Dyschromatosis symmetrica hereditaria: A retrospective case series and literature review

Speckled acral hypopigmentation in an adolescent

“…DSH, also known as acropigmentation of Dohi, is an inherited disorder with a mutation in the ADAR1 gene. It presents with progressive hyper‐ and hypopigmented macules in a reticulate pattern on the dorsal hands and feet beginning in infancy . Patients may have associated neurologic sequelae and hair and dental abnormalities .…”

Dyschromatosis symmetrica hereditaria: Report of a sporadic case in a Nigerian child

“…It phenotypically presents as pinpoint or peasized symmetrical mottled hypo-and hyperpigmented macules, typically in an acral distribution. There may be associated freckle-like macules on the face, extension of acral lesions proximally and lesions on the chest 3,4 . Onset of DSH is usually in infancy and childhood, with progression and eventual stabilization prior to adolescence and this lasts for life, however, Gaiewski 9 reported a late onset presentation, with acral lesions beginning at the age of 26 years.…”

“…Dyschromatosissymmetricahereditaria (DSH) (aka. Reticulate acropigmentation of Dohi) is a rare genodermatoses which was first described in Japan 1 and has been more widely reported among Asian populations [2][3][4] . There have also been few reports among Caucasians and in some Middle Eastern countries [5][6][7] .…”

A novel nonsense mutation of ADAR1 gene in a Chinese patient with dyschromatosis symmetrica hereditaria

“…A novel nonsense mutation of ADAR1 gene in a Chinese patient with dyschromatosis symmetrica hereditaria Editor Dyschromatosis symmetrica hereditaria (DSH, MIM 127400) is an autosomal dominant pigmentary disorder characterized by the presence of hyperpigmented and hypopigmented macules mostly on the dorsal of the extremities, which first appear in infancy or early adolescence, and last for life. 1 Genetic studies have certified that the mutations in the ADAR1 gene are responsible for the disorder. So far, more than 100 mutations in the ADAR1 gene have been reported that were associated with the disorder.…”

“…Localized guttate psoriasis in a patient with erythema migrans Editor More than 140 years ago, Heinrich K€ obner described an isomorphic phenomenon in a patient with psoriasis. 1 This so-called K€ obner phenomenon is one of the most well-known entities in dermatology and has been well documented in psoriasis, vitiligo and lichen planus as well as in variety of other inflammatory skin diseases. 2 A 53-year-old woman visited her family doctor with a red macule on her right buttock that had been present for some weeks.…”