Dysfunction of atrial and B-type natriuretic peptides in congenital univentricular defects

Sun, Lena S.; Domı́nguez, Carmen; Mallavaram, Navin A.; Quaegebeur, Jan M.

doi:10.1016/j.jtcvs.2004.08.025

Cited by 28 publications

(21 citation statements)

References 43 publications

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“…141 Interestingly, patients with univentricular hearts palliated with the Fontan procedure have substantial exercise limitations but BNP levels Ͻ100 pg/mL. 138,139 Some evidence 142 exists that patients with univentricular hearts may have abnormal natriuretic peptide secretion and function. With further experience, measurement of BNP levels may ultimately prove valuable in assessing outcomes in stage C heart failure in pediatric heart disease.…”

Section: Canter Et Almentioning

confidence: 99%

Indications for Heart Transplantation in Pediatric Heart Disease

Canter¹,

Shaddy²,

Bernstein³

et al. 2007

Circulation

261

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Background— Since the initial utilization of heart transplantation as therapy for end-stage pediatric heart disease, improvements have occurred in outcomes with heart transplantation and surgical therapies for congenital heart disease along with the application of medical therapies to pediatric heart failure that have improved outcomes in adults. These events justify a reevaluation of the indications for heart transplantation in congenital heart disease and other causes of pediatric heart failure. Methods and Results— A working group was commissioned to review accumulated experience with pediatric heart transplantation and its use in patients with unrepaired and/or previously repaired or palliated congenital heart disease (children and adults), in patients with pediatric cardiomyopathies, and in pediatric patients with prior heart transplantation. Evidence-based guidelines for the indications for heart transplantation or retransplantation for these conditions were developed. Conclusions— This evaluation has led to the development and refinement of indications for heart transplantation for patients with congenital heart disease and pediatric cardiomyopathies in addition to indications for pediatric heart retransplantation.

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Section: Canter Et Almentioning

confidence: 99%

Indications for Heart Transplantation in Pediatric Heart Disease

Canter¹,

Shaddy²,

Bernstein³

et al. 2007

Circulation

261

View full text Add to dashboard Cite

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“…19 Potential contributing factors include receptor downregulation, alterations in signal transduction, increased phosphodiesterase activity, nonpulsatile flow, and hypothermia. 20,21 In vitro and in vivo studies have found that natriuretic hormones provide protection from myocardial ischemia-reperfusion injury, likely related to modulation of intracellular calcium levels, pH, and angiotensin II effects, which may benefit patients undergoing cardioplegic arrest.…”

Section: Discussionmentioning

confidence: 99%

Impact of Empiric Nesiritide or Milrinone Infusion on Early Postoperative Recovery After Fontan Surgery

Costello

Dunbar‐Masterson

Allan

et al. 2014

Circ: Heart Failure

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Background-We sought to determine whether empirical nesiritide or milrinone would improve the early postoperative course after Fontan surgery. We hypothesized that compared with milrinone or placebo, patients assigned to receive nesiritide would have improved early postoperative outcomes. Methods and Results-In a single-center, randomized, double-blinded, placebo-controlled, multi-arm parallel-group clinical trial, patients undergoing primary Fontan surgery were assigned to receive nesiritide, milrinone, or placebo. A loading dose of study drug was administered on cardiopulmonary bypass followed by a continuous infusion for ≥12 hours and ≤5 days after cardiac intensive care unit admission.

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“…As opposed to ANP and DNP, BNP concentrations increased after cardiopulmonary bypass. Sun and colleagues measured BNP levels before and after surgery in 27 infants and children undergoing biventricular repair and 27 patients undergoing palliation of univentricular congenital heart defects (Sun et al 2005). Plasma BNP levels increased after bypass in patients with biventricular defects, but not in patients with univentricular defects (Sun et al 2005).…”

Section: Early Post-operative Periodmentioning

confidence: 99%

“…Sun and colleagues measured BNP levels before and after surgery in 27 infants and children undergoing biventricular repair and 27 patients undergoing palliation of univentricular congenital heart defects (Sun et al 2005). Plasma BNP levels increased after bypass in patients with biventricular defects, but not in patients with univentricular defects (Sun et al 2005). Costello and colleagues examined BNP levels before and following cardiac surgery in 25 infants and children with congenital heart disease undergoing complete or palliative repair with the use of cardiopulmonary bypass (Costello et al 2004).…”

Section: Early Post-operative Periodmentioning

confidence: 99%