Dysfunctional connectivity patterns in chronic heroin users: An fMRI study

Liu, Jixin; Liang, Jimin; Qin, Wei; Tian, Jie; Yuan, Kai; Bai, Lijun; Zhang, Yi; Wang, Wei; Wang, Yarong; Li, Qiang; Zhao, Liyan; Lü, Lin; Deneen, Karen M. von; Liu, Yijun; Gold, Mark S.

doi:10.1016/j.neulet.2009.05.038

Cited by 178 publications

(128 citation statements)

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“…Furthermore, opiate addicted individuals show a decreased FA value in thalamic radiation due to an increase of radial diffusivity indicating the existence of myelin pathology (Bora et al, 2010). Additionally, topological small-world distortion has been further detected in the thalamus and insula of heroin-dependent individuals (Liu et al, 2009b;Yuan et al, 2010c).The insula serves multiple functions including emotional regulation, integrating information and compiling somatosensory information because it interacts with the thalamus, amygdala, OFC and striatum (Liu et al, 2009b). More precisely, it receives "homeostatic afferent" through the thalamus and sends its outcomes to brain 21 regions such as the striatum, amygdala and OFC (Liu et al, 2009b).…”

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confidence: 94%

“…Additionally, topological small-world distortion has been further detected in the thalamus and insula of heroin-dependent individuals (Liu et al, 2009b;Yuan et al, 2010c).…”

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confidence: 95%

“…The enhanced activation of the hippocampus within the DMN that has been found in heroin-dependent individuals might underlie the increased sensitivity for heroin-related cues because the abnormal augmentation 20 of memory processing seem to mislead the subject's attention and the self-monitoring (Ma et al, 2011). The altered resting-state brain organization which is characterized by an increased degree was evident in theparahippocampal gyrus (Yuan et al, 2010c) as well as the hippocampus (Liu et al, 2009b).Among the memory systems involved in heroin addiction are the putamen and the caudate. These brain regions have been associated with habit learning through which well-learned memories are stored and elicited by the relevant stimuli .…”

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confidence: 98%

“…Hence, its dysfunctions seem to cause drug cue bias, encoding of reward expectancy, decision-making deficits and meditation of heroin-related stimulus salience (Peoples, 2002;Wang et al, 2010). The rostral part of ACC handles inhibition control (Liu et al, 2009b;Yuan et al, 2010a;Zhang et al, 2011). Therefore, its decreased functional connectivity with the OFC, DLPFC and the right middle temporal lobe of heroin-dependent individuals justifies the impairments in inhibition and decision control (Yuan et al, 2010a).…”

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confidence: 99%

“…The caudate and putamen in conjunction with the pallidum, have been further linked to emotional and stress regulation because the dopamine release in the ventral striatum is enhanced under stressful conditions (Pruessner et al, 2004). Disruption of the resting-state striatum equilibrium in heroinaddicts might result in unexpected activation and subsequently in erroneous decisions and relapse (Liu et al, 2009b). Abnormal topological brain organization has been reported in the putamen and caudate (Yuan et al, 2010c).…”

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Resting-state Abnormalities in Heroin-dependent Individuals

Pandria

Kovatsi

Vivas³

et al. 2018

Neuroscience

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractDrug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific regions in the prefrontal, parietal, occipital, and temporal lobes, as well as, some subcortical regions.The brain regions involvedare linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control andseem to form circuitsthat interact with each other. So, along with neuroimaging studies, recent advances in resting-state dynamics might allow further assessments upon the multilayer complexity of addiction. In the current manuscript, we comprehensively reviewand discuss all the existing resting-state neuroimaging findings classified into three overlapping and interconnected groups: functional connectivity alterations, structural deficits and abnormal topological properties. Moreover, behavioral traits of heroin-addicted individuals as well as the limitations of the currently available studies are also reviewed. Finally, in need of a contemporary therapya multimodal therapeutic approach is suggested using classical treatment practices along with current neurotechonologies, such as neurofeedback and goal-oriented video-games Keywords:Heroin addiction, resting-state, functional and structural connectivity, small-world properties, behavioral traits of heroin-dependent individuals. Radial Diffusivity (RD) 5 Drug addiction or substance dependence (Koob and Le Moal, 2005)is defined as a multifaceted neuropsychiatric disorder resulting from complex interactions between neurobiological, environmental, genetic and pharmacological variables (Sutherland et al., 2012).It affects both cognitive as well as emotional processes . Furthermore, the compulsive seeking and taking of the drug despite the negative consequences, (including downward social mobility (Denier et al., 2013b)), constitutes its behavioral phenotype (Volkow ...

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“…Additionally, topological small-world distortion has been further detected in the thalamus and insula of heroin-dependent individuals (Liu et al, 2009b;Yuan et al, 2010c).…”

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confidence: 95%

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confidence: 98%

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confidence: 99%

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confidence: 99%

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