Dysconnectivity of the inferior frontal gyrus: Implications for an impaired self-other distinction in patients with schizophrenia

Backasch, Bianca; Sommer, Jens; Klöhn-Saghatolislam, Farahnaz; Müller, Matthias J.; Kircher, Tilo; Leube, Dirk T.

doi:10.1016/j.pscychresns.2014.05.007

Cited by 31 publications

(15 citation statements)

References 72 publications

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“…Many studies have investigated brain regions involved in temporal errors between actions and feedback using delayed visual feedback, similar to the current study (133–144). Most of these studies have identified parietal areas that were active during such discrepancies, in particular the IPL (angular gyrus).…”

Section: Discussionmentioning

confidence: 67%

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

et al. 2018

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Limb apraxia is a higher brain dysfunction that typically occurs after left hemispheric stroke and its cause cannot be explained by sensory disturbance or motor paralysis. The comparison of motor signals and visual feedback to generate errors, i.e., visuo-motor integration, is important in motor control and motor learning, which may be impaired in apraxia. However, in apraxia after stroke, it is unknown whether there is a specific deficit in visuo-motor temporal integration compared to visuo-tactile and visuo-proprioceptive temporal integration. We examined the precision of visuo-motor temporal integration and sensory-sensory (visuo-tactile and visuo-proprioception) temporal integration in apraxia after stroke by using a delayed visual feedback detection task with three different conditions (tactile, passive movement, and active movement). The delay detection threshold and the probability curve for delay detection obtained in this task were quantitative indicators of the respective temporal integration functions. In addition, we performed subtraction and voxel-based lesion-symptom mapping to identify the brain lesions responsible for apraxia and deficits in visuo-motor temporal integration. The behavioral experiments showed that the delay detection threshold was extended and that the probability curve for delay detection was less steep in apraxic patients compared to controls (pseudo-apraxic patients and unaffected patients), only for the active movement condition, and not for the tactile and passive movement conditions. Furthermore, the severity of apraxia was significantly correlated with the delay detection threshold and the steepness of the probability curve in the active movement condition. These results indicated that multisensory (i.e., visual, tactile, and proprioception) feedback was normally temporally integrated, but motor prediction and visual feedback were not correctly temporally integrated in apraxic patients. That is, apraxic patients had difficulties with visuo-motor temporal integration. Lesion analyses revealed that both apraxia and the distortion of visuo-motor temporal integration were associated with lesions in the fronto-parietal motor network, including the left inferior parietal lobule and left inferior frontal gyrus. We suppose that damage to the left inferior fronto-parietal network could cause deficits in motor prediction for visuo-motor temporal integration, but not for sensory-sensory (visuo-tactile and visuo-proprioception) temporal integration, leading to the distortion of visuo-motor temporal integration in patients with apraxia.

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Section: Discussionmentioning

confidence: 67%

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

et al. 2018

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“…Finally, the pars opercularis has been shown to be involved in a variety of tasks requiring working memory, such as associative learning, recall of topographic routes, and verbal memory (Liakakis et al ), processes that can be disrupted under disease states. For example, pathologic activation patterns of the right pars opercularis have been implicated in the impaired agency attributions found in schizophrenia, reflecting a role for BA 44 in the disentanglement of information regarding neural representations of self and others (Backasch et al ). Additionally, patients with behavioral‐variant frontotemporal dementia have demonstrated deficits in categorizing the type of emotion displayed by the gait patterns of 3D‐generated avatars (Jastorff et al ).…”

Section: Discussionmentioning

confidence: 99%

“…For example, the IFG is known to play roles in language production, fine motor control, and emotional awareness (Liakakis et al ; Hagoort ). Lesion and human neuroimaging studies have demonstrated that the functional processes attributed to the IFG may be disrupted as a result of neoplastic or neuropsychiatric disease (Alexander et al ; Alexander et al ; Jeong et al ; Backasch et al ). The IFG is also important in processes requiring the evaluation and report of semantic information (Hagoort ).…”

Section: Introductionmentioning

confidence: 99%

Anatomy and white matter connections of the inferior frontal gyrus

et al. 2019

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The inferior frontal gyrus (IFG) is involved in the evaluation of linguistic, interoceptive, and emotional information. A detailed understanding of its subcortical white matter anatomy could improve postoperative morbidity related to surgery in and around this gyrus. Through GQI-based fiber tracking validated by gross anatomical dissection as ground truth, we characterized the fiber tracts of the IFG based on relationships to other well-known neuroanatomic structures. Diffusion imaging from the Human Connectome Project for 10 healthy adult controls was used for fiber tracking analysis. We evaluated the IFG as a whole based on its connectivity with other regions. All tracts were mapped in both hemispheres, and a lateralization index was calculated based on resultant tract volumes. Ten cadaveric dissections were then performed using a modified Klingler technique to demonstrate the location of major tracts. We identified four major connections of the IFG: a white matter bundle corresponding the frontal aslant tract connecting to the superior frontal gyrus; the superior longitudinal fasciculus connecting to the inferior parietal lobule, lateral occipital area, posterior temporal areas, and the temporal pole; the inferior fronto-occipital fasciculus connecting to the cuneus and lingual gyrus; and the uncinate fasciculus connecting to the temporal pole. A callosal fiber bundle connecting the inferior frontal gyri bilaterally was also identified. The IFG is an important region implicated in a variety of tasks including language processing, speech production, motor control, interoceptive awareness, and semantic processing. Postsurgical outcomes related to this region may be better understood in the context of the fiber-bundle anatomy highlighted in this study. Clin. Anat. 32:546-556, 2019.

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“…reduced functional connectivity of ventral circuit PFC regions in schizophrenia (Backasch et al, 2014;Diaconescu et al, 2011;He et al, 2013;Lynall et al, 2010;Tomasi and Volkow, 2014). Although these discrepant findings may be attributable to factors including clinical heterogeneity, a more complete understanding of schizophrenia-related abnormalities in these networks can be assisted by examining reported effects in the context of a more comprehensive characterization of the individuals involved (Insel, 2014), and with reference to specific abnormalities in task-related behavior.…”

Section: Discussionmentioning

confidence: 99%

Dysfunctional Striatal Systems in Treatment-Resistant Schizophrenia

White

Wigton

Joyce³

et al. 2015

Neuropsychopharmacol

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The prevalence of treatment-resistant schizophrenia points to a discrete illness subtype, but to date its pathophysiologic characteristics are undetermined. Information transfer from ventral to dorsal striatum depends on both striato-cortico-striatal and striato-nigro-striatal subcircuits, yet although the functional integrity of the former appears to track improvement of positive symptoms of schizophrenia, the latter have received little experimental attention in relation to the illness. Here, in a sample of individuals with schizophrenia stratified by treatment resistance and matched controls, functional pathways involving four foci along the striatal axis were assessed to test the hypothesis that treatment-resistant and non-refractory patients would exhibit contrasting patterns of resting striatal connectivity. Compared with non-refractory patients, treatment-resistant individuals exhibited reduced connectivity between ventral striatum and substantia nigra. Furthermore, disturbance to corticostriatal connectivity was more pervasive in treatment-resistant individuals. The occurrence of a more distributed pattern of abnormality may contribute to the failure of medication to treat symptoms in these individuals. This work strongly supports the notion of pathophysiologic divergence between individuals with schizophrenia classified by treatmentresistance criteria.

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Dysconnectivity of the inferior frontal gyrus: Implications for an impaired self-other distinction in patients with schizophrenia

Cited by 31 publications

References 72 publications

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

Anatomy and white matter connections of the inferior frontal gyrus

Dysfunctional Striatal Systems in Treatment-Resistant Schizophrenia

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