Dyserythropoiesis, Polymyopathy, and Cardiac Disease in Three Related English Springer Spaniels

Holland, C. T.; Canfield, P. J.; Watson, A. D. J.; Allan, G. S.

doi:10.1111/j.1939-1676.1991.tb00942.x

Cited by 45 publications

(48 citation statements)

References 21 publications

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“…Congenital conditions associated with dysplastic features in bone marrow include poodle macrocytosis, 19 congenital dyserythropoiesis, polymyopathy, and cardiac disease in English Springer Spaniels, 20 and inherited selective malabsorption of vitamin B12 in Giant Schnauzers 21 . Other conditions that may result in myelodysplasia include vitamin B12/folic acid deficiency, 22 iron deficiency, 23 and lead toxicity 24 …”

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confidence: 99%

Cytologic Evaluation of Primary and Secondary Myelodysplastic Syndromes in the Dog

Weiss

Aird

2001

Veterinary Clinical Pathol

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Myelodysplastic syndromes are a heterogeneous group of acquired primary and secondary alterations of hematopoietic stem cells that result in cytopenias in blood and cytologic features of dysplasia in blood and/or bone marrow. To better understand the cytologic features that would permit differentiation of primary and secondary forms of myelodysplasia, we reviewed 267 consecutive bone marrow reports from dogs. These reports indicated that 34 dogs (12.7%) had dysgranulopoiesis, dyserythropoiesis, and/or dysthrombopoiesis in >10% of granulopoietic cells, erythroid cells, and/or megakaryocytes, respectively. Thirteen dogs had primary myelodysplastic syndromes, and 21 had secondary myelodysplastic syndromes. Of the 13 dogs with primary myelodysplasia, 4 were subclassified as myelodysplastic syndrome with refractory anemia (MDS-RA), and 9 were subclassified as myelodysplastic syndrome with excess blasts (MDS-EB). Secondary conditions associated with dysplasia in the bone marrow included malignant lymphoma (n = 5), myelofibrosis (n = 3), immune-mediated thrombocytopenia (n = 4), immune-mediated hemolytic anemia (n = 5), multiple myeloma with melphalan administration (n = 1), pyometra with estrogen administration (n = 1), polycythemia vera (n = 1), and thrombopathia (n = 1). MDS-RA was characterized by <5% myeloblasts in bone marrow, normal granulocyte maturation ratio, increased erythroid maturation ratio, and dysplastic changes in >15% of erythroid cells. MSD-EB was characterized by >/=5% myeloblasts in bone marrow, high granulocyte maturation and erythroid maturation ratios, >/=32% dysplastic granulocytes, and the presence of small atypical immature myeloid cells. Secondary myelodysplastic syndromes were characterized by <5% myeloblasts in bone marrow, variable granulocyte maturation and erythroid maturation ratios, and variable dysplastic features. These results indicate that morphology alone cannot be used to distinguish primary and secondary myelodysplastic syndromes in dogs.

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confidence: 99%

Cytologic Evaluation of Primary and Secondary Myelodysplastic Syndromes in the Dog

Weiss

Aird

2001

Veterinary Clinical Pathol

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“…944,945 Dyserythropoiesis, cardiomegaly, and polymyopathy characterized by gross muscle atrophy and histologic evidence of myofiber size variation and poorly defined inclusions have been reported in English springer spaniels. 946 However, the underlying cause of this myopathy has not yet been defined.…”

Section: Mitochondrial and Lipid Storage Myopathiesmentioning

confidence: 99%

Tetraparesis, Hemiparesis, and Ataxia

Lorenz

2011

Handbook of Veterinary Neurology

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“…The primary cardiac conduction defects identified were due mainly to gene mutations involved in the impulse conduction process (e.g., gap junction genes, transcription factors, ionchannel genes) or repolarization process (e.g., ion-channel genes) (Cheng et al 2003;Hyun andFilippich 2006). Biochem Genet (2008) 46:8-17 9 Inherited cardiac conduction defects have also been reported in several dog breeds associated with sudden death syndrome and dilated cardiomyopathy in German shepherds (Moise et al 1994) and boxers (Meurs et al 1999), sick sinus syndrome in miniature schnauzers (Hamlin et al 1972), and atrial standstill in English springer spaniels (Holland et al 1991). However, the genetic etiology associated with these canine conduction diseases is yet to be identified.…”

Section: Introductionmentioning

confidence: 99%

Genetic Screening of the Canine Connexin 40 Gene in Dogs with Inherited Cardiac Conduction Defects

Lee

et al. 2007

Biochem Genet

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Connexin 40 (Cx40) is a gap-junction protein expressed in the heart where it mediates the coordinated electrical activation of the atria and ventricular conduction tissues, facilitates cell-to-cell adhesion, and provides pathways for direct intercellular communication. Recent studies have shown that Cx40 null mice have cardiac conduction abnormalities with a very high incidence of cardiac malformations in heterozygous (18%) and homozygous (33%) animals, indicating that Cx40 plays a vital role in cardiomorphogenesis. Since several inherited cardiac conduction defects have also been found in dogs, we hypothesized that the clinical findings are genetically linked to a tissue-specific mutation or mutations in the canine Cx40 gene. We therefore screened the Cx40 gene in dogs with inherited cardiac conduction defects for mutations. In this study, we have identified three heterozygous base changes (C384G, C402T, C837T) in the dogs screened and determined them to be synonymous mutations. These mutations, however, have recently been found in an unrelated group of normal dogs.

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Dyserythropoiesis, Polymyopathy, and Cardiac Disease in Three Related English Springer Spaniels

Cited by 45 publications

References 21 publications

Cytologic Evaluation of Primary and Secondary Myelodysplastic Syndromes in the Dog

Cytologic Evaluation of Primary and Secondary Myelodysplastic Syndromes in the Dog

Tetraparesis, Hemiparesis, and Ataxia

Genetic Screening of the Canine Connexin 40 Gene in Dogs with Inherited Cardiac Conduction Defects

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