Dysfunction in ABCB1A Has Only a Weak Effect on Susceptibility to Dextran Sulfate Sodium-Induced Colitis in SAM Strains

Abstract

Genetic alterations in the gene for ATP-binding cassette, sub-family B (MDR/ TAP), member 1A (ABCB1A) determine susceptibility to colitis in mice and humans. We investigated the influence of ABCB1A dysfunction on susceptibility to dextran sulfate sodium (DSS)-induced colitis by using Senescence-Accelerated Mouse (SAM) strains with a lossof-function mutation in the Abcb1a gene (SAMR1, SAMP1, and SAMP6). Susceptibility to DSS colitis was different among SAM strains but on the whole was not different from other mouse strains with normal ABCB1A function. Thus, genetic factors other than loss of ABCB1A are more crucial in determining susceptibility to DSS colitis in SAM strains.

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“…However, the difference in body weight results of this study was not likely due to the altered nutrition absorption in the mice. It was previously explained that spontaneous colitis in SAM strains is developed much later than 1 year of age (Zhang et al., ), while in this study mice were sacrificed at 24 weeks of age. Moreover, calculation of the average food intake during the experimental period showed that OC mice consumed 1.20‐fold higher amount of feed than that consumed by YC group, which may explain the higher body weight of mice in the OC group than in the YC group (Figure B).…”

“…During the experimental period, we found that the body weight of YC mice was maintained lower than that of OC mice, as shown in Figure A. Both the YC (SAMR1) and OC (SAMP6) mouse strains are reported to be the animal models of colitis disease, a disease which may cause an alteration of metabolism or a decrease in intestinal nutrient absorption (Ghishan & Kiela, ; Zhang, Fu, Takeda, Higuchi, & Mori, ). However, the difference in body weight results of this study was not likely due to the altered nutrition absorption in the mice.…”