performed. A series of sensitivity analyses were conducted to test the robustness of the causal estimates.ResultsThe combined results of the five MR methods and sensitivity analysis showed 94 suggestive and five significant causal relationships. In particular, the genus Eubacterium_fissicatena_group increased the risk of developing psoriasis vulgaris (odds ratio [OR] = 1.32, pFDR = 4.36 × 10−3), family Bacteroidaceae (OR = 2.25, pFDR = 4.39 × 10−3), genus Allisonella (OR = 1.42, pFDR = 1.29 × 10−2), and genus Bacteroides (OR = 2.25, pFDR = 1.29 × 10−2) increased the risk of developing acne; and the genus Intestinibacter increased the risk of urticaria (OR = 1.30, pFDR = 9.13 × 10−3). A reverse MR study revealed insufficient evidence for a significant causal relationship. In addition, there was no discernible horizontal pleiotropy or heterogeneity.ConclusionThis study provides novel insights into the causality of gut microbiota in dermatological diseases and therapeutic or preventive paradigms for cutaneous conditions.

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“…This was potentially mediated by modulation of the gastrointestinal (GI) microbiota. Altered GI microbiota, a pivotal element of gut-skin axis, has been observed by emerging studies in rosacea and might be responsible for increased risks of GI comorbidities in rosacea ( 37 , 38 ). Multiple nutrients from MD, including polyphenols, polyunsaturated fatty acids (PUFAs) and fiber, contribute to modulations of the gut microbiota both in the aspects of diversity and inflammatory response ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of adherence to Mediterranean-like diet pattern with incident rosacea: A prospective cohort study of government employees in China

Chen

Yang²,

Fan³

et al. 2023

Front. Nutr.

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BackgroundDespite of growing evidence on gastrointestinal comorbidities of rosacea, there was a lack of literatures regarding the role of diet on rosacea.ObjectivesTo investigate the relationship between adherence to a Mediterranean-like diet pattern and the risk of incident rosacea.MethodsThis was a prospective cohort study of government employees aged >20 years conducted between January 2018 and December 2021 from five cities of Hunan province of China. At baseline, participants completed a food frequency questionnaire and participated in a skin examination. Presence of rosacea was determined by certified dermatologists. Subsequent skin examinations during follow-up were performed every one-year interval since the entry of the study. The Mediterranean diet score (MDS) was generated based on seven food groups (whole grains, red meats, fish, raw vegetables, legumes, fruits and nuts). Binary logistic regression models adjusted for potential confounders were used to estimate risks for incident rosacea.ResultsOf the 3,773 participants who completed at least two consecutive skin examinations, 3,496 were eligible for primary analyses. With a total follow-up of 8,668 person-years, we identified 83 incident rosacea cases. After full adjustments for covariates, the MDS was associated a decreased risk of incident rosacea (aOR: 0.84, 95% CI: 0.72, 0.99; Ptrend = 0.037 for 1-point increment of MDS). In subgroup analyses by body mass index (BMI), this inverse association was consistently observed in the lowest and medium tertiles of BMI (<24.5 kg/m2), but not in the highest tertile of BMI (≥24.5 kg/m2), with a significant interaction effect (P < 0.001).ConclusionsOur results suggested that adherence to a Mediterranean-like diet pattern might reduce the risk of incident rosacea among non-overweight individuals.

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Dysbiotic gut microbiota in patients with inflammatory rosacea: another clue towards the existence of a brain–gut–skin axis

Cited by 10 publications

References 8 publications

Rosacea, microbiome and probiotics: the gut-skin axis

Rosacea, microbiome and probiotics: the gut-skin axis

Association between gut microbiota and pan-dermatological diseases: a bidirectional Mendelian randomization research

Associations of adherence to Mediterranean-like diet pattern with incident rosacea: A prospective cohort study of government employees in China

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